Chemical and Biological Field‐Effect Sensors for Liquids—A Status Report

Poghossian, Arshak; Schöning, Michael J.

doi:10.1002/9780470061565.hbb079

Cited by 5 publications

(3 citation statements)

References 122 publications

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“…Previous studies indicate that probing cells using electronic devices are highly sensitive to the types of interfaces, as the most critical point in signal transfer from the cell to the device is the interface between these two domains [ 31 - 34 ]. In particular, the interface should have no cleft in order to allow signal transfer.…”

Section: Resultsmentioning

confidence: 99%

Vertical nanowire probes for intracellular signaling of living cells

Lee

Kim

et al. 2014

Nanoscale Res Lett

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The single living cell action potential was measured in an intracellular mode by using a vertical nanoelectrode. For intracellular interfacing, Si nanowires were vertically grown in a controlled manner, and optimum conditions, such as diameter, length, and nanowire density, were determined by culturing cells on the nanowires. Vertical nanowire probes were then fabricated with a complimentary metal-oxide-semiconductor (CMOS) process including sequential deposition of the passivation and electrode layers on the nanowires, and a subsequent partial etching process. The fabricated nanowire probes had an approximately 60-nm diameter and were intracellular. These probes interfaced with a GH3 cell and measured the spontaneous action potential. It successfully measured the action potential, which rapidly reached a steady state with average peak amplitude of approximately 10 mV, duration of approximately 140 ms, and period of 0.9 Hz.

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Section: Resultsmentioning

confidence: 99%

Vertical nanowire probes for intracellular signaling of living cells

Lee

Kim

et al. 2014

Nanoscale Res Lett

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“…Note that there is another whole-cell bio chip family for neural sensing. Those chip integrate neural cells where the sensing is by coupling to conducting electrodes or to field effect devices [27] recording the spontaneous or triggered action potential of electrogenic cells as well as other processes, such as cell-acidification [28].…”

Section: Use Remote Methods Such Asmentioning

confidence: 99%

Optical and Electrical Interfacing Technologies for Living Cell Bio-Chips

Shacham‐Diamand¹,

Belkin²,

Rishpon³

et al. 2010

CPB

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Whole-cell bio-chips for functional sensing integrate living cells on miniaturized platforms made by micro-system-technologies (MST). The cells are integrated, deposited or immersed in a media which is in contact with the chip. The cells behavior is monitored via electrical, electrochemical or optical methods. In this paper we describe such whole-cell biochips where the signal is generated due to the genetic response of the cells. The solid-state platform hosts the biological component, i.e. the living cells, and integrates all the required micro-system technologies, i.e. the micro-electronics, micro-electro optics, micro-electro or magneto mechanics and micro-fluidics. The genetic response of the cells expresses proteins that generate: a. light by photo-luminescence or bioluminescence, b. electrochemical signal by interaction with a substrate, or c. change in the cell impedance. The cell response is detected by a front end unit that converts it to current or voltage amplifies and filters it. The resultant signal is analyzed and stored for further processing. In this paper we describe three examples of whole-cell bio chips, photo-luminescent, bioluminescent and electrochemical, which are based on the genetic response of genetically modified E. coli microbes integrated on a micro-fluidics MEMS platform. We describe the chip outline as well as the basic modeling scheme of such sensors. We discuss the highlights and problems of such system, from the point of view of micro-system-technology.

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“…In the field of semiconductor-based chemical sensors, three types of field-effect chemical sensors with the electrolyte -insulator-semiconductor (EIS) structure [1][2][3] have been studied so far; (1) Ion-sensitive field-effect transistor (IS-FET) [4,5] is a well-known semiconductor-based chemical sensor, which has been already applied for pH meters. (2) EIS capacitance sensor [6] and (3) light-addressable potentiometric sensor (LAPS) [7][8][9] are other examples of chemical sensors based on the EIS structure.…”

Section: Introductionmentioning

confidence: 99%