Charge-reversal nanomedicines as a smart bullet for deep tumor penetration

Li, Zimu; Gao, Yuanzhu; Li, Wen; Li, Yongyuan; Lv, Hang; Zhang, Dan; Peng, Jingwen; Cheng, Wei; Mei, Lin; Chen, Hongzhong; Zeng, Xiaowei

doi:10.1016/j.smaim.2022.01.008

Cited by 59 publications

(18 citation statements)

References 85 publications

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“…Radiation therapy (RT) is one of the mainstream tumor treatments alongside chemotherapy and surgery. 4,5 In the current clinical cancer treatment, about half of the cancer patients will use radiotherapy or combine it with other treatment methods in the process of cancer treatment. 6 Radiotherapy is a key method in the treatment of malignant tumors, and its role and status are becoming increasingly prominent.…”

Section: Introductionmentioning

confidence: 99%

Research progress on nano-sensitizers for enhancing the effects of radiotherapy

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Research progress on nano-sensitizers for enhancing the effects of radiotherapy

et al. 2022

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“…The combination approach improves the therapeutic regime, like conjugating PDT could enhance the therapeutic effect of not only the repurposed drugs but also active prodrugs at the tumor site. The optimized proportion of drug and PS loaded within a suitable nanosystem provides comprehensive antitumor therapy for both in vitro and in vivo systems with efficient transcytosis in the tumor region and low systemic toxicity. − …”

Section: Resultsmentioning

confidence: 99%

In Vitro Therapeutic Attributes of Luminescent Hydroxyapatite Nanoparticles in Codelivery Module

Simon

Chattopadhyay

Ghosh

2022

ACS Appl. Bio Mater.

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Imminent prospects of clinical importance have been accomplished through divergent treatment modalities implemented using nanoscale platforms. In the present study, hydroxyapatite nanoparticles doped with copper nanoclusters (HAPs) were explored for codelivery of a hydrophobic drug, namely, norfloxacin (NX), and a hydrophilic photosensitizer, such as methylene blue (MB). NX and MB were successfully homed into HAPs (MB-NX-HAPs), which further exhibited a pH-dependent release of both. With the objective of attaining an enhanced effect, MB-NX-HAPs were evaluated for combination therapy, involving chemotherapy and photodynamic therapy (PDT) with irradiation at 640 nm. The combinatorial therapy approach was initially applied for antibacterial therapy, which suggested a considerable reduction in bacterial growth of Gram-negative strain Pseudomonas aeruginosa MTCC 2488. Thereafter, the antiproliferative study performed in cancer cell lines (HeLa and MCF-7) revealed the efficiency of MB-NX-HAPs in bestowing a combinatorial effect through chemotherapy and PDT (irradiation at 640 nm). The combined effect exerted through MB-NX-HAPs subsequently induced reactive oxygen species (ROS) generation, cell cycle alteration, and apoptosis activation in cancer cells. The biocompatible nature of MB-NX-HAPs was appreciably shown through their minimal effect on the normal cell line (HEK-293). Additionally, HAPs through luminescence of copper nanoclusters were suggested to aid in bioimaging of cancer cell lines.

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“…11 Consistently, ROS-targeting therapies have exhibited great promise in preclinical studies, yet traditional antioxidants such as vitamin C, vitamin E, and Nacetylcysteine have failed to achieve clear efficacy in a clinical context, 12−14 with no antioxidant drugs being routinely used in clinical practice at present. In recent years, huge progress has been made in nanomaterials applied in almost all areas of medicine for therapeutic and diagnosis purposes, such as tumor, 15,16 ischemic stroke, 17,18 infectious disease, 19,20 autoimmune disease, 21,22 and impaired wound healing. 23 Nanozymes are small, enzymelike nanomaterials that exhibit many clinical advantages owing to their excellent stability, high levels of activity, good scalability, low costs, and ready applicability to use in caustic environments.…”

Section: Introductionmentioning

confidence: 99%

Thermosensitive Hydrogel Incorporating Prussian Blue Nanoparticles Promotes Diabetic Wound Healing via ROS Scavenging and Mitochondrial Function Restoration

Zhao

Liu

et al. 2022

ACS Appl. Mater. Interfaces

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Diabetic foot ulcer is a serious complication in diabetes patients, imposing a serious physical and economic burden to patients and to the healthcare system as a whole. Oxidative stress is thought to be a key driver of the pathogenesis of such ulcers. However, no antioxidant drugs have received clinical approval to date, underscoring the need for the further development of such medications. Hydrogels can be applied directly to the wound site, wherein they function to prevent infection and maintain local moisture concentrations, in addition to serving as a reservoir for the delivery of a range of therapeutic compounds with the potential to expedite wound healing in a synergistic manner. Herein, we synthesized Prussian blue nanoparticles (PBNPs) capable of efficiently scavenging reactive oxygen species (ROS) owing to their ability to mimic the activity of catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD). In the context of in vitro oxidative stress, these PBNPs were able to protect against cytotoxicity, protect mitochondria from oxidative stress-related damage, and restore nuclear factor erythroid 2-related factor 2 (NRF2)/heme oxygenase-1 (HO-1) pathway activity. To expand on these results in an in vivo context, we prepared a thermosensitive poly (d,L-lactide)-poly(ethylene glycol)-poly(d,L-lactide) (PDLLA-PEG-PDLLA) hydrogel (PLEL)-based wound dressing in which PBNPs had been homogenously incorporated, and we then used this dressing as a platform for controlled PBNP release. The resultant PBNPs@PLEL wound dressing was able to improve diabetic wound healing, decrease ROS production, promote angiogenesis, and reduce pro-inflammatory interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels within diabetic wounds. Overall, our results suggest that this PBNPs@PLEL platform holds great promise as a treatment for diabetic foot ulcers.

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Charge-reversal nanomedicines as a smart bullet for deep tumor penetration

Cited by 59 publications

References 85 publications

Research progress on nano-sensitizers for enhancing the effects of radiotherapy

Research progress on nano-sensitizers for enhancing the effects of radiotherapy

In Vitro Therapeutic Attributes of Luminescent Hydroxyapatite Nanoparticles in Codelivery Module

Thermosensitive Hydrogel Incorporating Prussian Blue Nanoparticles Promotes Diabetic Wound Healing via ROS Scavenging and Mitochondrial Function Restoration

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