The search of a sweet spot, locus in qubit parameters where quantum control is first-order insensitive to noises, is key to achieve high-fidelity quantum gates. Efforts to search for such a sweet spot in conventional double-quantum-dot singlet-triplet qubits where each dot hosts one electron ("two-electron singlet-triplet qubit"), especially for two-qubit operations, have been unsuccessful. Here we consider singlet-triplet qubits allowing each dot to host more than one electron, with a total of four electrons in the double quantum dots ("four-electron singlet-triplet qubit"). We theoretically demonstrate, using configuration-interaction calculations, that sweet spots appear in this coupled qubit system. We further demonstrate that, under realistic charge noise and hyperfine noise, two-qubit operation at the proposed sweet spot could offer gate fidelities (∼ 99%) that are higher than conventional two-electron singlet-triplet qubit system (∼ 90%). Our results should facilitate realization of high-fidelity two-qubit gates in singlet-triplet qubit systems.