Chemical and Enzymatic Synthesis of Nucleoside Tetraphosphates

Kore, Anilkumar R.; Yang, Bo; Balasubramanian, S.; Conrad, Rick

doi:10.2174/1385272819666140515230833

Cited by 6 publications

(5 citation statements)

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“…[4] We have contributed in this area and developed wide variety of structure directing agents for the synthesis of disordered and ordered nanocrystalline zeolites of different framework structure. [5] It is worthy to note that these efforts were made for the synthesis of Al containing zeolites. Though significant efforts were made to improve the physical property of the zeolites but only a limited effort was made to fine-tune the chemical properties of the zeolites.…”

Section: Introductionmentioning

confidence: 99%

Highly Efficient Silver Nanoparticles Supported Nanocrystalline Zirconosilicate Catalyst for the Epoxidation and Hydration Reactions

2016

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Nanocrystalline zirconosilicate with MFI framework structure was hydrothermally synthesized by the addition of amphiphilic organosilane in the synthesis composition of conventional zirconosilicate. Silver nanoparticles were supported on the surface of nanocrystalline zirconosilicate. Catalyst exhibited exceptional high activity in the epoxidation of olefins. Application of the catalyst was extended in the green catalytic hydration reaction of alkynes and nitriles. Hydration reaction using zirconosilicate does not involve toxic metals or corrosive acidic condition. Bi‐functional nature of the catalyst and optimum polarizability of Zr present in the zeolite matrix are responsible for the high catalytic activity. Recycling and leaching experiments suggest that the catalyst can be reused without significant loss in the activity. Nanocrystalline zirconosilicate offers several attractive features such as sustainable synthetic route, stability, high yields, and recyclability.

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Section: Introductionmentioning

confidence: 99%

Highly Efficient Silver Nanoparticles Supported Nanocrystalline Zirconosilicate Catalyst for the Epoxidation and Hydration Reactions

2016

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“…(1) ( Table S-1). [40,41] To compare the Bronsted acidity of the different ionic liquids the absorbance values recorded for 10 mM solutions are plotted in Figure 1. The order of acidity as 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 obtained from the Figure 1, can be summarized as: IL-1 > IL-6 > IL-7 > IL-8 > IL-2 > IL-4 > IL-5.…”

Section: Resultsmentioning

confidence: 99%

Synergistic Bronsted‐Lewis Acidity Effect on Upgrading Biomass‐Derived Phenolic Compounds: Statistical Optimization of Process Parameters, Kinetic Investigations and DFT Study

et al. 2018

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Biomass‐derived phenolic compounds and small oxygenates obtained from pyrolysis of lignocellulosic biomass needs to be upgraded to obtain the C10‐C13 range fuel precursors. In this context, iso‐propylation of m‐cresol was performed in batch reactors using multifunctional ionic liquids (ILs) as catalysts. Environmentally benign Bronsted‐Lewis acidic ILs were synthesized and characterized using 1H NMR, 13C NMR and Raman spectroscopic data. Relative Bronsted and Lewis acidity of these ILs were compared using UV‐Visible and FTIR spectroscopic data and the effect of acidity on the catalytic activity and product selectivity in alkylation of m‐cresol with iso‐propyl alcohol was investigated. Correlation of acidity and catalytic activity was confirmed by theoretical DFT study on IL structures. High conversion of m‐cresol (95.6%) was obtained using ZnCl2 containing IL, at 393 K temperature and 2:1:1 alcohol: m‐cresol: IL molar ratio, within 5 h of reaction time. The activity and recoverability of these ILs were retained even after 8 recycles. The effect of process parameters like reaction time, temperature, reactant mole ratio and catalyst to reactant mole ratio was investigated and optimized from design of experiments results. A plausible reaction mechanism was formulated based on the product distribution and a kinetic model was developed to estimate the activation energy (45.70 kJ mol−1) and pre‐exponential factor (247.78 lit. mol−1 min−1).

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“…Nucleoside-5 -O-polyphosphates (Np X ) having more than the common one or two phosphoanhydride linkages have been the focus of studies for many years due to their important biological properties, potential as therapeutics, and biotechnological applications. Among such compounds are the nucleoside-5 -O-tetraphosphates (Np 4 ; Kore, Yang, Srinivasan, & Conrad, 2014). These have been shown to be selective agonists of the P2Y4 and P2X receptors and can act as probes for studying the substrate specificity of thymidylate transferase (Forget, Smithen, Jee, & Jakeman, 2015;Gómez-Villafuertes, Gualix, Miras-Portugal, & Pintor, 2000;Maruoka et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Nucleoside‐5′‐O‐Tetraphosphates from Activated Trimetaphosphate and Nucleoside‐5′‐O‐Monophosphates

Mohamady

Taylor

2018

CP Nucleic Acid Chemistry

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This article describes a straight‐forward chemical method for the synthesis of nucleoside‐5′‐O‐tetraphosphates, such as cytosine‐, guanosine‐, adenosine‐, and uridine‐5′‐O‐tetraphosphates, starting from the corresponding nucleoside monophosphates and trimetaphosphate, a readily available and inexpensive starting material. The procedure involves reacting the tri(tetrabutylammonium) salt of trimetaphosphate with mesitylenesulfonyl chloride and N‐methylimidazole. The resulting activated cyclic trimetaphosphate is reacted with the tetrabutylammonium salts of nucleoside monophosphates. After quenching the reaction with buffer and high‐performance liquid chromatography purification, the desired nucleoside‐5′‐O‐tetraphosphates were obtained in yields of 84% to 86%. © 2018 by John Wiley & Sons, Inc.

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Chemical and Enzymatic Synthesis of Nucleoside Tetraphosphates

Cited by 6 publications

References 0 publications

Highly Efficient Silver Nanoparticles Supported Nanocrystalline Zirconosilicate Catalyst for the Epoxidation and Hydration Reactions

Highly Efficient Silver Nanoparticles Supported Nanocrystalline Zirconosilicate Catalyst for the Epoxidation and Hydration Reactions

Synergistic Bronsted‐Lewis Acidity Effect on Upgrading Biomass‐Derived Phenolic Compounds: Statistical Optimization of Process Parameters, Kinetic Investigations and DFT Study

Synthesis of Nucleoside‐5′‐O‐Tetraphosphates from Activated Trimetaphosphate and Nucleoside‐5′‐O‐Monophosphates

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