Chemical and Biological Profiles of Novel Copper(II) Complexes Containing S-Donor Ligands for the Treatment of Cancer

Abstract

In the last years, we have synthesized some new platinum(II), palladium(II), gold(I/III) complexes with dithiocarbamato derivatives as potential anticancer drugs, to obtain compounds with superior chemotherapeutic index in terms of increased bioavailability, higher cytotoxicity, and lower side effects than cisplatin. On the basis of the obtained encouraging results, we have been studying the interaction of CuCl2 with methyl-/ethyl-/tert-butylsarcosine-dithiocarbamato moieties in a 1:2 molar ratio; we also synthesized and studied the N,N-dimethyl- and pyrrolidine-dithiocarbamato copper complexes for comparison purposes. The reported compounds have been successfully isolated, purified, and fully characterized by means of several spectroscopic techniques. Moreover, the electrochemical properties of the designed compounds have been studied through cyclic voltammetry. In addition, the behavior in solution was followed by means of UV-vis technique to check the stability with time in physiological conditions. To evaluate their in vitro cytotoxic properties, preliminary biological assays (MTT test) have been carried out on a panel of human tumor cell lines. The results show that cytotoxicity levels of all of the tested complexes are comparable or even greater than that of the reference drug (cisplatin).

Synthesis, Electronic and Optical Properties of Cobalt(II) Dithiocarbamate Fluorescent Nanowires for Optoelectronic Devices

“…5) moiety (Raja, Bhuvanesh, & Natarajan, 2012). The third and final mass loss between 490 o C to 780 o C occurs due to decomposition of the organic part of the ligand (Giovagnini et al, 2008). Co(dtc-SB) also follows the similar three stage degradation trend as observed for dtc-SB however shows better stability.…”

“…The TGA curves of Co(dtc-SB) confirm that the thermal stability of dtc-SB is enhanced on complexation with Co. I 2 doped Co(dtc-SB) decomposes sharply at about 135 o C due to the elimination of free I 2 (Giovagnini et al, 2008). However, there is no considerable change in the TG behaviour after Na doping in Co(dtc-SB).…”

Effect of Mixed Solvent System on Intramolecular Interactions of Metal Mediated Ternary Complexes of Beta-Hydroxy Ketone Derivatives and Benzotriazole Derivatives in Solution.

“…A metal ion interactions with various ligands is an extremely diversified field [1][2][3][4][5][6][7][8][9][10][11], because the interaction as well as the resulting complex can have different applications in the biological field [12][13][14][15][16][17][18][19][20][21], development of luminescent materials, color stabilizing agents for toners in color photography, catalysts, therapeutic advantage [22][23][24][25][26][27][28][29][30][31][32][33][34], in the electronic display devices [35][36][37][38][39][40][41][42][43][44][45][46][47] or fluorescent probes [48][49][50]…”

Study of chitosans interaction with Cu(II) from the corresponding sulfate and chloride salts

“…Copper complexes were found to be important materials in medicinal procedures as they have shown potential use as antimicrobial, antiviral, anti-inflammatory and antitumor agents (Giovagnini et al 2008;Dulcevscaia et al 2013;Facchin et al 2009;Urquiola et al 2008;Torre et al 2005) and enzyme inhibitors (Iakovidis et al 2011). The chelation of copper ions with chitosan has received considerable attention due to its applications in waste water treatment (Domard 1987;Huang et al 1996;Bassi et al 2000), food industries and as catalysts in a variety of reaction systems (Guibal 2005;Calo et al 2004;Adlim et al 2004;Wang et al 2005).…”