Characterizing the tissue dielectric constant of skin basal cell cancer lesions

Mayrovitz, Harvey N.; Gildenberg, Stuart; Spagna, Paige; Killpack, L.; Altman, David A.

doi:10.1111/srt.12585

Cited by 14 publications

(10 citation statements)

References 20 publications

(31 reference statements)

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“…These limitations motivate the development of systems capable of discriminating, directly in vivo, the significant dielectric variations of skin tissues associable to suspicious or malignant tumour cases at their very early stage, by comparing their dielectric response with reference healthy areas. Another limitation of the methods based on dielectric detection existing at the current state of the art relies to the analysis usually conducted at a single frequency [22]. As well known, the complex dielectric permittivity of biological tissues depends strongly on the frequency and, as a consequence, a single-frequency analysis can give a very limited information.…”

Section: Review Of the State Of The Art And Motivation Of The Present...mentioning

confidence: 99%

Microwave Reflectometry Sensing System For Low-Cost In-Vivo Skin Cancer Diagnostics

Schiavoni

Maietta

Filieri

et al. 2022

Preprint

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Skin cancer is one of the most commonly diffused cancer in the world and its incidence rates have constantly increased in recent years. At the current state of the art, there is a lack of objective, quick and non-invasive methods for diagnosing this condition; this, combined with hospital crowding, may lead to late diagnosis. Starting from these considerations, this paper addresses the implementation of a microwave reflectometry based-system that can be used as a non-invasive method for the in-vivo diagnosis and early detection of biological abnormalities, such as skin cancer. This system relies on the dielectric contrasts existing between normal and anomalous skin tissues at microwave frequencies. In particular, a truncated open-ended coaxial probe was designed, manufactured and tested to sense (in combination with a miniaturized Vector Network Analyzer) the variations of skin dielectric properties on a group of volunteer patients. The specific data processing demonstrated the suitability of the system for discriminating malignant and benign lesions from healthy skin, ensuring simultaneously effectiveness, low cost, compactness, comfortability and high sensitivity.

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Section: Review Of the State Of The Art And Motivation Of The Present...mentioning

confidence: 99%

Microwave Reflectometry Sensing System For Low-Cost In-Vivo Skin Cancer Diagnostics

Schiavoni

Maietta

Filieri

et al. 2022

Preprint

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Section: Dielectric Properties Of Skin Cancermentioning

confidence: 99%

“…Mayrovitz et al 57 performed an in vivo study at 300 MHz utilizing a simple hand‐held for measuring TDC which was performed in patients having skin BCC and in individuals with noncancerous lesions. This device would possibly characterize skin cancer lesions and noncancerous skin.…”

Section: Dielectric Properties Of Skin Cancermentioning

confidence: 99%

“…Determination of the tissue dielectric consistent (TDC) of tumor tissues as a way to recognize them from healthy or noncarcinogenic tissues has been a vital study of research that has focused on a lot of distinctive tumor sorts as in (Figure 3). 57 Aminzadeh et al 58 measured dielectric properties in the range of 20 to 100 GHz by applying the effective medium theory on normal and cancerous skin tissues. The complex permittivity of normal and malignant skin tissues was measured by utilizing the Bruggeman mixing model and dividing the tissues into two-phase, in the first one water is chosen as the fundamental constituent, Because of excessive water amount in skin and malignant lesions with circular incorporations made of dry biological components which were second phase.…”

Section: Dielectric Properties Of Skin Cancermentioning

confidence: 99%

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Dielectric spectroscopy signature for cancer diagnosis: A review

Fahmy

Hamad

Sayed

et al. 2020

Micro & Optical Tech Letters

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The effective clinical management of cancer is entirely dependent on the detection at a suitable early time as well as on the proper diagnosis. The main aim of this review is to survey the applications of dielectric spectroscopy in the clinical cancer diagnosis and distinguishing between normal and tumor tissues. This review focuses on the recognition of the biophysical properties of normal and malignant tissues and also of biophysical changes elicited by cancers comprising (breast, liver, thyroid gland, lung, skin, bladder, uterine and ovarian, lung, and prostate) tumors. These biophysical changes are often produced because of the difference in tissue composition, blood flow, and architecture between normal and malignant cells. From the literature, it has been observed that

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“…Beside healthcare assessment systems, skin impedance has been studied in multiple medical applications as an indicator for the functioning of the human body [1]. There is a wide spectrum of its utilization for cancer analysis [2], changes in the physiological state, virus detection [3], or sensation of fear [4]. Nowadays, bioimpedance is increasingly used to estimate the body composition [5,6] and to interpret the histological composition of different tissues [7].…”

Section: Introductionmentioning

confidence: 99%

Bioimpedance Sensor and Methodology for Acute Pain Monitoring

Ghita

Neckebroek

Juchem

et al. 2020

Sensors

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The paper aims to revive the interest in bioimpedance analysis for pain studies in communicating and non-communicating (anesthetized) individuals for monitoring purpose. The plea for exploitation of full potential offered by the complex (bio)impedance measurement is emphasized through theoretical and experimental analysis. A non-invasive, low-cost reliable sensor to measure skin impedance is designed with off-the-shelf components. This is a second generation prototype for pain detection, quantification, and modeling, with the objective to be used in fully anesthetized patients undergoing surgery. The 2D and 3D time–frequency, multi-frequency evaluation of impedance data is based on broadly available signal processing tools. Furthermore, fractional-order impedance models are implied to provide an indication of change in tissue dynamics correlated with absence/presence of nociceptor stimulation. The unique features of the proposed sensor enhancements are described and illustrated here based on mechanical and thermal tests and further reinforced with previous studies from our first generation prototype.

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Characterizing the tissue dielectric constant of skin basal cell cancer lesions

Cited by 14 publications

References 20 publications

Microwave Reflectometry Sensing System For Low-Cost In-Vivo Skin Cancer Diagnostics

Microwave Reflectometry Sensing System For Low-Cost In-Vivo Skin Cancer Diagnostics

Dielectric spectroscopy signature for cancer diagnosis: A review

Bioimpedance Sensor and Methodology for Acute Pain Monitoring

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