A periodised case study is offered of a number of engagements undertaken by The Centre for Communication, Media and Society, University of KwaZulu-Natal, Durban, between 1985 and 2012 in facilitating resistance, policy, development and analysis. How cultural and media studies travelled to South Africa and how the Centre negotiated the intersections between the Humanities and Social Sciences, Health and the Physical Sciences, is examined in terms of the epistemological alliances and conflicts that emerged. New paradigms ranging from appropriations of African philosophy and critical indigenous methodologies are discussed in an environment where new nationalisms are emerging. The story of the Centre offers the fulcrum around which to discuss specific paradigmatic shifts. A new imaginary for the Humanities and Social Sciences for a rapidly changing South Africa is then briefly proposed.