Charge-dependent regulation of NADPH oxidase activities in intact and subcellular systems of polymorphonuclear leukocytes

Miyahara, Masanobu; Okimasu, Eiji; Uchida, Hidetsugu; Sato, Eisuke F.; Yamamoto, Masazumi; Utsumi, Kozo

doi:10.1016/0167-4889(88)90160-7

Cited by 18 publications

(2 citation statements)

References 35 publications

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“…The incomplete protection of drugs in Group I indicates that their reactivities against peroxyl radicals are not so strong. However, the oxidative stress generated by the peroxyl radical production with the rate of 1.18X10-9 mol/min (2 ml) in our system is considered to be much more intense compared with physiological oxidative stress (27). We, therefore, speculate that these drugs may be efficacious as antioxidants even in vivo.…”

Section: Discussionmentioning

confidence: 81%

In vitro study on antioxidant potential of various drugs used in the perioperative period

Kang

Tsuchiya

Packer

et al. 1998

Acta Anaesthesiol Scand

101

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Section: Discussionmentioning

confidence: 81%

In vitro study on antioxidant potential of various drugs used in the perioperative period

Kang

Tsuchiya

Packer

et al. 1998

Acta Anaesthesiol Scand

101

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“…Such clastogenic factors have a longer half-life than free radicals, penetrate cell membranes, cause chromosomal damage, and may contribute to tumor promotion and progression (Cerutti, 1988;Cerutti and Trump, 1991). Interestingly, AA release and its role in the generation of ROS by NADPH oxidase do not always require PKC activation (Ohuchi et al, 1987;Fischer et al, 1988;Miyahara et at., 1988;Henderson et al, 1989;Marks et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

Ability of the non‐phorbol ester‐type tumor‐promoter thapsigargin to mimic the stimulatory effects of 12‐0‐tetradecanoylphorbol‐13‐acetate on ornithine decarboxylase activity, hydroperoxide production, and macromolecule synthesis in mouse epidermis In vivo

Perchellet¹,

Gali²,

Gao³

et al. 1993

Intl Journal of Cancer

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The biochemical effects of the non-12-0-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoter thapsigargin (TG), which does not bind to the phorbol-ester receptor, or activate protein kinase C (PKC) or increase inositol polyphosphates, were characterized in mouse epidermis in vivo. The cold scraping method is required to detect the induction of ornithine decarboxylase (ODC) activity by TG, a response much smaller than that caused by TPA and with a different time course. TG pre-treatments do not alter or cause a refractory state against ODC induction by TPA. But TG stimulates hydroperoxide (HPx) production and RNA, protein, and DNA synthesis almost as much as TPA. Moreover, the sequential effects of TG and TPA on DNA synthesis are identical: early inhibition at 8 hr followed by maximal stimulation at 16-32 hr. TG-stimulated HPx production requires protein synthesis and xanthine oxidase, phospholipase A2, and lipoxygenase activities but not RNA and DNA synthesis, and cyclooxygenase and protease activities. The HPx response to TG is not mimicked by the PKC activator prostratin or inhibited by pre-treatments with prostratin or specific PKC inhibitors. However, the Ca(2+)-ATPase inhibitor cyclopiazonic acid and the Ca2+ ionophore and weak ODC inducer A23187 mimic remarkably the HPx responses to TG and TPA. Since TG and A23187 are known to be, respectively, weak and incomplete tumor promoters as compared with TPA, the present results suggest that the HPx responses common to Ca(2+)-mobilizing and TPA- or non-TPA-type agents are insufficient to achieve tumor promotion in the absence of major ODC induction.

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Human neutrophils stimulated by cetyltrimethyl ammonium bromide generate luminol-amplified and non-amplified chemiluminescence but no superoxide production: A paradox

Ginsburg

Misgav

Samuni

et al. 1992

Inflammopharmacology

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Charge-dependent regulation of NADPH oxidase activities in intact and subcellular systems of polymorphonuclear leukocytes

Cited by 18 publications

References 35 publications

In vitro study on antioxidant potential of various drugs used in the perioperative period

In vitro study on antioxidant potential of various drugs used in the perioperative period

Ability of the non‐phorbol ester‐type tumor‐promoter thapsigargin to mimic the stimulatory effects of 12‐0‐tetradecanoylphorbol‐13‐acetate on ornithine decarboxylase activity, hydroperoxide production, and macromolecule synthesis in mouse epidermis In vivo

Human neutrophils stimulated by cetyltrimethyl ammonium bromide generate luminol-amplified and non-amplified chemiluminescence but no superoxide production: A paradox

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