Chasing Methuselah: adult inducible GHRKO mice

Kopchick, John J.; Berryman, Darlene E.; List, Edward O.

doi:10.18632/aging.204016

Cited by 1 publication

(1 citation statement)

References 7 publications

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“…The existence of an early-life time window that determines the rate of aging [1][2][3] is supported by previous studies in growth hormone (GH)-deficient mice (Figure 1). GH receptor (GHR) knockout mice and GH-deficient dwarf mice live 40-50% longer than normal mice [44,45]. Developmental growth of these mice is inhibited, aging is slowed down and the development of age-related diseases is postponed.…”

Section: Growth Inhibition Decelerates Aging In Growth Hormone-defici...mentioning

confidence: 99%

Rapamycin treatment early in life reprograms aging: hyperfunction theory and clinical practice

Blagosklonny

2022

Aging

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Making provocative headlines, three outstanding publications demonstrated that early-life treatment with rapamycin, including treatments during developmental growth, extends lifespan in animals, confirming predictions of hyperfunction theory, which views aging as a quasi-program (an unintended continuation of developmental growth) driven in part by mTOR. Despite their high theoretical importance, clinical applications of two of these studies in mice, Drosophila and Daphnia cannot be implemented in humans because that would require growth retardation started at birth. A third study demonstrated that a transient (around 20% of total lifespan in Drosophila) treatment with rapamycin early in Drosophila adult life is as effective as lifelong treatment, whereas a late-life treatment is not effective. However, previous studies in mice demonstrated that a transient late-life treatment is highly effective. Based on hyperfunction theory, this article attempts to reconcile conflicting results and suggests the optimal treatment strategy to extend human lifespan.

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Section: Growth Inhibition Decelerates Aging In Growth Hormone-defici...mentioning

confidence: 99%

Rapamycin treatment early in life reprograms aging: hyperfunction theory and clinical practice

Blagosklonny

2022

Aging

View full text Add to dashboard Cite

show abstract

Chasing Methuselah: adult inducible GHRKO mice

Cited by 1 publication

References 7 publications

Rapamycin treatment early in life reprograms aging: hyperfunction theory and clinical practice

Rapamycin treatment early in life reprograms aging: hyperfunction theory and clinical practice

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