Charlson comorbidity index helps predict the risk of mortality for patients with type 2 diabetic nephropathy

Abstract

Abstract:Our intent is to examine the predictive role of Charlson comorbidity index (CCI) on mortality of patients with type 2 diabetic nephropathy (DN). Based on the CCI score, the severity of comorbidity was categorized into three grades: mild, with CCI scores of 1-2; moderate, with CCI scores of 3-4; and severe, with CCI scores ≥5. Factors influencing mortality and differences between groups stratified by CCI were determined by logistical regression analysis and one-way analysis of variance (ANOVA). The impact of CCI on mortality was assessed by the KaplanMeier analysis. A total of 533 patients with type 2 DN were enrolled in this study, all of them had comorbidity (CCI score >1), and 44.7% (238/533) died. The mortality increased with CCI scores: 21.0% (50/238) patients with CCI scores of 1-2, 56.7% (135/238) patients with CCI scores of 3-4, and 22.3% (53/238) patients with CCI scores ≥5. Logistical regression analysis showed that CCI scores, hemoglobin, and serum albumin were the potential predictors of mortality (P<0.05). One-way ANOVA analysis showed that DN patients with higher CCI scores had lower levels of hemoglobulin, higher levels of serum creatinine, and higher mortality rates than those with lower CCI scores. The Kaplan-Meier curves showed that survival time decreased when the CCI scores and mortality rates went up. In conclusion, CCI provides a simple, readily applicable, and valid method for classifying comorbidities and predicting the mortality of type 2 DN. An increased awareness of the potential comorbidities in type 2 DN patients may provide insights into this complicated disease and improve the outcomes by identifying and treating patients earlier and more effectively.

Prophylaxis for Stress Ulcers With Proton Pump Inhibitors Is Not Associated With Increased Risk of Bloodstream Infections in the Intensive Care Unit

“…CCI was dichotomized as a score of 2 or less, considered mild, versus 3 or greater, considered moderate to severe. 24 …”

The significance of micro- and macrovascular biomarkers on cardiovascular outcome in chronic kidney disease: a prospective cohort study

“…The Charlson Comorbidity Index was used for overall characterization of comorbidity of the studied population. 22,23 Data on haemoglobin, serum calcium, phosphate, albumin, parathormon, creatinine, C-reactive protein, serum cholesterol, triglyceride, and low-density lipoprotein cholesterol were evaluated at baseline. Routine blood chemistry measurements were performed by a Hitachi (Uster, Switzerland) auto analyser.…”

Predictors for self‐management in older adults with type 2 diabetic nephropathy

“…Compared with other studies, the gender proportion in our study varied. Regarding diabetes history, the average in previous studies was 7.1–18 years (Abu et al, ; Pérez‐Manchón, Redondo‐Pico, & Ramos‐Quirós, ; Edward et al, ; Hara et al, ; Huang et al, ; Ishak, Mohd Yusoff, Rahman, & Kadir, ), and the mean HbA1c value ranged from 7.3% to 9.21% (Abu et al, ; Ballotari et al, ; Hara et al, ; Ishak et al, ). Patients who received an elementary school/junior high school education accounted for 65% to 72.6% of the participants, while the education level was lower in our study (Ishak et al, ; Pérez‐Manchón et al, ; Thojampa & Mawn, ).…”

“…A higher score indicates a more severe disease burden, which can be used to predict one‐year mortality (Charlson, Pompei, Ales, & MacKenzie, ; Charlson, Szatrowski, Peterson, & Gold, ). The CCI can also be used to predict the prognosis and mortality of type 2 diabetic nephropathy (Huang et al, ).…”