CHD1L is a novel independent prognostic factor for gastric cancer

Su, Zhi; Zhao, Juanjuan; Xian, Guozhe; Geng, Wei; Rong, Zhonghou; Wu, Yuangang; Qin, Chengyong

doi:10.1007/s12094-013-1136-8

Cited by 24 publications

(19 citation statements)

References 12 publications

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“…Moreover, the frequency of CHDIL overexpression increased with an ascending pN status and advancing clinical stage in NSCLC, especially in lung ADCs. Similar results were also observed in other types of human cancer [ 6 , 8 , 9 ]. In HCC, overexpression of CHD1L was associated closely with microsatellite formation and venous invasion [ 6 ].…”

Section: Discussionsupporting

confidence: 88%

“…In HCC, overexpression of CHD1L was associated closely with microsatellite formation and venous invasion [ 6 ]. In gastric cancer, up-regulated expression of CHD1L was reported to be correlated with tumor depth, nodal involvement and distant metastasis [ 9 ]. While in breast cancer, presence of CHD1L expression was associated with higher Ki-67 index and HER2 amplification [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…1 ). For the evaluation of CHD1L staining, a semi-quantitative scoring criterion was used, in which both staining intensity and positive cells percentage were recorded [ 9 , 12 ]. A staining index (with values from 0 to 12) was obtained as the intensity of CHDIL staining (0 = negative, 1 = weakly positive, 2 = moderate positive, 3 = strongly positive) times the proportion of immunopositive tumor cells (0% = 0, <10% = 1, 10% to <50% = 2, 50% to <75% = 3, ≥75% = 4).…”

Section: Methodsmentioning

confidence: 99%

“…A series of our further studies demonstrated that CHD1L contributes to HCC cell migration, invasion and metastasis, and is positively associated with tumor progression in HCC patients [ 5 – 7 ]. Recently, CHD1L has also been reported as a novel biomarker for patients' prognosis in several types of solid tumor, including breast cancer [ 8 ], gastric cancer [ 9 ], colorectal cancer [ 10 ], bladder cancer [ 11 ] and ovarian cancer [ 12 ]. To date, however, the abnormalities of CHD1L and its oncogenic role in NSCLC have not been studied.…”

Section: Introductionmentioning

confidence: 99%

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Overexpression of CHD1L is positively associated with metastasis of lung adenocarcinoma and predicts patients poor survival

Fang

Chen³

et al. 2015

Oncotarget

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CHD1L (chromodomain helicase/ATPase DNA binding protein 1-like gene) has been demonstrated as an oncogene in hepatocellular carcinoma (HCC), however, the role of CHD1L in non-small-cell lung cancer (NSCLC) tumorigenesis hasn't been elucidated. In this study, the expression and amplification status of CHD1L were examined by immunohistochemistry and fluorescence in situ hybridization respectively in 248 surgically resected NSCLCs. The associations between CHD1L expression and clinicopathologic features and the prognostic value of CHD1L were analyzed. Overexpression and amplification of CHD1L was found in 42.1% and 17.7% of NSCLCs, respectively. The frequency of CHD1L overexpression (53.2% vs. 28.1%, P = 0.002) and amplification (25.2% vs. 8.2%, P = 0.020) in adenocarcinoma (ADC), was much higher than that in squamous cell carcinoma (SCC). CHD1L overexpression was associated closely with ascending pN status (P < 0.001), advanced clinical stage (P = 0.001) and tumor distant metastasis (P = 0.001) in ADCs, but not in SCCs. For the whole cohort and ADC patients, univariate survival analysis demonstrated a significant association of CHD1L overexpression with shortened survival; and in multivariate analysis, CHD1L overexpression was evaluated as a independent predictor for overall survival and distant metastasis free survival. These results suggested that overexpression of CHD1L is positively associated with tumor metastasis of lung ADC, and might serve as a novel prognostic biomarker and potential therapeutic target for lung ADC patients.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Overexpression of CHD1L is positively associated with metastasis of lung adenocarcinoma and predicts patients poor survival

Fang

Chen³

et al. 2015

Oncotarget

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“…The chromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L gene) was originally isolated from hepatocellular carcinoma tissue and identified as an oncogene in our previous study (9). A functional study using CHD1L transgenic mice has confirmed its role in tumorigenesis (10), and epidemiological studies have suggested that CHD1L is either associated with cancer-inducing processes or can be used as a predictive biomarker for hepatocellular carcinoma (11)(12)(13) and several other cancers, such as ovarian carcinoma (14), bladder cancer (15), colorectal carcinoma (16), breast cancer (17), lung adenocarcinoma (18), glioma (19), and gastric cancer (20). CHD1L has also been defined as an ATP-dependent chromatin-remodeling enzyme that plays an important role in preserving chromosome integrity and promoting DNA repair (21).…”

mentioning

confidence: 53%

A Novel Regulatory Axis, CHD1L-MicroRNA 486-Matrix Metalloproteinase 2, Controls Spermatogonial Stem Cell Properties

Liu

Maguire

Bai

et al. 2019

Molecular and Cellular Biology

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Spermatogonial stem cells (SSCs) are unipotent germ cells that are at the foundation of spermatogenesis and male fertility. However, the underlying molecular mechanisms governing SSC stemness and growth properties remain elusive. We have recently identified chromodomain helicase/ATPase DNA binding protein 1-like (Chd1l) as a novel regulator for SSC survival and self-renewal, but how these functions are controlled by Chd1l remains to be resolved. Here, we applied high-throughput small RNA sequencing to uncover the microRNA (miRNA) expression profiles controlled by Chd1l and showed that the expression levels of 124 miRNA transcripts were differentially regulated by Chd1l in SSCs. KEGG pathway analysis shows that the miRNAs that are differentially expressed upon Chd1l repression are significantly enriched in the pathways associated with stem cell pluripotency and proliferation. As a proof of concept, we demonstrate that one of the most highly upregulated miRNAs, miR-486, controls SSC stemness gene expression and growth properties. The matrix metalloproteinase 2 (MMP2) gene has been identified as a novel miR-486 target gene in the context of SSC stemness gene regulation and growth properties. Data from cotransfection experiments showed that Chd1l, miR-486, and MMP2 work in concert in regulating SSC stemness gene expression and growth properties. Finally, our data also revealed that MMP2 regulates SSC stemness gene expression and growth properties through activating β-catenin signaling by cleaving N-cadherin and increasing β-catenin nuclear translocation. Our data demonstrate that Chd1l–miR-486–MMP2 is a novel regulatory axis governing SSC stemness gene expression and growth properties, offering a novel therapeutic opportunity for treating male infertility.

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CHD1L Expression Increases Tumor Progression and Acts as a Predictive Biomarker for Poor Prognosis in Pancreatic Cancer

Liu

Zhong

et al. 2017

Dig Dis Sci

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CHD1L is a novel independent prognostic factor for gastric cancer

Abstract: These results indicated that CHD1L could serve as a prognostic marker for GC.

Cited by 24 publications

References 12 publications

Overexpression of CHD1L is positively associated with metastasis of lung adenocarcinoma and predicts patients poor survival

Overexpression of CHD1L is positively associated with metastasis of lung adenocarcinoma and predicts patients poor survival

A Novel Regulatory Axis, CHD1L-MicroRNA 486-Matrix Metalloproteinase 2, Controls Spermatogonial Stem Cell Properties

CHD1L Expression Increases Tumor Progression and Acts as a Predictive Biomarker for Poor Prognosis in Pancreatic Cancer

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