Based on fieldwork and ethnographic interviews, this article explores the subjective meanings and processes of injecting methamphetamine and risk taking among 38 participants involved in a street drug scene, including long-term methamphetamine users and dealers recruited in an inner-city Los Angeles neighborhood, as a means of gaining insight into the factors facilitating injection. There were a multitude of individual, structural, social, and spatial factors that may influence injection as a mode of methamphetamine administration, including economic conditions, perceived cost, and efficiency of specific routes of use; social role and collective identification with a street scene; physical and social settings; drug policy and fear of arrest; social network factors, including the influence of sexual partners, peers, and the normalization of injection; other drug use, including individual drug histories and preferences for specific routes of administration among particular drug users (e.g., black tar heroin); and characteristics of the local drug market.