Check of Antiviral Activity of Nanocomposites with Active Check of Antiviral Activity of Drugs Based on Nanocomposites, Which Contained Oligonucleotides for Direct Splitting Viral Genome of Influenza Virus Type A

Pletnev, Dmitriy; Evdokimov, Alexey A.; Belanov, E. F.; Malygin, E. G.; Balachnin, Sergey; Серова, О. А.; Zinoviev, Viktor; Зарытова, В. Ф.; Левина, А. С.; Репкова, М. Н.; Исмагилов, З. Р.; Shikina, N. V.; Загребельный, С Н; Байбородин, С. И.

doi:10.1016/j.antiviral.2008.01.092

Cited by 4 publications

(2 citation statements)

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“…The selected nanoparticles are biocompatible and non-toxic and enable the ODN delivery via the cell membrane [ 105 , 106 ]. Moreover, they stabilize and protect the ODN against intracellular enzymes [ 107 ]. Upon entry into cells, the carried oligonucleotides are released from the nanocomposites in the cytoplasm or penetrate into the nuclei and bind to the RNA molecules [ 108 ].…”

Section: Biomedical Applications Of Antiviral Nanomaterialsmentioning

confidence: 99%

Biomedical Applications of Antiviral Nanohybrid Materials Relating to the COVID-19 Pandemic and Other Viral Crises

2021

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The COVID-19 pandemic has driven a global research to uncover novel, effective therapeutical and diagnosis approaches. In addition, control of spread of infection has been targeted through development of preventive tools and measures. In this regard, nanomaterials, particularly, those combining two or even several constituting materials possessing dissimilar physicochemical (or even biological) properties, i.e., nanohybrid materials play a significant role. Nanoparticulate nanohybrids have gained a widespread reputation for prevention of viral crises, thanks to their promising antimicrobial properties as well as their potential to act as a carrier for vaccines. On the other hand, they can perform well as a photo-driven killer for viruses when they release reactive oxygen species (ROS) or photothermally damage the virus membrane. The nanofibers can also play a crucial protective role when integrated into face masks and personal protective equipment, particularly as hybridized with antiviral nanoparticles. In this draft, we review the antiviral nanohybrids that could potentially be applied to control, diagnose, and treat the consequences of COVID-19 pandemic. Considering the short age of this health problem, trivially the relevant technologies are not that many and are handful. Therefore, still progressing, older technologies with antiviral potential are also included and discussed. To conclude, nanohybrid nanomaterials with their high engineering potential and ability to inactivate pathogens including viruses will contribute decisively to the future of nanomedicine tackling the current and future pandemics.

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Section: Biomedical Applications Of Antiviral Nanomaterialsmentioning

confidence: 99%

Biomedical Applications of Antiviral Nanohybrid Materials Relating to the COVID-19 Pandemic and Other Viral Crises

2021

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“…Помимо этого, дизайн нанокомпозита может быть подобран таким образом, чтобы осуществлять адресную доставку фармакологических агентов и улучшить фармакокинетику. Важное преимущество наночастиц по сравнению с другими транспортерами олигонуклеотидов -их способность защищать олигонуклеотиды от действия клеточных нуклеаз (Rosi et al, 2006;Pletnev et al, 2008).…”

Section: преимущества и проблемы использования олигонуклеотидов в качunclassified

Antisense oligonucleotides for the arterial hypertension mechanisms study and therapy

et al. 2018

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Arterial hypertension is one of the most common chronic diseases in adults all over the world. This pathology can not only reduce patients’ life quality, but can also be accompanied by a number of complications. Despite the fact that there is a large group of antihypertensive drugs on the market, mainly representing different combinations of inhibitors of the renin-angiotensin system, adrenoreceptor blockers in combination with diuretics, there is no generally accepted “gold standard” for drugs that would not have side effects. The review discusses the main aspects of antisense oligonucleotides use in the context of arterial hypertension. It is well known that the medical implementation of antisense oligonucleotides aims to block the expression of particular genes involved in the pathology development, and a key advantage of this technique is a high selectivity of the effect. However, with the undoubted advantages of the method, there are difficulties in its application, related both to the properties of the oligonucleotides themselves (insufficient stability and poor penetration into cells), and to the variety of mechanisms of the origin of a particular pathology, arterial hypertension, in our case. The review provides a brief description of the main molecular targets for antisense treatment of hypertensive disease. The newest targets for therapy with oligonucleotides – microRNAs – are discussed. The main modifications of antisense nucleotides, designed to increase the duration of their effects and simplify the delivery of this type of drugs to the targets are discussed, in particular, combining antisense oligonucleotides with adenovirus-based expression vectors. Particular attention is given to antisense oligonucleotides in the complex with nanoparticles. The review discusses the results of the use of titanium dioxide (TiO2) containing antisense nanocomposites for the angiotensin converting enzyme in rats with stress induced arterial hypertension (ISIAH). It was shown that the use of antisense oligonucleotides continues to be a promising technique for studying the mechanisms of various forms of hypertensive disease and has a high potential for therapeutic use.

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Pronounced therapeutic potential of oligonucleotides fixed on inorganic nanoparticles against highly pathogenic H5N1 influenza A virus in vivo

Левина

Репкова

Shikina

et al. 2021

European Journal of Pharmaceutics and Biopharmaceutics

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Check of Antiviral Activity of Nanocomposites with Active Check of Antiviral Activity of Drugs Based on Nanocomposites, Which Contained Oligonucleotides for Direct Splitting Viral Genome of Influenza Virus Type A

Cited by 4 publications

References 0 publications

Biomedical Applications of Antiviral Nanohybrid Materials Relating to the COVID-19 Pandemic and Other Viral Crises

Biomedical Applications of Antiviral Nanohybrid Materials Relating to the COVID-19 Pandemic and Other Viral Crises

Antisense oligonucleotides for the arterial hypertension mechanisms study and therapy

Pronounced therapeutic potential of oligonucleotides fixed on inorganic nanoparticles against highly pathogenic H5N1 influenza A virus in vivo

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