Chelation of zinc(II) with poly(γ-glutamic acid) in aqueous solution: kinetics, binding constant, and its antimicrobial activity

Akter, Bakul; Khan, Ariful Islam; Karmaker, Subarna; Ghosh, Pollob; Saha, Sajal; Polash, Shakil Ahmed; Islam, Zahidul; Sarker, Satya Ranjan; Hossain, Md. Sharif; Yasui, Hiroyuki; Saha, Tapan Kumar

doi:10.1007/s00289-020-03165-9

Cited by 7 publications

(5 citation statements)

References 33 publications

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“…It was speculated that the concentration of OH − in the solution increases, which enhances the deprotonation of carboxyl groups on CP[5]AK and makes it easier for 2 to enter the electron-rich cavity of CP[5]AK through electrostatic interaction to form a stable inclusion complex. 70,71…”

Section: Resultsmentioning

confidence: 99%

“…It was speculated that the concentration of OH À in the solution increases, which enhances the deprotonation of carboxyl groups on CP [5]AK and makes it easier for 2 to enter the electron-rich cavity of CP [5]AK through electrostatic interaction to form a stable inclusion complex. 70,71 The cytotoxicity of NM is attributed mainly to the highly reactive intermediate 2. The highly reactive intermediate 2 subsequently imparts nucleophilic attacks on the N7 position of the guanine residue in the DNA to induce DNA alkylation (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Supramolecular detoxification of nitrogen mustardviahost–guest encapsulation by carboxylatopillar[5]arene

Zhou

Chen

et al. 2023

J. Mater. Chem. B

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Supramolecular detoxification of nitrogen mustardviahost–guest encapsulation by carboxylatopillar[5]arene

Zhou

Chen

et al. 2023

J. Mater. Chem. B

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“…In fact, toward the Ti-MXene nanosheets in the PAM layer, there are lots of hydrophilic hydroxyl groups . More importantly, the γ-PGA owns a long-lasting moisturizing ability due to the presence of a large number of carboxyl groups that could interact with water molecules through hydrogen bonding . The introduction of γ-PGA effectively enhances the interaction between ANFs and Ti-MXene, giving the ternary PAM composite layer a good mechanical property.…”

Section: Results and Discussionmentioning

confidence: 99%

“…21 More importantly, the γ-PGA owns a long-lasting moisturizing ability due to the presence of a large number of carboxyl groups that could interact with water molecules through hydrogen bonding. 30 The introduction of γ-PGA effectively enhances the interaction between ANFs and Ti-MXene, giving the ternary PAM composite layer a good mechanical property. After that, the bare Zn and PAM@Zn foils were further immersed into the 2 M ZnSO 4 electrolyte for 5 days to investigate the side reactions.…”

Section: Resultsmentioning

confidence: 99%

Surface Engineering with Interfacial Poly(glutamic acid)/MXene/Aramid Nanofibers Protective Layer for Dendrite-Free Zinc Anodes

et al. 2023

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Aqueous zinc-ion batteries (AZIBs) use zinc metal as anodes are expected to be used for large-scale energy storage due to their good safety, low cost, environmental friendliness, etc. However, the zinc dendrite growth and associated side reactions seriously cause low Coulomb efficiency and reduce the cycle life of AZIBs, finally hampering further practical application. Herein, the γ-poly(glutamic acid) (γ-PGA)/aramid nanofibers (ANFs)/ MXene (PAM) protection layer was designed toward a dendrite-free Zn metal anode. The PAM layer with a three-dimensional (3D) network formed by strong hydrogen bonding interactions effectively inhibits the growth of zinc dendrites, corrosion of the electrolyte, and hydrogen precipitation due to the reduced nucleation overpotential, which facilitates uniform galvanization/de-zincification. At a current density of 0.1 mA•cm −2 and 0.1 mAh•cm −2 , the cycle life of PAM@Zn//PAM@Zn symmetric cell could extend to 3500 h. Meanwhile, the PAM@Zn//V 2 O 5 full cell could also exhibit a capacity retention of 82.49% after 1500 cycles at 1 C. This strategy of designing a polymer-based composite protection layer by integrating the advantages of different materials opens up more possibilities for the development of a dendrite-free Zn anode.

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“…The studied C010DS-Zn was zinc-carrying gamma-polyglutamate conjugated with 1 Cy5.5 fluorescent reporter, 2 folate-(ester)-PEG4-NH3, 2 cRGDfK-(ester)-PEG4-NH3, and 10 pyrithione-(disulfide)-PEG3-NH3 per 32 kDa (Mw) polymer backbone, with the zinc loaded at 7 Zn 2+ to 1 pyrithione (Pyr) sidechain molar ratio via backbone complexation ( 11 ) ( Figure 1B ). In vitro cytotoxicity of C010DS-Zn and relevant control groups including zinc sulfate, zinc sulfate-sodium Pyr mixture at 7 Zn 2+ to 1 Pyr molar ratio modelling the C010DS-Zn payload (7Zn-1Pyr), and C005D-Zn (a positive control compound with identical structure and zinc content minus the Pyr-sidechain modifications)( Figure 1B ) were therefore tested.…”

Section: Resultsmentioning

confidence: 99%

Parthanatos-inducing zinc agent C010DS-Zn elicits anti-tumor immune responses involving T cells and macrophagesin vivo

Chung¹,

Z²,

Wm³

et al. 2021

Preprint

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Immune checkpoint inhibitors opened a new horizon in cancer therapy by enabling durable and complete responses in patients, but their wider application against general solid cancers has been hampered by the lack of a broadly acting anti-cancer immune response initiating agents. Parthanatos is a previously unexplored immunogenic programmed necrosis mechanism that is triggered by the hyperactivation of PARP DNA repair and executed by an efficient DNA-fragmentation mechanism. We developed a proprietary macromolecular zinc complex agent C010DS-Zn that efficiently induced parthanatos against 4T1 murine cancer cells in vitro, which was characterized as PARP-mediated necrotic death with massive DNA damages. Ex vivo screening of its cytotoxicity against a panel of 53 low-passage human solid cancer PDX tumor fragments demonstrated its consistent delivery of characteristically DNA-damaging cell death that was unseen in the corresponding apoptosis positive controls. Further characterization of its in vivo treatment effects versus the immunosuppressive 4T1-Balb/c and immunogenic CT26-Balb/c syngeneic cancer models showed that sufficiently high intravenous C010DS-Zn treatments led to robust initiation of the tumor-suppressed antitumor immune compartments such as T cells and macrophages. At lower non-anticancer doses, C010DS-Zn treatment still led to significantly reduced macrophage content and inflammation in the 4T1 tumor, suggesting its potential utility against macrophage-mediated inflammations such as those seen in MIS-C or COVID19. Given the observation of its low serum bioavailability in a rat pharmacokinetic study, these results suggest potential development opportunities for C010DS-Zn to become a widely applicable immune initiation agent with chemo-like broad applicability upon its pharmacokinetic improvements.

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Chelation of zinc(II) with poly(γ-glutamic acid) in aqueous solution: kinetics, binding constant, and its antimicrobial activity

Cited by 7 publications

References 33 publications

Supramolecular detoxification of nitrogen mustardviahost–guest encapsulation by carboxylatopillar[5]arene

Supramolecular detoxification of nitrogen mustardviahost–guest encapsulation by carboxylatopillar[5]arene

Surface Engineering with Interfacial Poly(glutamic acid)/MXene/Aramid Nanofibers Protective Layer for Dendrite-Free Zinc Anodes

Parthanatos-inducing zinc agent C010DS-Zn elicits anti-tumor immune responses involving T cells and macrophagesin vivo

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