Chelation for autism spectrum disorder (ASD)

James, Stephen; Stevenson, Shawn; Silove, Natalie; Williams, Katrina

doi:10.1002/14651858.cd010766.pub2

Cited by 44 publications

(36 citation statements)

References 52 publications

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“…Although, there is no evidence of the efficacy and potential side effects of this chelation therapy in ASD, the heavy metal ratio is quite high in ASD patients and thus, it is suggested that there is a relationship between the heavy metals ratio and ASD (Pelch et al 2019). However, reviewers of the chelation therapy concluded that this treatment is not recommended for individuals with ASD, and that risks associated with chelation therapy outweigh any potential benefits (Davis et al 2012;James et al 2015;DeFilippis 2019). Chelation agents can bind ions nonspecifically, and thus cause a decrement in the plasma levels of calcium, iron, and magnesium as well.…”

Section: Resultsmentioning

confidence: 99%

“…Chelation agents can bind ions nonspecifically, and thus cause a decrement in the plasma levels of calcium, iron, and magnesium as well. This may associated with hypertension, hypotension, cardiac arrhythmias, and hypocalcemia, the latter of which can be fatal (James et al 2015;DeFilippis 2019). In this context, pharmacists can determine and monitor the problems related to the decreased levels of these ions, and can raise the awareness of the patients in relation to the symptoms of these deficiencies.…”

Section: Resultsmentioning

confidence: 99%

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The role of pharmacists in the management of autism spectrum disorder: A survey to determine the knowledge and perception of the parents

Kara¹,

Cakir²,

Durman³

et al. 2019

Istanbul J Pharm

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder, which is characterized by persistent deficits in social communication and social interaction, limitations and deviations in verbal and nonverbal skills, repetitive patterns of behavior, interests or activities. The worldwide prevalence of ASD has been steadily increasing in recent decades. In 2016, the USA National Health Center for Health Statistics reported that ASD could be found in 1 out of 36 children (Christensen et al. 2016; Sharma et al. 2018). Due to the large variation in deficiencies and the deviations in symptoms between patients, the diagnosis of ASD can be quite difficult. Therefore, it is necessary to distinguish ASD from other neuropsychiatric disorders, and use appropriate evaluation methods to diagnose correctly in order to improve the clinical management of the disease (National Institute of Mental Health 2018; Baumer and Spence 2018).Recent studies have shown that multiple genetic factors play a role in the development of ASD (Lovato 2019). Siblings of ASD children also carry a higher risk of developing ASD (Bolton et al. 1994). It is reported that genetic and chromosomal abnormalities, such as Down's syndrome or fragile X syndrome, can be found in 10% of the children with ASD (DiGuiseppi et al. 2010; Hall et al. 2008). In addition, parental history of psychiatric disorders, premature birth and fetal exposure to psychotropic drugs, toxins, heavy metals and insecticides have been linked to the pathophysiology of ASD (Cattane et al. 2018; Sharma et al. 2018). With the emergence of possible etiologic causes, new therapy approaches may be introduced in the treatment of ASD (Emberti Gialloreti et al. 2019).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The role of pharmacists in the management of autism spectrum disorder: A survey to determine the knowledge and perception of the parents

Kara¹,

Cakir²,

Durman³

et al. 2019

Istanbul J Pharm

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“…In addition to the NICE guideline, nine systematic reviews , and 10 Cochrane reviews were relevant to impaired social communication as a treatment target in ASD.…”

Section: Results and Clinical Practice Recommendationsmentioning

confidence: 99%

Systematic review and guide to management of core and psychiatric symptoms in youth with autism

Ameis

Kassee

Corbett-Dick

et al. 2018

Acta Psychiatr Scand

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“…Thus, we included 17 systematic reviews. 4,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] Results from systematic reviews A summary of each systematic review is presented narratively below. In addition, Table 2 4,10-25 presents the issues addressed, the main findings from each systematic review and the quality of the evidence (based on the GRADE approach).…”

Section: Search Resultsmentioning

confidence: 99%

What do Cochrane systematic reviews say about interventions for autism spectrum disorders?

et al. 2017

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CONTEXT AND OBJECTIVE: Autism spectrum disorders (ASDs) include autistic disorder, Asperger's disorder and pervasive developmental disorder. The manifestations of ASDs can have an important impact on learning and social functioning that may persist during adulthood. The aim here was to summarize the evidence from Cochrane systematic reviews on interventions for ASDs. DESIGN AND SETTING: Review of systematic reviews, conducted within the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo. METHODS:We included and summarized the results from Cochrane systematic reviews on interventions for ASDs. RESULTS: Seventeen reviews were included. These found weak evidence of benefits from acupuncture, gluten and casein-free diets, early intensive behavioral interventions, music therapy, parent-mediated early interventions, social skill groups, Theory of Mind cognitive model, aripiprazole, risperidone, tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRI); this last only for adults. No benefits were found for sound therapies, chelating agents, hyperbaric oxygen therapy, omega-3, secretin, vitamin B6/ magnesium and SSRI for children. CONCLUSION: Acupuncture, gluten and casein-free diets, early intensive behavioral interventions, music therapy, parent-mediated early interventions, social skill groups and the Theory of Mind cognitive model seem to have benefits for patients with autism spectrum disorders (very low to low-quality evidence). Aripiprazole, risperidone, tricyclic antidepressants and SSRI (this last only for adults) also showed some benefits, although associated with higher risk of adverse events. Experimental studies to confirm a link between probable therapies and the disease, and then high-quality long-term clinical trials, are needed. RESUMO MÉTODOS:Nós incluímos e resumimos os resultados de revisões sistemáticas Cochrane sobre intervenções para TEA. RESULTADOS: Foram incluídas 17 revisões que encontraram evidências fracas de benefícios da acupuntura, dietas isentas de glúten e caseína, intervenção comportamental intensiva precoce, musicoterapia, intervenção precoce mediada pelos pais, grupos de habilidades sociais, modelo cognitivo de Teoria da Mente, aripiprazol, risperidona, antidepressivos tricíclicos, inibidores seletivos da recaptação da serotonina (ISRS); o último apenas para adultos. Nenhum benefício foi encontrado com terapias sonoras, agentes quelantes, oxigenoterapia hiperbárica, ômega-3, secretina, vitamina B6/magnésio e ISRS para crianças. CONCLUSÃO: Acupuntura, dietas sem glúten e caseína, intervenção comportamental intensiva precoce, musicoterapia, intervenção precoce mediada pelos pais, grupos de habilidades sociais e modelo cognitivo de Teoria da Mente parecem ter benefícios para pacientes com TEA (evidência de qualidade muito baixa a baixa). Aripiprazol, risperidona, antidepressivos tricíclicos e ISRS (o último apenas para adultos) também apresentam algum benefício, embora estejam associados a maior risco de event...

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Chelation for autism spectrum disorder (ASD)

Cited by 44 publications

References 52 publications

The role of pharmacists in the management of autism spectrum disorder: A survey to determine the knowledge and perception of the parents

The role of pharmacists in the management of autism spectrum disorder: A survey to determine the knowledge and perception of the parents

Systematic review and guide to management of core and psychiatric symptoms in youth with autism

What do Cochrane systematic reviews say about interventions for autism spectrum disorders?

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