Chemical analysis and anti-aging properties of Greek pollen

Graikou, Konstantia; Aligiannis, Nektarios; Chondrogianni, Niki; Kapeta, Suzanne; Gonos, Efstathios S.; Chinou, İoanna

doi:10.1055/s-0028-1084582

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bee pollen is the most popular natural health food in the world, and polysaccharide is the main bioactive components. Studies have shown that bee pollen polysaccharides have different functions, such as immunomodulation (Li et al, 2009), hypoglycemic (Gong et al, 2017), hypolipidemic (Denisow et al, 2016), anti-aging (Graikou et al, 2008) and anti-tumor (Wang et al, 2013). In our previous work, bee pollen polysaccharide from Rosa rugosa Thunb.…”

Section: Introductionmentioning

confidence: 89%

Bee Pollen Polysaccharide From Rosa rugosa Thunb. (Rosaceae) Promotes Pancreatic β-Cell Proliferation and Insulin Secretion

Yang

Chen

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Insufficient pancreatic β-cell or insulin-producing β-cell are implicated in all types of diabetes mellitus. Our previous studies showed bee pollen polysaccharide RBPP-P improves insulin resistance in type 2 diabetic mice by inhibiting liver fat deposition. However, its potential of regulating β-cell function and integrity is not fully known. Herein, we observed that β-cell proliferation (n = 10), insulin synthesis (n = 5, p = 0.01684) and insulin incretion (n = 5, p = 0.02115) were intensely activated in MIN6 cells when treatment with RBPP-P. In alloxan-induced diabetic mice, oral administration of RBPP-P (n = 10) effectively decreased the blood glucose (p = 0.0326), drink intake (p < 0.001) and urine (p < 0.001). It directly stimulated phosphorylation of p38 (p = 0.00439), ERK (p = 0.02951) and AKT (p = 0.0072) to maintain the islet function and mass. Thus, our data suggest that RBPP-P is a natural compound to regulate β-cell proliferation and function, indicating it might have therapeutic potential against type 1 diabetes.

show abstract