Chemerin Signaling in Cancer

Treeck, Oliver; Buechler, Christa

doi:10.3390/cancers12113085

Cited by 6 publications

(4 citation statements)

References 19 publications

(37 reference statements)

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“…Chemerin has a significant function in cancer development, yet its role in carcinogenesis is poorly understood. It turns out that the concentration of chemerin can be decreased or increased during the development of many cancers and can show both protective and promoting effects on the development of carcinogenesis [ 232 , 243 , 244 ]. The potential role of chemerin in carcinogenesis is shown in Figure 7 .…”

Section: Chemerinmentioning

confidence: 99%

The Role of Selected Adipocytokines in Ovarian Cancer and Endometrial Cancer

Stępień

Olczyk

Gola

et al. 2023

Cells

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Due to their multidirectional influence, adipocytokines are currently the subject of numerous intensive studies. Significant impact applies to many processes, both physiological and pathological. Moreover, the role of adipocytokines in carcinogenesis seems particularly interesting and not fully understood. For this reason, ongoing research focuses on the role of these compounds in the network of interactions in the tumor microenvironment. Particular attention should be drawn to cancers that remain challenging for modern gynecological oncology—ovarian and endometrial cancer. This paper presents the role of selected adipocytokines, including leptin, adiponectin, visfatin, resistin, apelin, chemerin, omentin and vaspin in cancer, with a particular focus on ovarian and endometrial cancer, and their potential clinical relevance.

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Section: Chemerinmentioning

confidence: 99%

The Role of Selected Adipocytokines in Ovarian Cancer and Endometrial Cancer

Stępień

Olczyk

Gola

et al. 2023

Cells

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“…The dual role of chemerin in cancer development is that high serum chemerin levels may indicate increased survival in patients with tumors such as breast cancer, ovarian cancer, hepatocellular carcinoma (HCC), and adrenocortical carcinoma (ACC), while high chemerin expression suggests poor prognosis in patients with gastric cancer and non-small cell lung cancer (NSCLC) (171). For PC, Kiczmer et al ( 53) evaluated serum chemerin levels in 27 patients with PC, 10 patients with CP, and 36 control volunteers and found that chemerin levels were significantly elevated in patients with PC (Table 1).…”

Section: Chemerinmentioning

confidence: 99%

The Role of Adipokines in Pancreatic Cancer

Wang

Ding

et al. 2022

Front. Oncol.

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In modern society, inappropriate diets and other lifestyle habits have made obesity an increasingly prominent health problem. Pancreatic cancer (PC), a kind of highly aggressive malignant tumor, is known as a silent assassin and is the seventh leading cause of cancer death worldwide, pushing modern medicine beyond help. Adipokines are coming into notice because of the role of the intermediate regulatory junctions between obesity and malignancy. This review summarizes the current evidence for the relationship between highly concerning adipokines and the pathogenesis of PC. Not only are classical adipokines such as leptin and adiponectin included, but they also cover the recognized chemerin and osteopontin. Through a summary of the biological functions of these adipokines as well as their receptors, it was discovered that in addition to their basic function of stimulating the biological activity of tumors, more studies confirm that adipokines intervene in the progression of PC from the viewpoint of tumor metabolism, immune escape, and reprogramming of the tumor microenvironment (TME). Besides endocrine function, the impact of white adipose tissue (WAT)-induced chronic inflammation on PC is briefly discussed. Furthermore, the potential implication of the acknowledged endocrine behavior of brown adipose tissue (BAT) in relation to carcinogenesis is also explored. No matter the broad spectrum of obesity and the poor prognosis of PC, supplemental research is needed to unravel the detailed network of adipokines associated with PC. Exploiting profound therapeutic strategies that target adipokines and their receptors may go some way to improving the current worrying prognosis of PC patients.

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“…(Jacenik & Fichna, 2020), and its main functions were initially found in immune response, adipogenesis, as well as glucose and lipid metabolism (Jacenik & Fichna, 2020). Recently, Chemerin has been reported to be involved in the pathogenesis of inflammation and in a wide range of diseases, such as cancer, preeclampsia, and polycystic ovary syndrome (Luo et al, 2021; Quan et al, 2021; Treeck & Buechler, 2020; Yue et al, 2023). The serum contents of Chemerin are significantly elevated in various inflammatory diseases and contribute to the development of inflammation by aggregating different types of inflammatory cells (chemotaxis of dendritic cells and macrophages) at the site of inflammation (Su et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Chemerin and IL‐17 are potential predictors and Chemerin silencing alleviates inflammatory response and bone remodeling in chronic rhinosinusitis

Xie,

Bai,

Zhou

et al. 2023

Chem Biol Drug Des

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Chronic rhinosinusitis (CRS) is an inflammatory disease of paranasal sinuses. This study is formulated to explore the roles of pro‐inflammatory factors Chemerin and interleukin‐17 (IL‐17) in CRS. Patients suffering from CRS without/with nasal polyps (CRSsNP/CRSwNP), along with volunteers, were recruited. CRS rabbit models were constructed by Staphylococcus aureus infection and rabbits were injected with lentiviral vectors of short hairpin RNA‐targeting Chemerin (shChemerin), followed by micro‐computed tomography (CT) scan. Levels of Chemerin and IL‐17 were determined, and histopathological lesions were observed in subjects and CRS rabbits. Correlations between Chemerin/IL‐17 level and Lund‐Mackay/Lund‐Kennedy scores of subjects and the predictive value of Chemerin or IL‐17 for CRS were analyzed. In CRS patients and rabbits, inflammatory degrees and the level of Chemerin/IL‐17 were increased in pathological tissues or plasma, while Chemerin silencing alleviated CRS symptoms of CRS rabbits. Chemerin and IL‐17 were mainly located in the immune cells of pathological tissues and presented the positive correlation with Lund‐Mackay/Lund‐Kennedy score of CRS patients. Also, they showed high predictive value for CRS. Micro‐CT scan uncovered that CRS rabbits had increased bone remodeling, which was alleviated by Chemerin silencing. Collectively, Chemerin and IL‐17 are potential predictors and Chemerin silencing alleviates inflammatory response and bone remodeling in chronic rhinosinusitis.

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Chemerin Signaling in Cancer

Abstract: The multifunctional adipokine chemerin exerts key functions in inflammation, adipogenesis and glucose homeostasis[...]

Cited by 6 publications

References 19 publications

The Role of Selected Adipocytokines in Ovarian Cancer and Endometrial Cancer

The Role of Selected Adipocytokines in Ovarian Cancer and Endometrial Cancer

The Role of Adipokines in Pancreatic Cancer

Chemerin and IL‐17 are potential predictors and Chemerin silencing alleviates inflammatory response and bone remodeling in chronic rhinosinusitis

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