Chemical Acidification of Wounds

LeVeen, Harry H.; Falk, Gerhard; Borek, Bartłomiej; Diaz, C.Jimenez; Lynfield, Y; Wynkoop, B J; Mabunda, G A; Rubricius, J L; Christoudias, G C

doi:10.1097/00000658-197312000-00011

Cited by 159 publications

(57 citation statements)

References 11 publications

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“…The reasons for improved wound healing at an acid environment have earlier been explained by better release of oxygen due to a shift in the hemoglobin‐oxyhemoglobin dissociation curve at lower pH 25 . This interpretation agrees with the finding of decreased fibroblast proliferation in wound models, where the effect of increased pH has been tested 26 .…”

Section: Discussionsupporting

confidence: 82%

Fibroblast proliferation due to exposure to a platelet concentrate in vitro is pH dependent

Liu

Kalén

Risto

et al. 2002

Wound Repair Regeneration

212

144

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The influence of platelet-rich plasma lysates on fibroblast proliferation was studied in culture. Cells were exposed to platelet lysates that had been preincubated at different pHs (5.0, 7.1, and 7.6). Proliferation was evaluated with the MTT assay and incorporation of [3H]thymidine into macromolecules, while type I collagen production was assayed by Western blotting. Enzyme-linked immunosorbent assays were used to determine platelet-derived growth factor and transforming growth factor-beta concentrations. Platelets preincubated in an acidic environment (pH 5.0) induced the highest degree of fibroblast proliferation, and the concentration of platelet-derived growth factor in the different treated lysates was the highest at that particular pH. The concentration of transforming growth factor-beta, however, was lower after incubation at pH 5.0 than at either pH 7.1 or 7.6. These findings may be relevant to normal wound healing in vivo and useful in the treatment of wounds and delayed healing processes.

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Section: Discussionsupporting

confidence: 82%

Fibroblast proliferation due to exposure to a platelet concentrate in vitro is pH dependent

Liu

Kalén

Risto

et al. 2002

Wound Repair Regeneration

212

144

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“…[ 71 ] In addition, bacterial infection also leads to the production of ammonia which will raise the pH of the wounds. [ 77 ] Because pH is an indicator of wound state, many studies have focused on developing GF delivery systems that can respond to specific pH levels. Banerjee et al fabricated a pH‐sensitive poly ( N ‐isopropylacrylamide‐ co ‐acrylic acid) (poly(NIPAm‐ co ‐AAc)) hydrogel to deliver VEGF and EGF.…”

Section: Stimuli‐responsive Growth Factor Delivery Systems In Tissue mentioning

confidence: 99%

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Jiang

Zhou

et al. 2020

Adv Healthcare Materials

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Growth factors (GFs) play a crucial role in directing stem cell behavior and transmitting information between different cell populations for tissue regeneration. However, their utility as therapeutics is limited by their short half‐life within the physiological microenvironment and significant side effects caused by off‐target effects or improper dosage. “Smart” materials that can not only sustain therapeutic delivery over a treatment period but also facilitate on‐demand release upon activation are attracting significant interest in the field of GF delivery for tissue engineering. Three properties are essential in engineering these “smart” materials: 1) the cargo vehicle protects the encapsulated therapeutic; 2) release is targeted to the site of injury; 3) cargo release can be modulated by disease‐specific stimuli. The aim of this review is to summarize the current research on stimuli‐responsive materials as intelligent vehicles for controlled GF delivery; Five main subfields of tissue engineering are discussed: skin, bone and cartilage, muscle, blood vessel, and nerve. Challenges in achieving such “smart” materials and perspectives on future applications of stimuli‐responsive GF delivery for tissue regeneration are also discussed.

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“…The relatively acidic environment created by citric acid is also beneficial for wound healing in other aspects [106]: for example, by promoting oxygen release to the wound bed. Studies have revealed lowering pH by 0.9 units resulted in a 5-fold increase in oxygen release from hemoglobin, greatly affecting the available supply of oxygen to tissues [107]. Apart from the pH effect, more importantly, sodium citrate has also been found to possess superior antimicrobial effects against a wide range of oral or blood derived [101, 108], Gram-positive or Gram-negative, bacterial or fungus microbials.…”

Section: Biology Considerations For Biomaterials Design and Applicationmentioning

confidence: 99%

Citrate chemistry and biology for biomaterials design

Gerhard

Lü

et al. 2018

Biomaterials

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Leveraging the multifunctional nature of citrate in chemistry and inspired by its important role in biological tissues, a class of highly versatile and functional citrate-based materials (CBBs) has been developed via facile and cost-effective polycondensation. CBBs exhibiting tunable mechanical properties and degradation rates, together with excellent biocompatibility and processability, have been successfully applied in vitro and in vivo for applications ranging from soft to hard tissue regeneration, as well as for nanomedicine designs. We summarize in the review, chemistry considerations for CBBs design to tune polymer properties and to introduce functionality with a focus on the most recent advances, biological functions of citrate in native tissues with the new notion of degradation products as cell modulator highlighted, and the applications of CBBs in wound healing, nanomedicine, orthopedic, cardiovascular, nerve and bladder tissue engineering. Given the expansive evidence for citrate's potential in biology and biomaterial science outlined in this review, it is expected that citrate based materials will continue to play an important role in regenerative engineering.

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Chemical Acidification of Wounds

Cited by 159 publications

References 11 publications

Fibroblast proliferation due to exposure to a platelet concentrate in vitro is pH dependent

Fibroblast proliferation due to exposure to a platelet concentrate in vitro is pH dependent

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Citrate chemistry and biology for biomaterials design

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