Charakteristische Elektrolytveränderungen bei der erblichen Myopathie mit Kardiomyopathie des Syrischen Goldhamsters (Stamm BIO 8262)

Lossnitzer, K; Steinhardt, Bianca; Grewe, N; Stauch, M

doi:10.1007/bf01906382

Cited by 18 publications

(5 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the largest oxyfedrine dose i s fully effective in avoiding myocardial calcium accumulation, as the myocardial calcium content of untreated hamsters of a healthy strain and of similar age (23) resembles that gained by long-term treatment with the dose of 30 mg/kg oxyfedrine twice daffy. Furthermore, the largest oxyfedrine dose i s fully effective in avoiding myocardial calcium accumulation, as the myocardial calcium content of untreated hamsters of a healthy strain and of similar age (23) resembles that gained by long-term treatment with the dose of 30 mg/kg oxyfedrine twice daffy.…”

Section: Discussionmentioning

confidence: 95%

“…Details about the genetic background of the animals as well as the morphologic appearance of the heart and of biochemical and functional features are extensively reported elsewhere (30,29,19,22,23,41,24,25,26,31). Details about the genetic background of the animals as well as the morphologic appearance of the heart and of biochemical and functional features are extensively reported elsewhere (30,29,19,22,23,41,24,25,26,31).…”

Section: Ia Animalsmentioning

confidence: 99%

“…About the 40th day of life spontaneous and progressive myocardial necrotization in parallel with giant cell formation and increasing calcification-especially of these giant cells -is occurring, followed by resorptive changes and fibrosis (29). Biochemical analysis showed a tremendous increase in myocardial calcium content with increasing age of the animals (23).…”

Section: Ia Animalsmentioning

confidence: 99%

See 2 more Smart Citations

Cardioprotection by oxyfedrine in hereditary cardiomyopathic hamsters

et al. 1979

Self Cite

View full text Add to dashboard Cite

A defect of the myocardial plasma membrane, resulting in increased transmembrahe calcium conductivity with consecutive myocardial calcium accumulation and exhaustion of high energy phosphates is considered the determinant factor for cardiac degeneration in the dystrophic cardiomyopathy of Syrian hamsters from strain BIO 8262. Since oxyfedrine (L-3-[[~-hydroxy-a-methyl-phenethylamino]-3'methoxy-propiophenone hydrochloride), a drug against coronary heart disease, is described as a partial [3-adrenoceptor agonist ir~ducing moderate stimulation of 6adrenoceptors and simultaneously exerting an unspecific quinidine-like membrane effect on cardiac and smooth muscle, itwas of interest to investigate the action of this substance on the development of the hereditary hamster cardiomyopathy.Although during the prenecrotic stage of the disease only a very high acute dose of oxyfedrine (60 mg/kg s.c.) was able to distinctly counteract myocardial calcium accumulation induced by isoproterenol (1 mg/kg s.c.), chronical administration of low doses of oxyfedrine (twice daily 0.3 mg/kg s.c.) -as applied in humans -were able to considerably suppress spontaneous myocardial calcium accumulation. By chronical subcutaneous injection of 30 mg/kg oxyfedrine twice daily it was possible to avoid spontaneous myocardial calcium accumulation as well as to nearly prevent degeneration of the myocardium.These findings suggest that oxyfedrine exerts cardioprotection by its calcium antagonistic properties.The aminoketone derivative oxyfedrine (L-3-[~-hydroxy-a-methylphenethylamino]-3'-methoxy-propiophenone hydrochloride) is clinically used as a drug against coronary heart disease (42,39,36,15,44,13,27). Pharmacologically it is described as a partial ~-adrenoceptor agonist inducing simultaneous stimulation of ~-adrenoceptors and blockade of catecholamines at adequate concentrations and a quinidine-like effect on cardiac and smooth muscle at higher concentrations (14,2,38,28, 11). Its ~adrenoceptor stimulatory effect, however, is about ten times lower than that of adrenaline (11). 833

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Ia Animalsmentioning

confidence: 99%

Section: Ia Animalsmentioning

confidence: 99%

See 1 more Smart Citation

Cardioprotection by oxyfedrine in hereditary cardiomyopathic hamsters

et al. 1979

Self Cite

View full text Add to dashboard Cite

show abstract

“…2-(methylsulphonyl)ethanol 7a was prepared by oxidation of the corresponding thioalcohol by a modified procedure of Shim7. The following methylation procedure is described for compound (18) and has been used for all calcium antagonists.…”

Section: Nomentioning

confidence: 99%

“…Dihydropyridine monocarboxylic acids 12-15 were converted in-situ into their corresponding potassium salts 1611-19a followed by methylation with 11CH31 under phase transfer conditions to yield the products [16][17][18][19] in high purity and good chemical and radiochemical yields, scheme 4…”

Section: Introductionmentioning

confidence: 99%

Synthesis of carbon‐11 labelled calcium channel antagonists

Holschbach

Roden

Hamkens

1991

Labelled Comp Radiopharmac

View full text Add to dashboard Cite

A useful synthetic approach to carbon‐11 labelled 1,4‐dihydropyridines is described. Carbon‐11 labelled calcium channel antagonists 11C‐Nifedipine, 11C‐Nisoldipine, 11C‐Nitrendipine and 11C‐CF3‐Nifedipine were synthesized by a modified Hantzsch method using protected carboxy functions. Deprotection of the carboxylic acids by alkaline hydrolysis followed by conversion into the corresponding potassium salts and subsequent methylation with 11CH3I produced the labelled compounds in very good chemical and radiochemical yields (94%).

show abstract

Elements in muscle measured in vivo and in vitro with X‐ray spectrometry

Yarom¹,

Havivi²,

Notowitz³

et al. 1978

Muscle and Nerve

View full text Add to dashboard Cite

Calcium, iron, copper, and zinc concentrations in muscle were measured in vivo by x-ray spectrometry (XRS). The undersurface of the tongue was examined in cardiomyopathic and in normal hamsters. Values were compared to in-vitro analyses of various muscles from the same groups of animals using XRS and chemical analysis. Blood tests as well as histologic and histometric examinations were also performed. The correlated results show that XRS is a relatively sensitive and practical method for measuring chemical elements in muscle, and that it could be developed into a useful clinical test in certain neuromuscular and myocardial diseases. An interesting incidental finding was that, though all the examined muscles of myopathic animals had pathologic changes, only the tongue and myocardium, which are composed exclusively of red fibers, showed excessive calcium accumulation. This suggests either that the basic genetic aberration is not directly related to the oxidative metabolism, or that white muscles have a more efficient system for dealing with calcium overload.

show abstract

Charakteristische Elektrolytveränderungen bei der erblichen Myopathie mit Kardiomyopathie des Syrischen Goldhamsters (Stamm BIO 8262)

Cited by 18 publications

References 27 publications

Cardioprotection by oxyfedrine in hereditary cardiomyopathic hamsters

Cardioprotection by oxyfedrine in hereditary cardiomyopathic hamsters

Synthesis of carbon‐11 labelled calcium channel antagonists

Elements in muscle measured in vivo and in vitro with X‐ray spectrometry

Contact Info

Product

Resources

About