Charting human subcortical maturation across the adult lifespan with in vivo 7 T MRI

Miletić, Steven; Bazin, Pierre‐Louis; Isherwood, S.J.S.; Keuken, Max C.; Alkemade, Anneke; Forstmann, Birte U.

doi:10.1016/j.neuroimage.2022.118872

Cited by 19 publications

(11 citation statements)

References 113 publications

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“…As such, the diamagnetic properties of myelin or calcifications can be distinguished from the paramagnetic properties of iron by QSM, in comparison to other methods such as R2*. While post-mortem studies have validated QSM as a proxy for iron ( Langkammer et al, 2012 ), with a correlation of r = 0.84 between QSM and chemically determined iron concentration in grey matter, it has to be acknowledged that other minerals [e.g., copper, manganese, and calcium, albeit contribution may be small ( Schenck and Zimmerman, 2004 ), presence of microbleeds, and myelin may contribute to the averaged QSM signal within a region of interest given their diamagnetic or paramagnetic properties ( Haacke et al, 2005 ; Sedlacik et al, 2007 ; Schweser et al, 2011 ; Lee et al, 2012 ; Stüber et al, 2014 ; Miletić et al, 2022 )]. Presence of diamagnetic elements causes R2* to overestimate iron content and QSM to underestimate it ( Haacke et al, 2005 ).…”

Section: Discussionmentioning

confidence: 99%

Contributions of the Catechol-O-Methyltransferase Val158Met Polymorphism to Changes in Brain Iron Across Adulthood and Their Relationships to Working Memory

Gustavsson

Papenberg

Falahati

et al. 2022

Front. Hum. Neurosci.

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Ageing is associated with excessive free brain iron, which may induce oxidative stress and neuroinflammation, likely causing cognitive deficits. Lack of dopamine may be a factor behind the increase of iron with advancing age, as it has an important role in cellular iron homoeostasis. We investigated the effect of COMT Val 158 Met (rs4680), a polymorphism crucial for dopamine degradation and proxy for endogenous dopamine, on iron accumulation and working memory in a longitudinal lifespan sample (n = 208, age 20–79 at baseline, mean follow-up time = 2.75 years) using structural equation modelling. Approximation of iron content was assessed using quantitative susceptibility mapping in striatum and dorsolateral prefrontal cortex (DLPFC). Iron accumulated in both striatum and DLPFC during the follow-up period. Greater iron accumulation in DLPFC was associated with more deleterious change in working memory. Older (age 50–79) Val homozygotes (with presumably lower endogenous dopamine) accumulated more iron than older Met carriers in both striatum and DLPFC, no such differences were observed among younger adults (age 20–49). In conclusion, individual differences in genetic predisposition related to low dopamine levels increase iron accumulation, which in turn may trigger deleterious change in working memory. Future studies are needed to better understand how dopamine may modulate iron accumulation across the human lifespan.

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Section: Discussionmentioning

confidence: 99%

Contributions of the Catechol-O-Methyltransferase Val158Met Polymorphism to Changes in Brain Iron Across Adulthood and Their Relationships to Working Memory

Gustavsson

Papenberg

Falahati

et al. 2022

Front. Hum. Neurosci.

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“…A key requirement for targeting this system in therapeutic interventions is the ability to localize it accurately in the human brain. New methods for localizing subcortical structures are effective for identifying small nuclei, including the ZI [156]. Here we have shown the feasibility of reconstructing the projections of the ZI using tractography on human diffusion MRI data acquired in vivo at sub-mm resolution.…”

Section: Links To the Basal Gangliamentioning

confidence: 89%

The rostral zona incerta: a subcortical integrative hub and potential DBS target for OCD

Haber

Lehman

Maffei

et al. 2022

Preprint

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Background: The zona incerta (ZI) is involved in mediating survival behaviors and is connected to a wide range of cortical and subcortical structures, including key basal ganglia nuclei. Based on these connections and their links to behavioral modulation, we propose the ZI is a connectional hub for mediating between top-down and bottom-up control and a possible target for deep brain stimulation for obsessive compulsive disorder. Methods: We analyzed the trajectory of cortical fibers to the ZI in nonhuman and human primates, based on tracer injections in monkeys and high-resolution diffusion MRI in humans. The organization of cortical and subcortical connections with the ZI were identified in the nonhuman primate studies. Results: Monkey anatomic data and human dMRI data showed a similar trajectory of fibers/streamlines to the ZI. PFC/ACC terminals all converge within the rostral ZI (ZIr), with dorsal and lateral areas most prominent. Motor areas terminate caudally. Dense subcortical reciprocal connections included the thalamus, medial hypothalamus, substantia nigra/ventral tegmental area, reticular formation, and pedunculopontine nucleus and a dense nonreciprocal projection to the lateral habenula (LHb). Additional connections included amygdala, dorsal raphe nucleus, and periaqueductal grey. Conclusions: Dense connections with dorsal and lateral PFC/ACC cognitive control areas and LHb and SN/VTA coupled with inputs from the amygdala, hypothalamus, and brainstem, suggests that the ZIr is a subcortical hub positioned to modulate between top-down and bottom-up control. A DBS electrode placed in the ZIr would involve both connections common to other DBS sites, but also would capture several critically distinctive connections.

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“…Subcortical volumes are also another set of metrics derived from FreeSurfer that are of major interest to neuroimaging researchers (Ohi et al, 2020 ; Satizabal et al, 2019 ). Efforts to provide references of normative subcortical volume changes that occur as a result of aging have been put forth (Bethlehem et al, 2022 ; Coupé et al, 2017 ; Dima et al, 2022 ; Miletić et al, 2022 ; Narvacan et al, 2017 ; Potvin et al, 2016 ). For example, Potvin et al, 2016 pooled data from 21 research groups ( n = 2790) and segmented subcortical volumes using FreeSurfer v5.3 to provide norms of volumetric estimate changes during healthy aging.…”

Section: Discussionmentioning

confidence: 99%

Multisite test–retest reliability and compatibility of brain metrics derived from FreeSurfer versions 7.1, 6.0, and 5.3

Haddad

Pizzagalli

Zhu

et al. 2022

Human Brain Mapping

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Automatic neuroimaging processing tools provide convenient and systematic methods for extracting features from brain magnetic resonance imaging scans. One tool, FreeSurfer, provides an easy‐to‐use pipeline to extract cortical and subcortical morphometric measures. There have been over 25 stable releases of FreeSurfer, with different versions used across published works. The reliability and compatibility of regional morphometric metrics derived from the most recent version releases have yet to be empirically assessed. Here, we used test–retest data from three public data sets to determine within‐version reliability and between‐version compatibility across 42 regional outputs from FreeSurfer versions 7.1, 6.0, and 5.3. Cortical thickness from v7.1 was less compatible with that of older versions, particularly along the cingulate gyrus, where the lowest version compatibility was observed (intraclass correlation coefficient 0.37–0.61). Surface area of the temporal pole, frontal pole, and medial orbitofrontal cortex, also showed low to moderate version compatibility. We confirm low compatibility between v6.0 and v5.3 of pallidum and putamen volumes, while those from v7.1 were compatible with v6.0. Replication in an independent sample showed largely similar results for measures of surface area and subcortical volumes, but had lower overall regional thickness reliability and compatibility. Batch effect correction may adjust for some inter‐version effects when most sites are run with one version, but results vary when more sites are run with different versions. Age associations in a quality controlled independent sample ( N = 106) revealed version differences in results of downstream statistical analysis. We provide a reference to highlight the regional metrics that may yield recent version‐related inconsistencies in published findings. An interactive viewer is provided at http://data.brainescience.org/Freesurfer_Reliability/ .

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Charting human subcortical maturation across the adult lifespan with in vivo 7 T MRI

Cited by 19 publications

References 113 publications

Contributions of the Catechol-O-Methyltransferase Val158Met Polymorphism to Changes in Brain Iron Across Adulthood and Their Relationships to Working Memory

Contributions of the Catechol-O-Methyltransferase Val158Met Polymorphism to Changes in Brain Iron Across Adulthood and Their Relationships to Working Memory

The rostral zona incerta: a subcortical integrative hub and potential DBS target for OCD

Multisite test–retest reliability and compatibility of brain metrics derived from FreeSurfer versions 7.1, 6.0, and 5.3

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