Chelerythrine inhibits the progression of glioblastoma by suppressing the TGFB1-ERK1/2/Smad2/3-Snail/ZEB1 signaling pathway

Zhu, Mingwei; Niu, Jiamei; Jiang, Jian; Dong, Tianxiu; Chen, Yaodong; Yang, Xiuhua; Liu, Pengfei

doi:10.1016/j.lfs.2022.120358

Cited by 11 publications

(7 citation statements)

References 58 publications

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“…Interestingly, Mingwei Zhu et al discovered the inhibitory effects of CHE on the progression of glioblastoma. Their research demonstrated that CHE effectively suppresses the TGFB1-ERK1/2/Smad2/3-Snail/ZEB1 signaling pathway, thereby impeding the development of glioblastoma [ 33 ]. MAG significantly inhibits the proliferation of prostate cancer cells by altering metabolic biomarkers to disrupt the growth and proliferation of prostate cancer cells [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

The Therapeutic Potential of Four Main Compounds of Zanthoxylum nitidum (Roxb.) DC: A Comprehensive Study on Biological Processes, Anti-Inflammatory Effects, and Myocardial Toxicity

Li,

Wang,

Liu

et al. 2024

Pharmaceuticals

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Zanthoxylum nitidum (Roxb.) DC. (Z. nitidum) is a traditional Chinese medicinal plant that is indigenous to the southern regions of China. Previous research has provided evidence of the significant anti-inflammatory, antibacterial, and anticancer properties exhibited by Z. nitidum. The potential therapeutic effects and cardiac toxicity of Z. nitidum remain uncertain. The aim of this research was to investigate the potential therapeutic properties of the four main compounds of Z. nitidum in cardiovascular diseases, their impact on the electrical activity of cardiomyocytes, and the underlying mechanism of their anti-inflammatory effects. We selected the four compounds from Z. nitidum with a high concentration and specific biological activity: nitidine chloride (NC), chelerythrine chloride (CHE), magnoflorine chloride (MAG), and hesperidin (HE). A proteomic analysis was conducted on the myocardial tissues of beagle dogs following the administration of NC to investigate the role of NC in vivo and the associated biological processes. A bioinformatic analysis was used to predict the in vivo biological processes that MAG, CHE, and HE were involved in. Molecular docking was used to simulate the binding between compounds and their targets. The effect of the compounds on ion channels in cardiomyocytes was evaluated through a patch clamp experiment. Organ-on-a-chip (OOC) technology was developed to mimic the physiological conditions of the heart in vivo. Proteomic and bioinformatic analyses demonstrated that the four compounds of Z. nitidum are extensively involved in various cardiovascular-related biological pathways. The findings from the patch clamp experiments indicate that NC, CHE, MAG, and HE elicit a distinct activation or inhibition of the IK1 and ICa-L in cardiomyocytes. Finally, the anti-inflammatory effects of the compounds on cardiomyocytes were verified using OOC technology. NC, CHE, MAG, and HE demonstrate anti-inflammatory effects through their specific interactions with prostaglandin-endoperoxide synthase 2 (PTGS2) and significantly influence ion channels in cardiomyocytes. Our study provides a foundation for utilizing NC, CHE, MAG, and HE in the treatment of cardiovascular diseases.

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Section: Discussionmentioning

confidence: 99%

The Therapeutic Potential of Four Main Compounds of Zanthoxylum nitidum (Roxb.) DC: A Comprehensive Study on Biological Processes, Anti-Inflammatory Effects, and Myocardial Toxicity

Li,

Wang,

Liu

et al. 2024

Pharmaceuticals

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“…Natural alkaloids have good antitumor activity and have been increasingly evaluated in preclinical studies in recent years. In general, natural alkaloids can exert antitumor effects by regulating reactive oxygen species, inducing apoptosis and cell cycle arrest in tumor cells, and regulating autophagy and epithelial-mesenchymal transition [20] , [21] , [22] , [23] . CVB is a natural triterpenoid alkaloid and exerts noticeable antitumor effects on several types of tumors, such as clear cell renal cell carcinoma and lung cancer [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

DNA repair pathways-targeted cyclovirobuxine inhibits castration-resistant prostate cancer growth by promoting cell apoptosis and cycle arrest

Gao

Zhu²,

Shao³

et al. 2023

Translational Oncology

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“…Unfortunately, owing to the novel coronavirus epidemic, we were unable to conduct in vivo experiments. However, previous studies have shown that CHE still has a good therapeutic effect in in vivo studies of glioma, non-small cell lung cancer, and Dalton's lymphoma [ 28 , 29 ], suggesting that CHE may also have good pharmacological activity in in vivo studies of GC. In addition, chemotherapy tolerance is one of the most important factors leading to poor prognosis in patients with gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology, molecular docking and experimental verification help unravel chelerythrine's potential mechanism in the treatment of gastric cancer

Kai,

Han-bing,

Bing-lin

et al. 2023

Heliyon

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Chelerythrine inhibits the progression of glioblastoma by suppressing the TGFB1-ERK1/2/Smad2/3-Snail/ZEB1 signaling pathway

Cited by 11 publications

References 58 publications

The Therapeutic Potential of Four Main Compounds of Zanthoxylum nitidum (Roxb.) DC: A Comprehensive Study on Biological Processes, Anti-Inflammatory Effects, and Myocardial Toxicity

The Therapeutic Potential of Four Main Compounds of Zanthoxylum nitidum (Roxb.) DC: A Comprehensive Study on Biological Processes, Anti-Inflammatory Effects, and Myocardial Toxicity

DNA repair pathways-targeted cyclovirobuxine inhibits castration-resistant prostate cancer growth by promoting cell apoptosis and cycle arrest

Network pharmacology, molecular docking and experimental verification help unravel chelerythrine's potential mechanism in the treatment of gastric cancer

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