Charge Driven Fragmentation of Nucleobases

Abstract

We studied multiple ionization of single nucleobases by means of slow highly charged ions (Xe(q+), q=5-25). The products of the subsequent fragmentation were studied using high resolution coincidence time-of-flight spectrometry. We observed a strong dependence of the fragment kinetic energies on the initial charge state of the intermediate parent ions as well as on the initial chemical environment of the respective fragment ions within the parent molecule. The data allow us to shed light on the charge distribution within the molecule as well as on the fragmentation dynamics of these intermediate size systems.

Theoretical treatment of charge transfer in collisions ofC2+ions with HF: Anisotropic and vibrational effect

“…Effectively, important damage induced by the interaction of ionizing radiation with biological tissues is due to the secondary particles, low-energy electrons, radicals, or singly and multiply charged ions generated along the track after irradiation of the biological medium [10]. Experimental and theoretical studies have thus been developed on collisions between ions and molecular or even biomolecular targets [5][6][7][8][9][11][12][13][14] in order to understand the different mechanisms involved at the molecular level.…”

Multi-photon ionization and fragmentation of uracil: Neutral excited-state ring opening and hydration effects

“…Table I lists the peaks observed at 220 nm. Dissociative ionization of uracil has been studied extensively by electron impact, [23][24][25][26][27][28] ion impact, [28][29][30][31][32][33][34][35] and single photon absorption. 21 Taking into account differences in energy deposition and signal/noise ratios, the previous experiments were broadly consistent in terms of the fragment ions produced and three high-resolution examples are summarized in Table I.…”

Time-dependent density functional theory molecular dynamics simulation of doubly charged uracil in gas phase

“…effects of the chemical environment). The choice of uracil corresponds to the large tradition within the collisional physics community in which it has been chosen as a benchmark because of its biological relevance (RNA base) and high thermal stability [4,6,[23][24][25][26][27]. The paper has been divided as follows: Section 2 describes the theoretical methods used and also provides a brief survey of the proton collisional experiment, Section 3 discusses the main results and Section 4 summarizes the most important conclusions.…”

“…Early stages of damage after irradiation have been approached by collisions experiments of DNA and RNA building blocks in gas phase [4][5][6].…”