Chemical activity and distribution of emerging pollutants: Insights from a multi-compartment analysis of a freshwater system

Inostroza, Pedro A.; Massei, R; Wild, Romy; Krauß, Martin; Brack, Werner

doi:10.1016/j.envpol.2017.08.015

Cited by 32 publications

(37 citation statements)

References 49 publications

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“…The hydrophobic ionizable compounds such as phenolic pesticides may destroy the electro-chemical gradient of protons through interaction with the energy cycle. The process is achieved via short-circuiting, which in response may affect their bio-availability and bioaccumulation, which further enhances their sorption in organic molecules [21]. Therefore, the compounds with hydrophobic properties have the ability to change membrane energization causing membrane perturbation that in response exerts narcotic-level effects that reflect baseline toxicity.…”

Section: Resultsmentioning

confidence: 99%

“…Some banned herbicides with acidic potential (i.e., trifluoroacetic and chloroacetic acids) still exist as solvent degradation products [56][57][58]. Since polar compounds have strong H-donor/H-acceptor ion interactions [21], they exhibit quite low IEC (ionization energy compounds) values as compared to non-polar compounds. The polar narcotic compounds exert toxicity (in terms of 50% internal lethal concentration (ILC 50 )) in a range of 0.6 to 2 mmol/kg (based on body weight) [19].…”

Section: Resultsmentioning

confidence: 99%

“…However, the effective concentration in the membrane matrix was indistinguishable in an invitro test among the polar and non-polar compounds; specifically, where the dependency is only on an energytransducing membrane in different biological testing units, as the chemicals target lipid protein embedded in the membrane matrix [19]. However, the most important factor related to whole body concentration in both (polar and non-polar) compounds is the distribution of the environmental pollutants between target and nontarget compartments [21].…”

Section: Resultsmentioning

confidence: 99%

“…In contrast, chemicals with a specific mode of action have not only specific target-oriented effects (based on the specific receptors), but the non-specific components (due to the hydrophobic nature) also contribute to the overall toxic effects [18]. Hydrophobic potential of environmental pollutants can be calculated from octanol-water partition coefficients (log K ow ) [20][21][22]. In an aqueous environment, the concentration of highly hydrophobic chemicals remains quite low, and therefore their specific toxic effects may not be obvious [23]; whereas nonspecific toxic effects will remain due to hydrophobicity and will be additive [24,25].…”

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confidence: 99%

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Role of Hydrophobicity in Bio-Accessibility of Environmental Pollutants Among Different Organisms

Ashraf¹,

Bakhat²,

Shah³

et al. 2020

Pol. J. Environ. Stud.

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In the modern world, organic chemicals have extensively been used in a variety of industries, including pharmaceuticals, fuels, beverages, foods and agricultural products [1-3]. However, limited information is available about their potential risk to the environment-especially in developing countries because of time and economic constraints [4-6]. In aquatic systems, it is often difficult to make relationships of cause and consequences for aquatic life [7]. So far, different efforts have been made to look into other avenues, i.e., physico-chemical properties, different biological barriers and modelling of existing data to address the toxic potential of pollutants [8-12]. Among different physico-chemical properties (e.g., adsorption forces at surface, solubility, hydrogen bonding, lone-pair electrons, chemical polarity and polarizability among different atoms and molecules)

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Role of Hydrophobicity in Bio-Accessibility of Environmental Pollutants Among Different Organisms

Ashraf¹,

Bakhat²,

Shah³

et al. 2020

Pol. J. Environ. Stud.

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“…The occurrence of CECs in freshwater ecosystems has been shown to cause adverse effects including long-term changes in the aquatic community composition (Liess & Von Der Ohe, 2005). Several studies have documented the global occurrence of CECs in freshwater resources (Luo et When CECs are discharged into the aquatic ecosystem, they undergo equilibrium partitioning between water and sediments and may accumulate in biota according to their hydrophobicity and toxicokinetics in the organism (Di Toro et al 1991;Mayer and Holmstrup 2008;Ashauer et al 2011;Inostroza et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Multi-compartment chemical characterization and risk assessment of chemicals of emerging concern in freshwater systems of western Kenya

Kandie

Krauß

Massei

et al. 2020

Preprint

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Background: Within the last decades, there has been increasing research on the occurrence of chemicals of emerging concern (CECs) in aquatic ecosystems due to their potential adverse effects on freshwater organisms and risk to human health. However, information on CECs in freshwater environments in sub-Saharan countries is very limited. Here, we investigated the occurrence of CECs in snails and sediments collected from 48 sites within the Lake Victoria South Basin, Kenya, which have been previously investigated for water contamination. Samples were analyzed by liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS) with a target list of 429 compounds. Results: In total, 30 compounds have been detected in snails and 78 in sediment samples, compared to 79 previously identified compounds in water. By extending the monitoring of CECs to snails and sediments, we found 68 compounds that were not previously detected in water. These compounds include the anti-cancer drug anastrozole, detected for the first time in the Kenyan environment. Individual compound concentrations were detected up to 480 ng/g wet weight (N-ethyl-o-toluenesulfonamide) in snails and 110 ng/g organic carbon (pirimiphos-methyl) in sediments. Higher contaminant concentrations were found in agricultural sites than in areas not impacted by anthropogenic activities. Crustaceans were the organisms at greatest toxic risk from sediment contamination (toxic unit (TU) up to 0.99) with diazinon and pirimiphos-methyl driving this risk. Acute and chronic risks to algae were driven by diuron (TU up to 0.24), whereas fish were found to be at low to no acute risk (TU up to 0.007). Conclusions: The compound classes present at highest frequencies in all matrices were pesticides and biocides. This study shows substantial contamination of surface water in rural western Kenya. By filling data gaps on contamination of sediments and aquatic biota, our study reveals that CECs pose a substantial risk on environmental health in Kenya demanding for monitoring and mitigation.

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Sources and Fate of the Antiandrogenic Fluorescent Dye 4‐Methyl‐7‐Diethylaminocoumarin in Small River Systems

Muschket

Brack

Inostroza

et al. 2021

Enviro Toxic and Chemistry

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Recently, the potent antiandrogen 4‐methyl‐7‐diethylaminocoumarin (C47) and its potential transformation products 4‐methyl‐7‐ethylaminocoumarin (C47T1) and 4‐methyl‐7‐aminocoumarin (C47T2) were identified as novel environmental contaminants. We assessed for the first time the sources, distribution, and fate of these compounds in aquatic systems using the Holtemme River (Saxony‐Anhalt, Germany), which is a hotspot for these contaminants. To this end, wastewater‐treatment plant (WWTP) influent and effluent samples, surface water samples over 3 years, and the longitudinal profiles in water, sediment, and gammarids were analyzed. From the longitudinal profile of the river stretch, the WWTP of Silstedt was identified as the sole point source for these compounds in the River Holtemme, and exposure concentrations in the low micrograms per liter range could be recorded continuously over 3 years. Analysis of WWTP influent and effluent showed a transformation of approximately half of the C47 into C47T1 and C47T2 but no complete removal. A further attenuation of the three coumarins after discharge into the river could be largely attributed to dilution, while transformation was only approximately 20%, thus suggesting a significant persistence in aquatic systems. Experimentally derived partitioning coefficients between water and sediment organic carbon exceeded those predicted using the OPERA quantitative structure–activity relationship tools and polyparameter linear free‐energy relationships by up to 93‐fold, suggesting cation binding as a significant factor for their sorption behavior. Near‐equilibrium conditions between water and sediment were not observed close to the emitting WWTP but farther downstream in the river. Experimental and predicted bioaccumulation factors for gammarids were closely matching, and the concentrations in field‐sampled gammarids were close to steady state with exposure concentrations in the water phase of the river. Environ Toxicol Chem 2021;40:3078–3091. © 2021 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

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Chemical activity and distribution of emerging pollutants: Insights from a multi-compartment analysis of a freshwater system

Cited by 32 publications

References 49 publications

Role of Hydrophobicity in Bio-Accessibility of Environmental Pollutants Among Different Organisms

Role of Hydrophobicity in Bio-Accessibility of Environmental Pollutants Among Different Organisms

Multi-compartment chemical characterization and risk assessment of chemicals of emerging concern in freshwater systems of western Kenya

Sources and Fate of the Antiandrogenic Fluorescent Dye 4‐Methyl‐7‐Diethylaminocoumarin in Small River Systems

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