This research examines how the treatment philosophy and clinical practice of the Teen Challenge USA (TC)–-a national network of faith-based recovery services–-differ from secular substance abuse treatment programs. Using survey data from 80 TC administrators and counselors and 68 non-TC counterparts randomly selected from secular providers of substance abuse treatment, TC and non-TC providers were compared on these dimensions: views on human nature and morality perspectives on substance abuse and its treatment, structural capacity of the program and facilities, characteristics of the treatment population, service availability and utilization, and staff profiles. Findings revealed important differences as well as interesting similarities between TC and non-TC programs. Recommendations based on these findings are offered to both faith-based and secular service providers.