Chardonnay grape seed procyanidin extract supplementation prevents high‐fat diet‐induced obesity in hamsters by improving adipokine imbalance and oxidative stress markers

Décordé, Kelly; Teissèdre, Pierre-Louis; Sutra, Thibault; Ventura, E.; Cristol, Jean‐Paul; Rouanet, Jean-Max

doi:10.1002/mnfr.200800165

Cited by 109 publications

(75 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Non flavonoids, highly abundant in grape skin, contain stilbenes such as resveratrol, which is at the basis of the french paradox (Renaud and De Lorgeril, 1992). GSSE has wide-ranging benefits including cardioprotective (Decordé et al, 2009), renoprotective (Safa et al, 2010), and neuroprotective (Wang et al, 2009) effects. GSSE also protects against hepatic ischemia-reperfusion injury (Sehirli et al, 2008), biliary obstruction (Dulundu et al, 2007), and azathioprineinduced hepatotoxicity in rats (El-Ashmawy et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat red blood cells and plasma

Hamlaoui

Mokni

Limam

et al. 2012

Bangladesh J Pharmacol

View full text Add to dashboard Cite

In this study, the protective role of grape seed and skin extract (GSSE) against doxorubicin-induced blood toxicity has been evaluated in rats. Rats were treated with the extract for 8 days and injected with doxorubicin (20 mg/kg) at the 4th day. At the end of the treatment, blood samples were collected for oxidative stress parameters determination and anti-oxidant enzymes. Doxorubicin increased erythrocytes and plasma malondialdehyde, free iron, H2O2 and carbonylation, decreased calcium and also decreased erythrocytes catalase, peroxidase and superoxide dismutase (specially the Fe isoform). Doxorubicin also decreased plasma catalase and superoxide dismutase (Cu/ Zn and Fe isoforms) but increased peroxidase. Doxorubicin increased plasma alanine aminotransferase and aspartate aminotransferase but decreased them within erythrocytes. GSSE co-treatment counteracted almost all deleterious effects induced by doxorubicin. In conclusion, doxorubicin induced a prooxidative stress into rat erythrocytes and plasma and GSSE exerted antioxidant properties which can be attributed to free iron and calcium modulation. Article Info

show abstract

Section: Introductionmentioning

confidence: 99%

Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat red blood cells and plasma

Hamlaoui

Mokni

Limam

et al. 2012

Bangladesh J Pharmacol

View full text Add to dashboard Cite

show abstract

“…Other studies have demonstrated the ability of specific botanical compounds to inhibit NADPH oxidase by directly binding to p47 phox (kaempferol) (106), or disrupting the binding of the proline rich region of p22 phox to the tandem SH3 domain of the cytosolic subunits (celastrol) (107). Some polyphenols also have been shown to modulate NADPH oxidase subunit expression (108). Clearly, further studies are necessary to test apocynin (and its metabolites), especially its long-term efficacy, and other NADPH oxidase inhibitors in a variety of animal models of neurodegenerative diseases, and to accumulate additional information about mechanisms of action.…”

Section: Perspectivementioning

confidence: 99%

The neuroprotective effects of apocynin

Simonyi¹

2012

Front Biosci

View full text Add to dashboard Cite

The recognition of health benefits of phytomedicines and herbal supplements lead to an increased interest to understand the cellular and molecular basis of their biological activities. Apocynin (4-hydroxy-3-methoxy-acetophenone) is a constituent of the Himalayan medicinal herb Picrorhiza kurroa which is regarded as an inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, a superoxide-producing enzyme. NADPH oxidase appears to be especially important in the modulation of redox-sensitive signaling pathways and also has been implicated in neuronal dysfunction and degeneration, and neuroinflammmation in diseases ranging from stroke, Alzheimer's and Parkinson's diseases to psychiatric disorders. In this review, we aim to give an overview of current literature on the neuroprotective effects of apocynin in the prevention and treatment of neurodegenerative disorders. Particular attention is given to in vivo studies. KeywordsApocynin; NADPH oxidase; NOX2; Neurodegeneration; Animal models; Review INTRODUCTIONApocynin (4-hydroxy-3-methoxy-acetophenone) was first isolated from Apocynum species. Two North American species of Apocynum, A. androsaemifolium and A. cannabinum, were widely used by Native American tribes as medicine (1). In addition, Apocynum venetum is used as a tea in north China and Japan and reported to have hepatoprotective effects (2). Apocynin may also be obtained from other plants, e.g. from the rhizome of Iris species.Apocynin was discovered during activity-guided isolation of immunomodulatory constituents from Picrorhiza kurroa, an endangered medicinal plant native to the mountains of India, Nepal, Tibet and Pakistan. Picrorhiza kurroa has been used to treat liver diseases, upper respiratory tract disorders, chronic diarrhea, scorpion sting and fever in the Ayurvedic system of medicine (3). In traditional Chinese medicine, Picrorhiza has been used to treat Send correspondence to: Agnes Simonyi, Department of Biochemistry, 117 Schweitzer Hall, University of Columbia, MO 65211, simonyia@missouri.edu. NIH Public Access Author ManuscriptFront Biosci (Elite Ed It is important to note that no adverse side effects of Picrorhiza extract/apocynin have been reported (3). Apocynin has a very good safety profile in animal studies as well (4), and several studies used long-term treatment without any signs of ill-health effects (see the studies with transgenic mice of Alzheimer's disease, for an example). Our recent study on the bioavailability of apocynin showed that apocynin is rapidly metabolized into glucuronic conjugate (5). At 30 min and 1 h after injection (5 mg/kg body wt, i.p.), approximately 50% of apocynin was converted to its glycosyl derivative and was distributed in plasma, liver and brain. Apocynin appeared in plasma as early as 30 min, peaked at 1 h and declined to low levels after 2 h (5). Following intragastric administration, apocynin is shown to undergo rapid absorption and excretion; with urinary excretion containing the unchanged form, the glucuronide, demethylat...

show abstract

“…Adiponectin level is also recorded to be lower in type-2 diabetes individuals and CVD patients [44]. It has been demonstrated that chronic consumption of grape phenols resulted in reduction of obesity and related metabolic pathways as well as increased production of adiponectin [45].…”

Section: Dietary Intervention To Reduce Adipose Tissue Inflammation Amentioning

confidence: 98%

Relationship between Common Dietary Polyphenols and Obesity-Induced Inflammation

Tucakovic¹,

Colson²,

Singh³

2015

fph

View full text Add to dashboard Cite

The incidence of obesity and its related metabolic disorders has escalated dramatically in the past decades worldwide. Defined as abnormal or excessive fat accumulation caused by an imbalance between energy intake and expenditure, obesity is presently the major health challenge in developed countries and the causative factor of numerous diseases such as heart problems, hypertension, hyperlipidemia and type 2 diabetes. Presence of high level of cytokines and acute phase proteins associated with inflammation in obese individuals relates obesity to chronic low-grade inflammation. Obesity-induced inflammation has an impact on insulin resistance and cardiac health. Polyphenols including catechins, tocopherols, resveratrol, curcumin and anthocyanins have been shown to reduce adipose tissue inflammation. It has been broadly accepted that adipocyte dysfunction plays a major role in development of obesity and obesity related complications. This state is characterised by hypersecretion of pro-atherogenic, pro-inflammatory and pro-diabetic adipokines as well as decreased secretion of adiponectin. The dietary polyphenols described in this review have potential as nutritional strategies for the prevention of obesity and associated inflammation as well as increase in insulin sensitivity in diabetic people.

show abstract

Chardonnay grape seed procyanidin extract supplementation prevents high‐fat diet‐induced obesity in hamsters by improving adipokine imbalance and oxidative stress markers

Cited by 109 publications

References 49 publications

Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat red blood cells and plasma

Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat red blood cells and plasma

The neuroprotective effects of apocynin

Relationship between Common Dietary Polyphenols and Obesity-Induced Inflammation

Contact Info

Product

Resources

About