Chart Review of the Impact of Attention-Deficit/Hyperactivity Disorder Comorbidity on Response to Lithium or Divalproex Sodium in Adolescent Mania

State, Rosanne C.; Frye, Mark A.; Altshuler, Lori L.; Strober, Michael; DeAntonio, Mark; Hwang, Sun; Mintz, Jim

doi:10.4088/jcp.v65n0805

Cited by 52 publications

(33 citation statements)

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“…4 It is noteworthy, however, that the presence of comorbid ADHD as well as other disruptive behavioral disorders predicts a poorer response to treatment, 5 with these comorbidities requiring independent clinical attention.…”

Section: Discussionmentioning

confidence: 99%

Treatment-Resistant Juvenile Bipolar Disorder with Psychosis

Ambilichu¹,

McCormick²,

Fatima³

et al. 2014

Psychiatric Annals

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Section: Discussionmentioning

confidence: 99%

Treatment-Resistant Juvenile Bipolar Disorder with Psychosis

Ambilichu¹,

McCormick²,

Fatima³

et al. 2014

Psychiatric Annals

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“…Four reports offered sufficiently detailed data for the metaanalysis. [7][8][9][10] One team sent us unpublished detailed data for inclusion in the study. 11 One no longer had available raw data.…”

Section: Discussionmentioning

confidence: 99%

“…In only 2 trials was there a significant decrease in treatment response related to ADHD comorbidity. 7,8 However, when the 5 trials were combined, there was a moderate and significant reduction in RR that favoured treatment response in acute episodes among children and adolescents with BD but without comorbid ADHD (Figure 1 shows a pooled RR of 0.822; 95%CI, 0.69 to 0.97; P = 0.021).…”

Section: The Effect Of Adhd Comorbidity On Response To Treatment In Ymentioning

confidence: 99%

“…· One study 7 was a retrospective chart review and had the largest difference in response rates (Figure 1). However, the study only had a 15% weight in the metaanalysis.…”

Section: Limitationsmentioning

confidence: 99%

“…Secondary analyses were performed after we subgrouped studies with adolescents only, 7,8,10 in comparison with others, 9,11 and studies with subjects having BD I only, 7,8,10,11 in comparison with others. 9 As hypothesized, the effect of existing comorbid ADHD on treatment response was higher in studies including adolescents only.…”

Section: The Effect Of Adhd Comorbidity On Response To Treatment In Ymentioning

confidence: 99%

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Comorbidity with ADHD Decreases Response to Pharmacotherapy in Children and Adolescents with Acute Mania: Evidence from a Metaanalysis

et al. 2007

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Objective: To assess whether comorbid attention-deficit hyperactivity disorder (ADHD) influences response to treatment in young patients with acute mania. Methods:We conducted a metaanalysis of 5 open trials of 100, 35, 41, 60, and 37 children and adolescents. The pooled group included 273 children and adolescents with bipolar disorder (BD), divided into 2 subgroups: those with (n = 132), and those without (n = 141), ADHD comorbidity.Results: There was a moderate and significant reduction in relative risk (RR) favouring treatment response in children and adolescents with BD but without ADHD comorbidity (RR 0.822; 95%CI, 0.69 to 0.97; P = 0.021). The negative effect of ADHD comorbidity on treatment response was more significant in studies including adolescents only or subjects with BD I only. Conclusion:These findings suggest that children and adolescents with BD and ADHD tend to be less responsive to drugs used in treatment of acute mania. Clinical Implications · BD in prepubertal children may differ from BD in adolescents. · Evidence-based data concerning the treatment of children and adolescents with BD are lacking. · Comorbidity with ADHD may limit pharmacologic treatment response in children and adolescents with BD. Limitations ·The metaanalysis included open trials only, with no standardized procedure for clinical assessment of BD and (or) ADHD symptomatology and with heterogeneous study design. · Consequently, the metaanalysis had only 273 subjects, and we could not distinguish between the treatments used in the studies.

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Anticonvulsants Used in Child and Adolescent Psychiatric Disorders

Pavuluri

Mayanil

2012

Pharmacotherapy of Child and Adolescent Psychiatric Disorders

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Chart Review of the Impact of Attention-Deficit/Hyperactivity Disorder Comorbidity on Response to Lithium or Divalproex Sodium in Adolescent Mania

Cited by 52 publications

References 0 publications

Treatment-Resistant Juvenile Bipolar Disorder with Psychosis

Treatment-Resistant Juvenile Bipolar Disorder with Psychosis

Comorbidity with ADHD Decreases Response to Pharmacotherapy in Children and Adolescents with Acute Mania: Evidence from a Metaanalysis

Anticonvulsants Used in Child and Adolescent Psychiatric Disorders

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