Charged hadron tumour therapy monitoring by means of PET

Enghardt, W.; Crespo, Paulo; Fiedler, F.; Hinz, Rainer; Parodi, Katia; Pawelke, Jörg; Pönisch, Falk

doi:10.1016/j.nima.2004.03.128

Cited by 348 publications

(284 citation statements)

References 20 publications

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“…However, clinical, online PET data are lacking for proton therapy, where the limitation to target fragmentation represents a major difference with respect to the in-beam PET of carbon-ion therapy (2,3). Proton-induced activity is more sensitive to tissue elemental composition and metabolism.…”

Section: Discussionmentioning

confidence: 99%

Patient Study of In Vivo Verification of Beam Delivery and Range, Using Positron Emission Tomography and Computed Tomography Imaging After Proton Therapy

Parodi

Paganetti

Shih

et al. 2007

International Journal of Radiation Oncology*Biology*Physics

365

441

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Purpose-To investigate the feasibility and value of positron emission tomography and computed tomography (PET/CT) for treatment verification after proton radiotherapy.Methods and Materials-This study included 9 patients with tumors in the cranial base, spine, orbit, and eye. Total doses of 1.8-3 GyE and 10 GyE (for an ocular melanoma) per fraction were delivered in 1 or 2 fields. Imaging was performed with a commercial PET/CT scanner for 30 min, starting within 20 min after treatment. The same treatment immobilization device was used during imaging for all but 2 patients. Measured PET/CT images were coregistered to the planning CT and compared with the corresponding PET expectation, obtained from CT-based Monte Carlo calculations complemented by functional information. For the ocular case, treatment position was approximately replicated, and spatial correlation was deduced from reference clips visible in both the planning radiographs and imaging CT. Here, the expected PET image was obtained from an analytical model.Results-Good spatial correlation and quantitative agreement within 30% were found between the measured and expected activity. For head-and-neck patients, the beam range could be verified with an accuracy of 1-2 mm in well-coregistered bony structures. Low spine and eye sites indicated the need for better fixation and coregistration methods. An analysis of activity decay revealed as tissueeffective half-lives of 800-1,150 s.Conclusions-This study demonstrates the feasibility of postradiation PET/CT for in vivo treatment verification. It also indicates some technological and methodological improvements needed for optimal clinical application.

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Section: Discussionmentioning

confidence: 99%

Patient Study of In Vivo Verification of Beam Delivery and Range, Using Positron Emission Tomography and Computed Tomography Imaging After Proton Therapy

Parodi

Paganetti

Shih

et al. 2007

International Journal of Radiation Oncology*Biology*Physics

365

441

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“…Other imaging modalities, like ion-induced ultrasounds, appear promising in some specic cases [3]. The main imaging modality that has already been applied clinically is positron emission tomography (PET) [4]. Positron emitters are created during fragmentation of projectiles (carbon therapy) or target nuclei (any kind of particle therapy).…”

Section: Rationalementioning

confidence: 99%

“…A 32-channel ASIC readout front-end of the PMTs comprises a current-conveyor with comparator and analog output, and a delayed-locked-loop digital timing with 60 ps resolution [29]. 4. Conclusions Prompt-gamma imaging has proven its ability to monitor online hadrontherapy.…”

Section: Device Developmentsmentioning

confidence: 99%

Prompt-Gamma Monitoring of Proton- and Carbon-Therapy. Combined Development of Time-of-Flight Collimated- and Compton-Cameras

et al. 2015

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Prompt-gamma imaging during ion therapy has proven its ability to control the ion range in real time. The achievable precision is of the order of the millimeter for a single spot in proton pencil beam scanning. Collimated gamma cameras have been developed, that are close to clinical application. The Compton cameras are also under development in various laboratories. Time of ight enables the reduction of the background due to other prompt radiations.

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“…In order to reduce these margins and deliver a safer treatment, a device for the real-time monitoring of the range inside the patient would be useful. Several techniques have been explored for this purpose: PET monitoring which was used off line [3] and on line [2], the use of other two types of secondary particles emerging from patient, (i) prompt gamma [4][5] and charged particles, in particular protons (for carbon beams) [6] [7]. The present paper focuses on proton imaging (IVI method) in the frame of the QAPIVI (Quality Assurance by Protons Vertex Imaging) project.…”

Section: Introductionmentioning

confidence: 99%