Checkpoints in the development of thymic cortical epithelial cells

Shakib, Saba; Desanti, Guillaume E.; Jenkinson, William E.; Parnell, Sonia M.; Jenkinson, Eric J.; Anderson, Graham

doi:10.4049/jimmunol.0990018

Cited by 12 publications

(4 citation statements)

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“…3 H), suggesting that there is no preferential ex pansion of either cTECs or mTECs in Rb family mutant mice. We also measured by flow cytometry the proportions of cTEC precursors as identified by CD40 and CD205 ex pression (Shakib et al, 2009;Nowell et al, 2011). There was with the thymi from chimeric wildtype/control mice (Fig.…”

Section: Br Ief Definitive Repor Tmentioning

confidence: 99%

Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression

Garfin

Min

Bryson

et al. 2013

Journal of Experimental Medicine

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Section: Br Ief Definitive Repor Tmentioning

confidence: 99%

Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression

Garfin

Min

Bryson

et al. 2013

Journal of Experimental Medicine

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“…On the other hand, as for the mTEC lineage, the expression of MHCII molecules defines the maturation of cTECs (Shakib et al 2009 ). In WT thymi, the proportions of both MHCII lo (Fig.…”

Section: Resultsmentioning

confidence: 99%

Delayed maturation of thymic epithelium in mice with specific deletion of β-catenin gene in FoxN1 positive cells

Montero-Herradón

Zapata

2021

Histochem Cell Biol

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Wnt signalling pathways have been reported to be involved in thymus development but their precise role in the development of both thymic epithelium (TE) and thymocytes is controversial. Herein, we examined embryonic, postnatal and adult thymi of mice with a specific deletion of β-catenin gene in FoxN1+ thymic epithelial cells (TECs). Together with a high postnatal mouse mortality, the analysis showed severe thymic hypocellularity, largely due an important reduction in numbers of developing thymocytes, and delayed, partially blocked maturation of mutant TECs. Affected TECs included largely cortical (c) TEC subsets, such as immature MTS20+ TECs, Ly51+ cTECs and a remarkable, rare Ly51+MTS20+MHCIIhi cell subpopulation previously reported to contain thymic epithelial progenitor cells (TEPCs) (Ulyanchenko et al., Cell Rep 14:2819–2832, 2016). In addition, altered postnatal organization of mutant thymic medulla failed to organize a unique, central epithelial area. This delayed maturation of TE cell components correlated with low transcript production of some molecules reported to be masters for TEC maturation, such as EphB2, EphB3 and RANK. Changes in the thymic lymphoid component became particularly evident after birth, when molecules expressed by TECs and involved in early T-cell maturation, such as CCL25, CXCL12 and Dll4, exhibited minimal values. This represented a partial blockade of the progression of DN to DP cells and reduced proportions of this last thymocyte subset. At 1 month, in correlation with a significant increase in transcript production, the DP cell percentage increased in correlation with a significant fall in the number of mature TCRαβhi thymocytes and peripheral T lymphocytes.

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“…During embryonic development, the cell surface markers CD40 and CD205 can be used to map TEC development. CD40 low CD205 low progenitor cells gain cell surface CD40 and CD205 expression, resulting in transitional progenitors which have the potential to differentiate into the two mature populations: cTEC (CD40 int CD205 high Ly51+) and mTEC (CD40 high CD205 low UEA-1+) [9,10].…”

Section: Hedgehog Signalling In Foetal Thymic Epithelial Cell (Tec) Dmentioning

confidence: 99%

“…The development of TEC in the embryonic thymus is less well understood, but both lineages of TEC originate from a common CD45–Epcam-1+CD40 low CD205 low progenitor cell population [7,8]. As development proceeds, these cells gain greater intensity of CD40 and CD205 expression, resulting in transitional progenitors which have the potential to differentiate into two populations—cTEC (CD40 int CD205 high Ly51+) or mTEC (CD40 high CD205 low UEA-1+) [9,10].…”

Section: Introductionmentioning

confidence: 99%

Hedgehog Signalling in the Embryonic Mouse Thymus

Lau¹,

Mengrelis²,

Ross³

et al. 2016

JDB

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T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte–TEC cross-talk in the embryonic mouse thymus during the last week of gestation.

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Checkpoints in the development of thymic cortical epithelial cells

Abstract: In Fig. 5, the cell "Imm. cTec," labeled "EpCAM1 ϩ CD40 ϩ CD205 ϩ MHC-II Ϫ ," should be labeled "EpCAM1 ϩ CD40 Ϫ CD205 ϩ MHC-II Ϫ ." The corrected figure is shown below. The published legend is correct but is shown again here for reference.

Cited by 12 publications

References 0 publications

Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression

Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression

Delayed maturation of thymic epithelium in mice with specific deletion of β-catenin gene in FoxN1 positive cells

Hedgehog Signalling in the Embryonic Mouse Thymus

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