2013
DOI: 10.1534/genetics.113.151241
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Charles Darwin’s Mitochondria

Abstract: Charles Darwin’s long-term illness has been the subject of much speculation. His numerous symptoms have led to conclusions that his illness was essentially psychogenic in nature. These diagnoses have never been fully convincing, however, particularly in regard to the proposed underlying psychological background causes of the illness. Similarly, two proposed somatic causes of illness, Chagas disease and arsenic poisoning, lack credibility and appear inconsistent with the lifetime history of the illness. Other p… Show more

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Cited by 16 publications
(18 citation statements)
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“…Observation were recorded on eight quantitative traits viz., days to first female flower opening, days to first fruit set, days to first fruit harvest, fruit length (cm), fruit width (cm), average fruit weight (g), number of fruits per plant and fruit yield per plant (g). Gene action was studied by the diallel method of numerical approach given by [4]: D = Component of variation due to additive effects of genes. H1 = Component of variation due to dominance effect of genes.…”
Section: Methodsmentioning
confidence: 99%
“…Observation were recorded on eight quantitative traits viz., days to first female flower opening, days to first fruit set, days to first fruit harvest, fruit length (cm), fruit width (cm), average fruit weight (g), number of fruits per plant and fruit yield per plant (g). Gene action was studied by the diallel method of numerical approach given by [4]: D = Component of variation due to additive effects of genes. H1 = Component of variation due to dominance effect of genes.…”
Section: Methodsmentioning
confidence: 99%
“…Other conditions proposed include various gut ailments, such as cyclic vomiting syndrome, and Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke‐like episodes (MELAS), involving an inherited mitochondrial mutation (Hayman, ; Finsterer & Hayman, ), irritable bowel syndrome (IBS) (Shanahan, ), and Crohn's disease (Orrego & Quintana, ). His regular bouts of vomiting certainly fit the diagnosis of cyclic vomiting syndrome (Hayman, , b, ), which is associated with nausea, abdominal pain and dyspepsia. But, this does not explain all the other symptoms from which Darwin suffered.…”
Section: The Natural History Of Darwin's Illnessmentioning
confidence: 99%
“…See (Colp, 1960(Colp, , 1977(Colp, , 1983(Colp, , 2000(Colp, , 2006 M eni ere's spectrum disorder (Gordon, 2009a, b) Systemic lactose intolerance (Campbell, 2003;Campbell, & Matthews 2005a, b;Campbell et al, 2005b;Dixon & Radick, 2009) MELAS from mitochondrial gene mutation (Hayman, 2013b;Finsterer & Hayman, 2014) Gout (Darwin, 1876;Colp, 2006) Hyperinsulinism (Lichfield, 2015) Malaria (Hayman, 2009a(Hayman, , 2013) Systemic lupus erythematosis (Hayman, 2009a(Hayman, , 2013 Pyroluria (Hayman, 2009a(Hayman, , 2013) Irritable bowel syndrome (Shanahan, 2012) Crohn's disease (Orrego & Quintana, 2007) Fearing he had had a heart attack, Darwin told no one, lest he was not allowed on his voyage of a lifetime. He only admitted to this in his autobiography (Darwin, 1876(Darwin, , 1902.…”
Section: Amoeba Infectionmentioning
confidence: 99%
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