Charcot–Leyden crystals associated with acute myeloid leukemia: Case report and literature review

Khrizman, Polina; Altman, Jessica K.; Mohtashamian, Arash; Peterson, LoAnn; Chen, Yihua; Tallman, Martin S.

doi:10.1016/j.leukres.2010.08.014

Cited by 9 publications

(11 citation statements)

References 8 publications

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“…The clinical symptoms could be very severe with fatigue, bone pains, fever and biological alterations as anemia, thrombocytopenia, leucopenia or leukocytosis, coagulopathy, high LDH level, and/or hypercalcemia [ 6 ]. The diagnosis is made by bone marrow aspirates or biopsy, with sometimes the presence of Charcot-Leyden crystals [ 27 ]. The treatment is based on the associated pathology.…”

Section: Introductionmentioning

confidence: 99%

Bone Marrow Necrosis in Newly Diagnosed Acute Leukemia: Two Case Reports and Review of the Literature

et al. 2017

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Bone marrow necrosis (BMN) in acute leukemia is a rare histopathological entity at the time of initial diagnosis. However, it represents an important diagnostic and prognostic challenge. Two cases of BMN are reported: a 44-year-old patient with B cell precursor (BCP) acute lymphoblastic leukemia (ALL) and a 27-year-old man with FAB-M5 acute myeloid leukemia (AML) who both presented with bone marrow failure and extensive necrosis. From these clinical cases, we conducted a brief review of the literature.

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Section: Introductionmentioning

confidence: 99%

Bone Marrow Necrosis in Newly Diagnosed Acute Leukemia: Two Case Reports and Review of the Literature

et al. 2017

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“…(Mondet et al, 2021). Furthermore Charcot-Leyden crystals ( CLC ) were found in the bone marrow of patients with AML (Khrizman et al, 2010; Radujkovic et al, 2011; Manny et al, 2012). The small nucleolar RNA host gene ( SNHG ) family members have been revealed to be oncogenes in several cancers (Zimta et al, 2020) and SNHG10 was found to be upregulated in AML patients (Xiao et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

TRAWLING: a Transcriptome Reference Aware of spLIciNG events

Nanni

Reyes

et al. 2021

Preprint

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Alternative splicing is critical for human gene expression regulation and plays an important role in multiple human diseases. In this context, RNA sequencing has emerged as powerful approach to detect alternative splicing events. In parallel, fast alignment-free methods have emerged as a viable alternative to quantify gene and transcript level abundance from RNAseq data. However, the ability to detect differential splicing events is dependent on the annotation of the transcript reference provided by the user. Here, we introduce a new reference transcriptome aware of splicing events, TRAWLING, which simplifies the detection of aberrant splicing events in a fast and simple way. In addition, we evaluate the performances and the benefits of aligning transcriptome data to TRAWLING using three different RNA sequencing datasets: whole transcriptome sequencing, single cell RNA sequencing and Digital RNA with pertUrbation of Genes. Collectively, our comprehensive evaluation underlines the value of using TRAWLING in transcriptomic data analysis.

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“…Disorders or pathological changes to bone marrow may cause massive proliferation of eosinophils and significant CLC formation. Recently, several independent case reports indicated that numerous CLCs are found in the bone marrow of patients with acute myeloid leukemia [ 100 , 101 , 102 , 103 ]. Moreover, in a patient with a FIP1L1-PDGFRA-positive myeloproliferative disorder, CLCs were seen in the areas with the highest concentrations of eosinophils in bone marrow [ 79 ].…”

Section: Relations Of Clc/gal-10 To Variable Diseasesmentioning

confidence: 99%

A Brief History of Charcot-Leyden Crystal Protein/Galectin-10 Research

2018

Molecules

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Eosinophils are present in tissues, such as the respiratory tract, spleen, lymph nodes and blood vessels. The significant presence of eosinophils in these tissues are associated with various diseases, including asthma, allergies, acute myeloid leukemia, etc. Charcot-Leyden crystal protein/galectin-10 is overexpressed in eosinophils and has also been identified in basophils and macrophages. In human body, this protein could spontaneously form Charcot-Leyden crystal in lymphocytes or in the lysates of lymphocytes. At present, the role of Charcot-Leyden crystal protein/galectin-10 in lymphocytes is not fully understood. This review summarizes research progress on Charcot-Leyden crystal protein/galectin-10, with emphasis on its history, cellular distributions, relations to diseases, structures and ligand binding specificity.

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Charcot–Leyden crystals associated with acute myeloid leukemia: Case report and literature review

Cited by 9 publications

References 8 publications

Bone Marrow Necrosis in Newly Diagnosed Acute Leukemia: Two Case Reports and Review of the Literature

Bone Marrow Necrosis in Newly Diagnosed Acute Leukemia: Two Case Reports and Review of the Literature

TRAWLING: a Transcriptome Reference Aware of spLIciNG events

A Brief History of Charcot-Leyden Crystal Protein/Galectin-10 Research

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