Chemical analysis and chemical imaging of fragrances and volatile compounds by low‐temperature plasma ionization mass spectrometry

Campbell, Dahlia I.; Dalgleish, Jon K.; Cotte-Rodríguez, Ismael; Maeno, Shuji; Cooks, R. Graham

doi:10.1002/rcm.6632

Cited by 23 publications

(21 citation statements)

References 37 publications

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“…Cooks and co-workers investigated the distribution of fragrances on surfaces with centimetre-scale resolution [36]. In contrast, we measured volatiles directly from biological tissues and improved both the technical spatial resolution [10,21], as well as the data visualisation.…”

Section: Spatial Distribution Of Volatiles and Semi-volatiles In Chilmentioning

confidence: 98%

MSI.R scripts reveal volatile and semi-volatile features in low-temperature plasma mass spectrometry imaging (LTP-MSI) of chilli (Capsicum annuum)

Gamboa-Becerra¹,

Ramı́rez-Chávez²,

Molina‐Torres³

et al. 2015

Anal Bioanal Chem

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In cartography, the combination of colour and contour lines is used to express a three-dimensional landscape on a two-dimensional map. We transferred this concept to the analysis of mass spectrometry imaging (MSI) data and developed a collection of R scripts for the efficient evaluation of .imzML archives in a four-step strategy: (1) calculation of the density distribution of mass-to-charge ratio (m/z) signals in the .imzML file and assembling of a pseudo-master spectrum with peak list, (2) automated generation of mass images for a defined scan range and subsequent visual inspection, (3) visualisation of individual ion distributions and export of relevant .mzML spectra and (4) creation of overlay graphics of ion images and photographies. The use of a Hue-Chroma-Luminance (HCL) colour model in MSI graphics takes into account the human perception for colours and supports the correct evaluation of signal intensities. Further, readers with colour blindness are supported. Contour maps promote the visual recognition of patterns in MSI data, which is particularly useful for noisy data sets. We demonstrate the scalability of MSI.R scripts by running them on different systems: on a personal computer, on Amazon Web Services (AWS) instances and on an institutional cluster. By implementing a parallel computing strategy, the execution speed for .imzML data scanning with image generation could be improved by more than an order of magnitude. Applying our MSI.R scripts ( http://www.bioprocess.org/MSI.R ) to low-temperature plasma (LTP)-MSI data shows the localisation of volatile and semi-volatile compounds in the cross-cut of a chilli (Capsicum annuum) fruit. The subsequent identification of compounds by gas and liquid chromatography coupled to mass spectrometry (GC-MS, LC-MS) proves that LTP-MSI enables the direct measurement of volatile organic compound (VOC) distributions from biological tissues.

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Section: Spatial Distribution Of Volatiles and Semi-volatiles In Chilmentioning

confidence: 98%

MSI.R scripts reveal volatile and semi-volatile features in low-temperature plasma mass spectrometry imaging (LTP-MSI) of chilli (Capsicum annuum)

Gamboa-Becerra¹,

Ramı́rez-Chávez²,

Molina‐Torres³

et al. 2015

Anal Bioanal Chem

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“…The plasma is composed of reactive species including atoms, molecules, metastable ions, radicals, high‐energy photons and electrons, and is capable of ionizing analytes via proton transfer or Penning ionization . It was demonstrated that LTP‐MS could analyze compounds in the gas phase, upon solid surfaces, and from the surface of solutions, with the analytes ranging from explosives to drugs, agrochemical residues, works of art, and organic aerosol particles . Furthermore, LTP was capable of in situ monitoring of analytes from organic reactions directly in bulk solution, and detecting oxidative cleavage of disulfide bonds for peptides …”

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confidence: 99%

Fast screening of analytes for chemical reactions by reactive low‐temperature plasma ionization mass spectrometry

Zhang

Huang

2015

Rapid Comm Mass Spectrometry

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LTP in this study serves both as an ambient ionization source for analyte identification (including reagents, intermediates and products) and as a means to produce reagent ions to assist gas-phase ion/molecule reactions. The present reactive LTP-MS method enables fast screening for several analytes from several chemical reactions, which possesses good reagent compatibility and the potential to perform high-throughput analyte screening. In addition, with the detection of various reactive intermediates (intermediates I and II of Eschweiler-Clarke methylation), the present method would also contribute to revealing and elucidating reaction mechanisms.

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“…At atmospheric pressure, the nonequilibrium DBD plasma is characterized by low gas temperature of around 30°C (Harper et al, 2008). The low temperature of the DBDI and LTP plasma gas allows soft ionization of volatile organic compounds, but the detection of lowly volatile compounds has remained less effective due to the low desorption efficiency (Benassi et al, 2013; Campbell et al, 2013; Ding et al, 2018). LTP also has enabled MSI analyses of volatile and semivolatile compounds such as fragrances and flavors spotted on filter paper as well as Chinese calligraphy patterns but with spatial resolution strongly dependent on the size of the plasma stream (Liu et al, 2010; Campbell et al, 2013).…”

Section: Laser Desorption/ablation Coupled To Ambient Ionization In Bioapplicationsmentioning

confidence: 99%

Laser Desorption/Ablation Postionization Mass Spectrometry: Recent Progress in Bioanalytical Applications

Ding

Liu

Shi

2020

Mass Spectrometry Reviews

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Lasers have long been used in the field of mass spectrometric analysis for characterization of condensed matter. However, emission of neutrals upon laser irradiation surpasses the number of ions. Typically, only one in about one million analytes ejected by laser desorption/ablation is ionized, which has fueled the quest for postionization methods enabling ionization of desorbed neutrals to enhance mass spectrometric detection schemes. The development of postionization techniques can be an endeavor that integrates multiple disciplines involving photon energy transfer, electrochemistry, gas discharge, etc. The combination of lasers of different parameters and diverse ion sources has made laser desorption/ablation postionization (LD/API) a growing and lively research community, including two‐step laser mass spectrometry, laser ablation atmospheric pressure photoionization mass spectrometry, and those coupled to ambient mass spectrometry. These hyphenated techniques have shown potentials in bioanalytical applications, with major inroads to be made in simultaneous location and quantification of pharmaceuticals, toxins, and metabolites in complex biomatrixes. This review is intended to provide a timely comprehensive view of the broadening bioanalytical applications of disparate LD/API techniques. We also have attempted to discuss these applications according to the classifications based on the postionization methods and to encapsulate the latest achievements in the field of LD/API by highlighting some of the very best reports in the 21st century. © 2020 John Wiley & Sons Ltd.

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Chemical analysis and chemical imaging of fragrances and volatile compounds by low‐temperature plasma ionization mass spectrometry

Cited by 23 publications

References 37 publications

MSI.R scripts reveal volatile and semi-volatile features in low-temperature plasma mass spectrometry imaging (LTP-MSI) of chilli (Capsicum annuum)

MSI.R scripts reveal volatile and semi-volatile features in low-temperature plasma mass spectrometry imaging (LTP-MSI) of chilli (Capsicum annuum)

Fast screening of analytes for chemical reactions by reactive low‐temperature plasma ionization mass spectrometry

Laser Desorption/Ablation Postionization Mass Spectrometry: Recent Progress in Bioanalytical Applications

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