Chelating activity of (2E,2′E)-2,2′-(pyridine-2,6-diylbis(ethan-1-yl-1-ylidene)bis(N-ethylhydrazinecarbothioamide)

Ali, Mayada S.; Hasan, Mohamad K.

doi:10.1016/j.molstruc.2021.130436

Cited by 3 publications

(5 citation statements)

References 33 publications

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“…Previously, thiosemicarbazone ligand and metal-ligand complexes were synthesized and fully characterized at Kuwait University laboratory by x-ray crystallography, proton and carbon NMR, IR, molecular weight, molar conductivity, color, melting point, partial elemental analysis, XRD, electronic and magnetic measurements, DSC and TGA thermal analysis, and the bacteria and fungi activities (Ali & Hasan, 2021 ). In 2021, Ali et al.…”

Section: Discussionmentioning

confidence: 99%

“…proved that the ligand has an orthorhombic crystal system, and it is a chelating agent that acts as both neutral and dibasic pentadentate (N3S2); neutral and dibasic tetradentate (N2S2). On the other hand, metal-ligand complexes are potent chelating agents and exhibited octahedral (Ni-L complex), square planner (Pt-L and Pd-L complexes), and square-pyramid (VO-L, Mn-L, Cu-L, CuClO 4 -L, and CuAg-L complexes) geometrical arrangement (Ali & Hasan, 2021 ). It is important to mention that the transition metals increase the stability of the complexes (Abdellatif et al., 2016 ; Abdellatif, 2020 ; Ali & Hasan, 2021 ) and the positive metal ion toxicity to the living organism (Shaw, 1961 ; Paterson & Donnelly, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, metal-ligand complexes are potent chelating agents and exhibited octahedral (Ni-L complex), square planner (Pt-L and Pd-L complexes), and square-pyramid (VO-L, Mn-L, Cu-L, CuClO 4 -L, and CuAg-L complexes) geometrical arrangement (Ali & Hasan, 2021 ). It is important to mention that the transition metals increase the stability of the complexes (Abdellatif et al., 2016 ; Abdellatif, 2020 ; Ali & Hasan, 2021 ) and the positive metal ion toxicity to the living organism (Shaw, 1961 ; Paterson & Donnelly, 2011 ). Thiosemicarbazone is known for its strong NNS chelating agent, characterized by anticancer activity, and this activity increase when metals exist in the structure which has progressed to human clinical trials (Paterson & Donnelly, 2011 ; Shakya & Yadav, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…The zeta potential data showed that LDL particles diameter containing metal-ligand complexes were bigger than the LDL particles containing the ligand, which is also bigger than the plain LDL particles. This is due to the interactions and geometry of the central metal ion with the ligand which increase the stability of the complex (Ali & Hasan, 2021 ). Any drug delivery strategy starts with the agents’ stability both at 37 °C for treatment and at 4 °C for storage which proven previously (Alhadad et al., 2020 ; Alhadad, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Anticancer agents were synthesized previously in our laboratory at Kuwait University, chemically and physically characterized at the research sector project unit (RSPU) laboratories (Ali & Hasan, 2021 ). All the chemical reagents are commercially available with the analytical grades and ready for direct use without preparation from Merck and Sigma Aldrich.…”

Section: Methodsmentioning

confidence: 99%

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Low-density lipoprotein encapsulated thiosemicarbazone metal complexes is active targeting vehicle for breast, lung, and prostate cancers

et al. 2022

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Cancer is a leading cause of death worldwide and affects society in terms of the number of lives lost. Current cancer treatments are based on conventional chemotherapy which is nonspecific in targeting cancer. Therefore, intensive efforts are underway to better target cancer-specific cells while minimizing the side effects on healthy tissues by using LDL particles as active drug delivery vehicles. The goal is to encapsulate anticancer agents thiosemicarbazone metal-ligand complexes into LDL particles to increase the cytotoxic effect of the agent by internalization through LDL receptors into MCF7, A549, and C42 cancer cell lines as segregate models for biological evaluations targeting tubulin. Zeta potential data of LDL-particles encapsulated anticancer agents showed an acceptable diameter range between 66–91 nm and uniform particle morphology. The results showed cell proliferation reduction in all tested cell lines. The IC 50 values of LDL encapsulated thiosemicarbazone metal-ligand complexes treated with MCF7, A549, and C42 ranged between 1.18–6.61 µM, 1.17–9.66 µM, and 1.01–6.62 µM, respectively. Western blot analysis showed a potent decrease in tubulin expression when the cell lines were treated with LDL particles encapsulated with thiosemicarbazone metal-ligand complexes as anticancer agents. In conclusion, the data provide strong evidence that LDL particles are used as an active drug delivery strategy for cancer therapy.

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Section: Discussionmentioning

confidence: 99%