Charge effect of water-soluble porphyrin derivatives as a prototype to fight infections caused by <i>Acinetobacter baumannii</i> by aPDT approaches

Caprara, Carolina da Silva Canielles; Freitas, Livia da Silva; Iglesias, Bernardo A.; Ferreira, Lara Beatriz; Ramos, Daniela Fernandes

doi:10.1080/08927014.2022.2103804

Cited by 6 publications

(15 citation statements)

References 39 publications

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“…As with mycobacteria, cationic TMPyP4 proved to be more efficient as exogenous PS in PDI, providing a lower MIC value on A. baumannii than anionic TPPS and showing more promising antibiofilm activity [161]. With white light (380-700 nm; irradiance 40 W/m 2 ; light dose 64.8 J/cm 2 ), TMPyP4 at a concentration of 5 µM resulted in a >5-log reduction determined after 24 h against the MDR strain of A. baumanni in hospital wastewater, and similar results were obtained when this bacterium was in hospital wastewater present together with P. aeruginosa, S. aureus, and E. coli [162].…”

Section: Acinetobacter Baumanniimentioning

confidence: 99%

Photodynamic Inactivation of Opportunistic Premise Plumbing Pathogens and Their Biofilms

Mušković,

Gobin,

Malatesti

2023

Processes

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Opportunistic premise plumbing pathogens (OPPPs) form a group of microorganisms that normally live in water supply systems and have adapted especially well to the conditions in premise plumbing systems, and as such pose a threat to human health. Since the beginning of the 21st century, this threat has been escalating, and it is becoming increasingly evident that current water disinfection methods fall short in effectively controlling these pathogens. In researching new approaches to this emergency, phototherapy looks promising, especially one that combines photosensitizers, light, and oxygen, which is known as photodynamic inactivation (PDI). This review describes the main characteristics of the recognized (Pseudomonas aeruginosa, Legionella pneumophila, and Mycobacterium avium) and most important emerging OPPPs, and it offers a brief overview of current disinfection methods and their limitations in the fight against OPPPs. The principle and outcomes of PDI with endogenous and, in particular, exogenous photosensitizers are then explained and described through representative examples of PDI on recognized and emerging OPPPs and their biofilms. Finally, the prospects and future directions of PDI research in water disinfection and control of OPPPs are discussed.

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Section: Acinetobacter Baumanniimentioning

confidence: 99%

Photodynamic Inactivation of Opportunistic Premise Plumbing Pathogens and Their Biofilms

Mušković,

Gobin,

Malatesti

2023

Processes

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“…As a result, Gram-negative bacteria are resistant to neutral or anionic PS treatment. For example, Caprara et al demonstrated the high potency of the positively charged PS, meso-tetra(4-N-methyl-pyridyl)porphyrin (H 2 TMePyP + ) against Gram-negative Acinetobacter baumannii compared to the negatively charged PS, meso-tetra(4-sulfonate phenyl)porphyrin (H 2 TPPS − ) [15]. Positively charged PSs from tetra(4-pyridyl)porphyrin) cisplatin derivatives have also been reported to be efficient against Gram-positive and Gram-negative bacteria [16].…”

Section: Antimicrobial Photodynamic Therapymentioning

confidence: 99%

“…Radachlorin [22], protoporphyrin IX [23] and Methylene blue [23,24], riboflavin, chlorophyllin [25,26], Toluidine blue O combined with TiO 2 and ZnO nanoparticles [27], red-carbon dots [28], aloe-emodin [29], fotoenticine [30], erythrosine [31], Chlorin e6 and Perfluorodecalin nanoemulsion [32], meso-tetra(4-N-methyl-pyridyl)porphyrin [15], 5, 10, 15, 20-trakis(4-((s)-2, 6-diaminohexanamido)-phenyl) porphyrin [33], hypericin nanoparticles combined with D-Tryptophan [34].…”

Section: Acinetobacter Baumannii Gnmentioning

confidence: 99%

“…Due to their ability to interact with light and rate, these molecules can be photosensitizers in aPDT. Several fi inactivated using porphyrins as PSs in aPDT [15][16][17]35,[52][53][54][55][56][57][58] porphyrins are more active as PSs against Gram-positive and Gra anionic or non-ionic PSs. Work by Banfi et al showed that posi porphyrins are important for PS antibacterial activity [80], as the into the cell.…”

Section: Use Of Porphyrins As Pss Against Fish Bacterial Pathogensmentioning

confidence: 99%

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Applications of Antimicrobial Photodynamic Therapy in Aquaculture: Effect on Fish Pathogenic Bacteria

Dube,

Okuthe

2024

Fishes

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Increased infectious diseases and the reduced effectiveness of antibiotics due to antimicrobial resistance pose global challenges affecting the aquaculture industry. As bacteria increasingly develop antibiotic resistance, research scientists are shifting their focus to technologies such as antimicrobial photodynamic therapy (aPDT), which show potential for treating and controlling fish infections without promoting the development of resistant bacteria. Various photosensitizers (PSs), both natural and synthetic, are under investigation for their application in aPDT within the aquaculture industry. This shift is crucial for the sustainability of the aquaculture industry, which plays a significant role in achieving several of the United Nations (UN) Sustainable Development Goals (SDGs). This review highlights the application of aPDT against fish pathogens in the industry and the types of PSs utilized. It also explores the potential application of this technique for treating and controlling fish infections, along with the advantages and limitations of its use in aquaculture production systems. Finally, a conclusion and future perspectives are provided.

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“…The presence of a restriction enzyme in bacteria could play a vital role in cleaving the phosphodiester bonds of DNA molecules through the formation of hydrogen bonding between the hydrogen atom of water molecules and the oxygen atom of the phosphodiester bonds. Other studies, however, demonstrated that metalloporphyrins might also be used in photodynamic therapy (PDT) as antibacterial agents. − In a PDT system, light excites the porphyrins, which then generate free radicals, particularly reactive oxygen species, that cleave biomolecules, including DNA.…”

Section: Introductionmentioning

confidence: 99%

Interactions of Co(II)- and Zn(II)porphyrin of 5,10,15,20-tetrakis(1-methyl-4-pyridinio)porphyrin with DNA in Aqueous Solution and Their Antimicrobial Activities

Upoma,

Akter,

Ferdousi

et al. 2024

ACS Omega

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Antibiotics are frequently used to treat, prevent, or control bacterial infections, but in recent years, infections resistant to all known classes of conventional antibiotics have significantly grown. The development of novel, nontoxic, and nonincursive antimicrobial methods that work more quickly and efficiently than the present antibiotics is required to combat this growing public health issue. Here, Co(II) and Zn(II) derivatives of tetrakis(1-methylpyridinium-4yl)porphyrin [H 2 TMPyP] 4+ as a tetra(ρtoluenesulfonate) were synthesized and purified to investigate their interactions with DNA (pH 7.40, 25 °C) using UV−vis, fluorescence techniques, and antimicrobial activity. UV−vis results showed that [H 2 TMPyP] 4+ had a high hypochromicity (∼64%) and a substantial bathochromic shift (Δλ, 14 nm), while [Co(II)TMPyP] 4+ and [Zn(II)TMPyP] 4+ showed little hypochromicity (∼37%) and a small bathochromic shift (Δλ, 3−6 nm). Results reveal that [H 2 TMPyP] 4+ interacts with DNA via intercalation, while Co(II)-and [Zn(II)TMPyP] 4+ interact with DNA via outside self-stacking. Fluorescence results also confirmed the interaction of [H 2 TMPyP] 4+ and the metalloporphyrins with DNA. Results of the antimicrobial activity assay revealed that the metalloporphyrins showed inhibitory effects on Gram-positive and Gram-negative bacteria and fungi, but that neither the counterions nor [H 2 TMPyP] 4+ exhibited any inhibitory effects. Mechanism of antimicrobial activities of metalloporphyrins are discussed.

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Charge effect of water-soluble porphyrin derivatives as a prototype to fight infections caused by Acinetobacter baumannii by aPDT approaches

Cited by 6 publications

References 39 publications

Photodynamic Inactivation of Opportunistic Premise Plumbing Pathogens and Their Biofilms

Photodynamic Inactivation of Opportunistic Premise Plumbing Pathogens and Their Biofilms

Applications of Antimicrobial Photodynamic Therapy in Aquaculture: Effect on Fish Pathogenic Bacteria

Interactions of Co(II)- and Zn(II)porphyrin of 5,10,15,20-tetrakis(1-methyl-4-pyridinio)porphyrin with DNA in Aqueous Solution and Their Antimicrobial Activities

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