Charting the Next Road Map for CSF Biomarkers in Alzheimer's Disease and Related Dementias

Hu, William T.; Nayyar, Ashima; Kaluzová, Milota

doi:10.1007/s13311-023-01370-8

Cited by 3 publications

(1 citation statement)

References 212 publications

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“…These comorbidities include but are not limited to diabetes, cardiovascular disease, depression, and neuroinflammation (Santiago and Potashkin, 2021 ). In recent years, researchers have focused on investigating these comorbidities of AD to understand the disease progression better (Katabathula et al, 2023 ), identify potential new treatment approaches (Nitzan et al, 2021 ), and develop early biomarkers (Hu et al, 2023 ). In this Research Topic, we have delved into the different related symptoms of AD, aiming to enhance our understanding of disease etiologies and identify novel therapeutic approaches.…”

Section: Introductionmentioning

confidence: 99%

Editorial: Alzheimer-related affective symptoms – mechanism and treatment

Nitzan,

Frenkel,

Parker

et al. 2023

Front. Aging Neurosci.

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Section: Introductionmentioning

confidence: 99%

Editorial: Alzheimer-related affective symptoms – mechanism and treatment

Nitzan,

Frenkel,

Parker

et al. 2023

Front. Aging Neurosci.

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Lessons Learned in Time—Is Neurodegeneration Still Something Unpredictable?

2023

Neurotherapeutics

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Circulating microRNA miR-425-5p Associated with Brain White Matter Lesions and Inflammatory Processes

Van der Auwera,

Ameling,

Wittfeld

et al. 2024

IJMS

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White matter lesions (WML) emerge as a consequence of vascular injuries in the brain. While they are commonly observed in aging, associations have been established with neurodegenerative and neurological disorders such as dementia or stroke. Despite substantial research efforts, biological mechanisms are incomplete and biomarkers indicating WMLs are lacking. Utilizing data from the population-based Study of Health in Pomerania (SHIP), our objective was to identify plasma-circulating micro-RNAs (miRNAs) associated with WMLs, thus providing a foundation for a comprehensive biological model and further research. In linear regression models, direct association and moderating factors were analyzed. In 648 individuals, we identified hsa-miR-425-5p as directly associated with WMLs. In subsequent analyses, hsa-miR-425-5p was found to regulate various genes associated with WMLs with particular emphasis on the SH3PXD2A gene. Furthermore, miR-425-5p was found to be involved in immunological processes. In addition, noteworthy miRNAs associated with WMLs were identified, primarily moderated by the factors of sex or smoking status. All identified miRNAs exhibited a strong over-representation in neurodegenerative and neurological diseases. We introduced hsa-miR-425-5p as a promising candidate in WML research probably involved in immunological processes. Mir-425-5p holds the potential as a biomarker of WMLs, shedding light on potential mechanisms and pathways in vascular dementia.

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Charting the Next Road Map for CSF Biomarkers in Alzheimer's Disease and Related Dementias

Cited by 3 publications

References 212 publications

Editorial: Alzheimer-related affective symptoms – mechanism and treatment

Editorial: Alzheimer-related affective symptoms – mechanism and treatment

Lessons Learned in Time—Is Neurodegeneration Still Something Unpredictable?

Circulating microRNA miR-425-5p Associated with Brain White Matter Lesions and Inflammatory Processes

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