Chavibetol corrects thyrotoxicosis through alterations in thyroid peroxidase

Panda, Sasmita; Sharma, Rajesh; Kar, Anand

doi:10.1007/s00210-018-01606-x

Cited by 11 publications

(4 citation statements)

References 37 publications

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“…In the current study, induction of hyperthyroidism in rats was effectively achieved, as indicated by the marked elevation in serum levels of tT3 and tT4 in hyperthyroid rats compared to controls. These observations are consistent with previous findings (Panda et al, 2019;Ghosh et al, 2022). The coadministration of melatonin to hyperthyroid rats resulted in an interesting decrease in thyroid hormone levels, suggesting a potential suppression of thyroid hormone synthesis and/or release at the glandular level.…”

Section: Discussionsupporting

confidence: 93%

“…The histopathological changes induced by hyperthyroidism in the thyroid glands revealed various degenerative alterations marked by deteriorated thyroid follicles with desquamated epithelium and scanty colloid quantities. These results are consistent with the findings reported by Panda et al (2019). Melatonin coadministration to hyperthyroid rats significantly improved the architecture of the thyroid tissue, as shown by the presence of the majority of thyroid follicles with a regular structure and homogenous colloids.…”

Section: Discussionsupporting

confidence: 93%

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Cellular Changes in the Thymus Gland induced by Hyperthyroidism and Melatonin Administration

Habk,

Azab,

Ismail

et al. 2023

Benha Veterinary Medical Journal

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The current research aimed to evaluate the effects of L-thyroxine-induced hyperthyroidism and melatonin administration on the histopathology of the thyroid and thymus glands and Bax immunoreactivity. The rats were divided into four groups, comprising ten rats each. Rats were given the following treatments for four weeks: Group I served as the control group; Group II received melatonin; Group III received L-thyroxine; and Group IV received both L-thyroxine and melatonin. The serum levels of total T3 (tT3) and total T4 (tT4) were assessed, as well as histological examinations of the thyroid and thymus and analysis of Bax immunoexpression in both organs. The obtained results showed that in rats with hyperthyroidism, melatonin administration caused a noticeably lower level of thyroid hormones. According to the histopathological examination, hyperthyroidism induced various deteriorating changes in the thyroid and thymus glands, while melatonin therapy reduced these adverse effects. The immunohistochemical analysis demonstrated that hyperthyroid rats displayed a substantial elevation in Bax expression in the thyroid and thymus glands. However, melatonin treatment in hyperthyroid rats resulted in a marked reduction in Bax expression. Thus, it could be concluded that hyperthyroidism induced a range of degenerative changes and markedly elevated Bax expression in thyroid and thymus tissues. However, melatonin intervention ameliorated these negative effects.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Cellular Changes in the Thymus Gland induced by Hyperthyroidism and Melatonin Administration

Habk,

Azab,

Ismail

et al. 2023

Benha Veterinary Medical Journal

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“…As carried out earlier 61 , individual protein samples (20 μg each) extracted from thyroid gland were separated on a 12% SDS-polyacrylamide gel and then transferred on to a nitrocellulose membrane electrophoretically. The membrane was blocked in a 5% BSA and 0.5% Tween-20 for 1 h with mild shaking at room temperature followed by an overnight incubation at 4 °C with the primary antibodies, anti-TPO (1:2000 dilutions), anti-TSHR (1:2000 dilutions) and internal loading control β-actin (1:2000 dilutions) overnight at 4 °C.…”

Section: Methodsmentioning

confidence: 99%

Allylpyrocatechol, isolated from betel leaf ameliorates thyrotoxicosis in rats by altering thyroid peroxidase and thyrotropin receptors

Panda

Sikdar

Biswas

et al. 2019

Sci Rep

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Allylpyrocatechol (APC) was isolated from betel leaf and its possible role in L-thyroxin (L-T 4 )-induced thyrotoxic rats was evaluated. The disease condition, thyrotoxicosis was confirmed by higher levels of thyroid hormones and low thyrotropin (TSH) in serum. Increased hepatic activities of 5′-mono-deiodinase(5′D1), glucose-6-phospatase (G-6-Pase); serum concentrations of alanine transaminase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase(LDH) and tumour necrosis factor-alpha(TNF-α) were observed in thyrotoxic rats. Hepatic lipid peroxidation(LPO) was also increased and the endogenous antioxidants were depleted in these rats. In western blot analysis thyroid peroxidase expression was found to be reduced, whereas thyrotropin receptor(TSHR) expression was enhanced in thyroid gland of these animals. On the other hand, APC treatment in thyrotoxic rats decreased the levels of serum thyroid hormones, ALT, AST, TNF-α and LDH, as well as hepatic 5′ D1 and G-6-Pase activities. However, it increased the serum TSH levels. APC also reduced the hepatic LPO and increased the cellular antioxidants in thyrotoxic rats. However, expression of TSHR was inhibited and TPO was increased by APC. The test compound also improved histological features in both liver and thyroid. Present report appears to be the first one that indicates the positive role of APC in ameliorating T 4 -induced thyrotoxicosis.

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“…Those identified compounds with >70% of similarity based on mass spectral library are listed in Table 1. According to previous studies [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37], 8 identified compounds in HWE and 9 compounds in HEE have been reported to exhibit antidiabetic, anti-inflammatory, or antioxidant properties based on in vitro and in vivo models. Among these compounds, vanillin, apocynin, methyl palmitate, and syringaldehyde have received considerable attention for their multiple pharmacological properties.…”

Section: Compound Identification In Hemp Root Extracts By Gas Chromat...mentioning

confidence: 99%

Protective Effects of Hemp (Cannabis sativa) Root Extracts against Insulin-Deficient Diabetes Mellitus In Mice

Kim

Kim³

et al. 2023

Molecules

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The pharmacological potential of industrial hemp (Cannabis sativa) has been widely studied. However, the majority of studies have focused on cannabidiol, isolated from the inflorescence and leaf of the plant. In the present study, we evaluated the anti-diabetic potential of hemp root water (HWE) and ethanol extracts (HEE) in streptozotocin (STZ)-induced insulin-deficient diabetic mice. The administration of HWE and HEE ameliorated hyperglycemia and improved glucose homeostasis and islet function in STZ-treated mice (p < 0.05). HWE and HEE suppressed β-cell apoptosis and cytokine-induced inflammatory signaling in the pancreas (p < 0.05). Moreover, HWE and HEE normalized insulin-signaling defects in skeletal muscles and apoptotic response in the liver and kidney induced by STZ (p < 0.05). Gas chromatography-mass spectrometry analysis of HWE and HEE showed possible active compounds which might be responsible for the observed anti-diabetic potential. These findings indicate the possible mechanisms by which hemp root extracts protect mice against insulin-deficient diabetes, and support the need for further studies geared towards the application of hemp root as a novel bioactive material.

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Chavibetol corrects thyrotoxicosis through alterations in thyroid peroxidase

Cited by 11 publications

References 37 publications

Cellular Changes in the Thymus Gland induced by Hyperthyroidism and Melatonin Administration

Cellular Changes in the Thymus Gland induced by Hyperthyroidism and Melatonin Administration

Allylpyrocatechol, isolated from betel leaf ameliorates thyrotoxicosis in rats by altering thyroid peroxidase and thyrotropin receptors

Protective Effects of Hemp (Cannabis sativa) Root Extracts against Insulin-Deficient Diabetes Mellitus In Mice

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