Chartarlactams Q−T, Dimeric Phenylspirodrimanes with Antibacterial and Antiviral Activities

Liu, Dong; Li, Yong; Guo, Xingchen; Ji, Wei; Lin, Wenhan

doi:10.1002/cbdv.202000170

Cited by 16 publications

(12 citation statements)

References 21 publications

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“…Some of these compounds exhibited antihyperlipidemic effects on HepG2 cells, such as inhibition of intracellular triglyceride (TG) levels and reduction of total cholesterol (TC), but the mechanism of antihyperlipidemic activity remains unknown. The same group reported four new phenylspirodrimane-type dimers in 2020, which showed antibacterial (MIC: 4−16 μg/mL) and antiviral activities (Liu et al 2020).…”

Section: Terpenoid Alkaloidsmentioning

confidence: 98%

Peculiarities of meroterpenoids and their bioproduction

Han

Jiang

Zhang

et al. 2021

Appl Microbiol Biotechnol

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Meroterpenoids are a class of terpenoid-containing hybrid natural products with impressive structural architectures and remarkable pharmacological activities. Remarkable advances in enzymology and synthetic biology have greatly contributed to the elucidation of the molecular basis for their biosynthesis. Here, we review structurally unique meroterpenoids catalyzed by novel enzymes and unusual enzymatic reactions over the period of last five years. We also discuss recent progress on the biomimetic synthesis of chrome meroterpenoids and synthetic biology driven biomanufacturing of tropolone sesquiterpenoids, merochlorins, and plant-derived meroterpenoid cannabinoids. In particular, we focus on the novel enzymes involved in the biosynthesis of polyketide-terpenoids, nonribosomal peptide-terpenoids, terpenoid alkaloids, and meroterpenoid with unique structures. The biological activities of these meroterpenoids are also discussed. The information reviewed here might provide useful clues and lay the foundation for developing new meroterpenoid-derived drugs. Key points• Meroterpenoids possess intriguing structural features and relevant biological activities.• Novel enzymes are involved in the biosynthesis of meroterpenoids with unique structures.• Biomimetic synthesis and synthetic biology enable the construction and manufacturing of complex meroterpenoids.

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Section: Terpenoid Alkaloidsmentioning

confidence: 98%

Peculiarities of meroterpenoids and their bioproduction

Han

Jiang

Zhang

et al. 2021

Appl Microbiol Biotechnol

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“…Four new phenylspirodrimane-type dimers namely chartarlactams Q–T ( 189 – 192 ), were isolated from the fermentation-broth of a sponge-derived fungus Stachybotrys chartarum WGC-25C-6. Compounds 189 – 191 showed moderate inhibition against bacterial pathogen Staphylococcus aureus with MIC values ranging from 4 to 16 μg/mL, while compound 192 exhibited significant inhibition toward ZIKV virus [ 53 ]. Meanwhile, chartarene D ( 193 ), was isolated from the sponge ( Niphates recondite )-associated fungus Stachybotrys chartarum [ 12 ].…”

Section: New Mnps From the Beibu Gulfmentioning

confidence: 99%

Marine Natural Products from the Beibu Gulf: Sources, Chemistry, and Bioactivities

et al. 2023

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Marine natural products (MNPs) play an important role in the discovery and development of new drugs. The Beibu Gulf of South China Sea harbors four representative marine ecosystems, including coral reefs, mangroves, seaweed beds, and coastal wetlands, which are rich in underexplored marine biological resources that produce a plethora of diversified MNPs. In our ongoing efforts to discover novel and biologically active MNPs from the Beibu Gulf, we provide a systematic overview of the sources, chemical structures, and bioactive properties of a total of 477 new MNPs derived from the Beibu Gulf, citing 133 references and covering the literature from the first report in November 2003 up to September 2022. These reviewed MNPs were structurally classified into polyketides (43%), terpenoids (40%), nitrogen-containing compounds (12%), and glucosides (5%), which mainly originated from microorganisms (52%) and macroorganisms (48%). Notably, they were predominantly found with cytotoxic, antibacterial, and anti-inflammatory activities. This review will shed light on these untapped Beibu Gulf-derived MNPs as promising lead compounds for the development of new drugs.

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“…Envelope (E) protein in ZIKV virus has a remarkable role in membrane fusion and binding to target the host cells receptors, whereas NS5 protein a ZIKV genome encoding non-structural proteins that serves as template for the (+)ssRNA genomic RNA synthesis and viral polyprotein synthesis. Hence, this metabolite prohibited ZIKV virus by multi-targets to block RNA replication and viral entrance [ 86 ]. Biosynthetically, they are generated from 3 that undergoes nucleophilic cyclization to give I (hemiacetal intermediate).…”

Section: Secondary Metabolites From S Chartarummentioning

confidence: 99%

Stachybotrys chartarum—A Hidden Treasure: Secondary Metabolites, Bioactivities, and Biotechnological Relevance

Ibrahim

Choudhry

Asseri

et al. 2022

JoF

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Fungi are renowned as a fountainhead of bio-metabolites that could be employed for producing novel therapeutic agents, as well as enzymes with wide biotechnological and industrial applications. Stachybotrys chartarum (black mold) (Stachybotriaceae) is a toxigenic fungus that is commonly found in damp environments. This fungus has the capacity to produce various classes of bio-metabolites with unrivaled structural features, including cyclosporins, cochlioquinones, atranones, trichothecenes, dolabellanes, phenylspirodrimanes, xanthones, and isoindoline and chromene derivatives. Moreover, it is a source of various enzymes that could have variable biotechnological and industrial relevance. The current review highlights the formerly published data on S. chartarum, including its metabolites and their bioactivities, as well as industrial and biotechnological relevance dated from 1973 to the beginning of 2022. In this work, 215 metabolites have been listed and 138 references have been cited.

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Chartarlactams Q−T, Dimeric Phenylspirodrimanes with Antibacterial and Antiviral Activities

Cited by 16 publications

References 21 publications

Peculiarities of meroterpenoids and their bioproduction

Peculiarities of meroterpenoids and their bioproduction

Marine Natural Products from the Beibu Gulf: Sources, Chemistry, and Bioactivities

Stachybotrys chartarum—A Hidden Treasure: Secondary Metabolites, Bioactivities, and Biotechnological Relevance

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