Chelating, antioxidant and antiproliferative activity of Vicia sativa polyphenol extracts

Megı́as, Cristina; Pastor-Cavada, Elena; Torres‐Fuentes, Cristina; Girón‐Calle, Julio; Alaiz, Manuel; Juan, Rocío; Pastor, J.; Vioque, Javier

doi:10.1007/s00217-009-1178-x

Cited by 56 publications

(42 citation statements)

References 34 publications

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“…Thus, A. macrostachyum has compounds with Cu 2 + -chelating activity, possibly of a phenolic nature (Meg í as et al 2009 ), which could be used to counteract the onset and/or progression of AD. In fact, there is supporting evidence for a link between increases in the concentration of copper ions and ROS generation in AD patients and in neuronal cell death (Gaeta and Hider 2005 ).…”

Section: Resultsmentioning

confidence: 98%

The marine halophytes Carpobrotus edulis L. and Arthrocnemum macrostachyum L. are potential sources of nutritionally important PUFAs and metabolites with antioxidant, metal chelating and anticholinesterase inhibitory activities

et al. 2012

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We report antioxidant, metal chelating and anticholinesterase activities of methanol extracts from two edible halophytes, Carpobrotus edulis and Arthrocnemum macrostachyum. We also report a preliminary chemical screening, total contents of phenolic compounds in the extracts and the fatty acid profi les of both species. Arthrocnemum macrostachyum is a potential source of metabolites with free radical scavenging, iron (Fe 3 + ) reducing and copper (Cu 2 + ) chelating activities; it had a high concentration of polyunsaturated fatty acids (46.5 % ), mainly α -linolenic and linoleic acids. Carpobrotus edulis had dual anti-cholinesterase activity against both acetylcholinesterase and butyrylcholinesterase. Both species had a high content of phenolic compounds. Arthrocnemum macrostachyum is a potential biological source of biochemicals counteracting free radical-induced oxidative damage and also degenerative diseases associated with metabolic stress, such as cancer and neurological disorders. Carpobrotus edulis is a candidate species for future studies on novel and alternative therapies for the treatment of neurological disorders associated with low levels of acetylcholine in the brain.

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Section: Resultsmentioning

confidence: 98%

The marine halophytes Carpobrotus edulis L. and Arthrocnemum macrostachyum L. are potential sources of nutritionally important PUFAs and metabolites with antioxidant, metal chelating and anticholinesterase inhibitory activities

et al. 2012

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“…Copper (II) ion chelating activity was determined using a modified Megías method (33). Briefly, 30 μL of extract, 290 μL of 50 mM sodium acetate buffer (pH 6.0), 10 μL of copper sulfate (2 mg/mL), and 4 mM PV were loaded into a 96-well plate.…”

Section: Methodsmentioning

confidence: 99%

Influence of Roasting Treatment on the Antioxidant Activities and Color of Burdock Root Tea

Lee

Kim

2017

JFN

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The major trend in the antioxidant market is the growing consumer demand for natural antioxidants. Tea, one of the most widely consumed beverages in the world, is an easy way to obtain antioxidant components from a natural source. Our objective was to develop burdock root tea (BRT) with potent antioxidant activity and good color quality. In order to obtain maximum antioxidant activity and quality, the effect of roasting was determined. The antioxidant capacities and total phenolic contents of BRT increased as roasting increased. The color of BRT became darker with increased roasting, extraction time, and amount of burdock roots. Color of BRT was also positively correlated with total antioxidant capacity. Roasting significantly enhanced the total antioxidant activities and color quality of BRT. These results suggest that roasting BRT increases beneficial antioxidant components from burdock roots.

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“…Cupric reducing antioxidant capacity of Rheum extract was determined according to the method of Megías [25]. In each well of a 96-well plate, 30 μL hot water extract sample which final concentration was different from 0.25 to 5.0 mg/mL was mixed with 6 μL of 4 mM PV, 290 μL of 50 mM sodium acetate buffer (pH 6.0), and 10 μL of 2 mM copper sulfate.…”

Section: Determination Of Copper Chelating Activitymentioning

confidence: 99%

Lipid Peroxidation and Antioxidant Activities of the Aqueous Rhizome Extract of Rheum officinale Baillon

Chang

Kim

2018

Journal of Food Quality

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Generation of reactive oxygen species (ROS) is associated with dysregulation of antioxidant defense mechanisms and incidence of human diseases. e speci c aim of this study was to investigate the lipid oxidation and antioxidant activity of aqueous extract of Rheum o cinale Baillon rhizome in order to evaluate its potential as a future novel natural antioxidant resource and a functional ingredient in food and pharmaceutical formations. Total phenolic and avonoid contents of Rheum rhizome extract were dose dependently increased. Consistent with this, radical scavenging activities of Rheum rhizome extract as determined by 2,2-diphenyl-1-picrylhydrazyl assay and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging activity were signi cantly elevated as the concentration increased. In addition, the treatment of aqueous Rheum rhizome extract signi cantly increased ferric reducing and copper chelating activities. According to results of thiobarbituric acid reactive substance analysis, Rheum rhizome extract signi cantly delayed lipid oxidation. Preincubation with Rheum rhizome extract signi cantly inhibited tert-butyl hydroperoxide-(t-BHP-) induced ROS generation. Moreover, superoxide anion production was signi cantly lower in Rheum rhizome extract-treated RAW264.7 macrophage cells than t-BHP-incubated cells (p < 0.05). ese ndings suggest that Rheum o cinale Baillon rhizome extract has a potential as an excellent natural antioxidant agent.

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Chelating, antioxidant and antiproliferative activity of Vicia sativa polyphenol extracts

Cited by 56 publications

References 34 publications

The marine halophytes Carpobrotus edulis L. and Arthrocnemum macrostachyum L. are potential sources of nutritionally important PUFAs and metabolites with antioxidant, metal chelating and anticholinesterase inhibitory activities

The marine halophytes Carpobrotus edulis L. and Arthrocnemum macrostachyum L. are potential sources of nutritionally important PUFAs and metabolites with antioxidant, metal chelating and anticholinesterase inhibitory activities

Influence of Roasting Treatment on the Antioxidant Activities and Color of Burdock Root Tea

Lipid Peroxidation and Antioxidant Activities of the Aqueous Rhizome Extract of Rheum officinale Baillon

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