Abstract:IntroductionToothpaste has long been a part of our daily lives. In 500 BC, Indochina provided a recipe for a tooth-cleaning paste (1). Both France and the United States invented flexible lead or tin tubes in 1846, and toothpaste was first sold in bendable tubes in the US and Germany in 1896. In 1873, Colgate began manufacturing toothpaste in jars in the United States. The first fluoride toothpaste was introduced in the United States in 1955 (1).Toothpaste has always been offered to consumers as changing and de… Show more
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