Chasing the treasures of the sea — bacterial marine natural products

Gulder, Tobias A. M.; Moore, Bradley S.

doi:10.1016/j.mib.2009.05.002

Cited by 120 publications

(86 citation statements)

References 58 publications

(98 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In another study, Fenical et al have reported that marine actinomycete is a rich source of salinosporamide A [32], which is a potential irreversible inhibitor of 20S proteasome and can act as an anticancer agent. In general, a number of active molecules derived from marine organisms is currently under laboratory investigation and clinical trials for drug development [33].…”

Section: Red Sea Microbial Diversity For Anticancer and Antimicrobialmentioning

confidence: 99%

Red Sea Microbial Diversity for Antimicrobial and Anticancer Agents

M¹

2016

J Mol Biomark Diagn

View full text Add to dashboard Cite

Marine natural products are valuable sources that could produce potential chemotherapeutic agents, and marinederived organisms are widely recognized as important sources of these natural products with interesting biological activities. Furthermore, Red sea was recognized as a rich source of microbial diversity with unique metabolites that can be of pharmaceutical and medicinal importance. The discovery of novel active metabolites provides an intellectual challenge to examine new products for medicinal purposes. Although many bacterial strains were isolated from Red sea with potent bioactivities; however, the microbial diversity of marine environment such Red sea remained largely un-explored. Lately, it has been possible to easily collect marine samples, isolate, and further identify diverse marine organisms (e.g. bacteria, fungi, and algae and marine invertebrate) by modern molecular techniques. Based on a wide range of screening and extraction methods, a vast number of metabolites have been extracted from marine sources with potential biological activities such as antibacterial, anticancer, anti-inflammatory agents and many others. In this article, we have reviewed the previous studies that have been conducted to explore marine-derived bioactives of Red sea. In addition, we have illustrated the following aspects: (i) Red sea microbial diversity for antibacterial and anticancer agents; (ii) the conventional and molecular approach used for screening and characterization marine microorganisms; (iii) characterization of natural products of microbial origin, and (iv) drug development from novel marine-derived metabolites and clinical trials. Moreover, modern molecular technologies, meta-genomic, proteomic and bio-chemo-informatics approaches are adding more potency to the targeted search of bioactive compounds derived from marine microbes. The novel marine derived drug discovery is aimed to improve our understanding of natural resources, to improve public health awareness about the environmental microbial diversity and their importance for nutraceuticals, pharmaceutical, agrochemicals and food processing. Recently, the research area of microbial diversity of the Red sea and their metabolites has opened a new access for significant sources of more effective drug entities with low coast.extreme conditions such as high temperature, pressure, and salinity. The experimental results suggested that these bacterial and archaeal communities are rich sources of active enzymes and metabolites, which can be applied for pharmaceutical and biotechnology-based applications [9].In previous studies, a number of bio-active compounds have been reported from marine sources with different degrees of action and potential, such as antibacterial, anticancer, antitumor, antiproliferative, anti-microtubule, cytotoxic, photoprotective, and antifouling properties [10][11][12]. Marine-derived metabolites, like peptides (ribosomal and non-ribosomal), alkaloids, polyketides and terpenes, have demonstrated antimicrobial and antiviral activ...

show abstract

Section: Red Sea Microbial Diversity For Anticancer and Antimicrobialmentioning

confidence: 99%

Red Sea Microbial Diversity for Antimicrobial and Anticancer Agents

M¹

2016

J Mol Biomark Diagn

View full text Add to dashboard Cite

show abstract

“…The cytotoxic properties of many secondary metabolites from marine organisms and bacteria are of particular interest for the development of new anticancer treatments [58]. For infectious diseases, natural products are effective because most of these compounds evolved from microbial warfare and show activity against other microorganisms at low concentrations [25,26,29].…”

Section: Developmentmentioning

confidence: 99%

“…The fact that marine invertebrates contain astounding levels of microbial diversity and form highly complex microbial communities led to the assumption, followed by confirmation in recent examples, that microbial symbionts like bacteria are important producers of natural products derived from marine species [58]. In particular, these include polyketides and nonribosomally synthesized peptides as well as unique biosynthetic enzymes which emerged as potent biocatalysts in medicinal chemistry [58,97].…”

Section: Marine Lifementioning

confidence: 99%

See 1 more Smart Citation

Discovery, Development, and Regulation of Natural Products

Krause¹,

Tobin²

2013

Using Old Solutions to New Problems - Natural Drug Discovery in the 21st Century

View full text Add to dashboard Cite

“…Comparison of the genomes of these marine sediment-derived strains with those of terrestrial origin will provide insight into the environmental adaptation and evolution of Streptomyces species. The genome mining of S. xinghaiensis will further explore the chemical diversity and genetic diversity of this species for discovery of novel compounds and enzymes for biotechnology applications (1,3).…”

Section: Streptomyces Xinghaiensis Nrrl B24674mentioning

confidence: 99%