Characterizing the relationship between lesion-activation distance using fMRI and verbal measures in brain tumor patients

Riley, Sean P.; Chu, Daniel Y; Nair, Veena A.; Başkaya, Mustafa K.; Kuo, John S.; Meyerand, M. Elizabeth; Prabhakaran, Vivek

doi:10.1016/j.inat.2021.101391

Cited by 1 publication

(1 citation statement)

References 25 publications

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“…Lesion to activation distance has also been shown to be related to preoperative language performance. Riley and colleagues (2022) [45] examined the lesion to activation distance between fMRI activations in Broca's and Wernicke's area to the tumor location in relation to the verbal fluency performance. Individuals with lesion to activation distances of less than 10 mm to either Broca's area or Wernicke's area had significantly poorer verbal fluency performance than those with lesions greater than 10 mm from these primary language areas.…”

Section: Lesion To Activation Distancementioning

confidence: 99%

Beyond Broca’s and Wernicke’s: Functional Mapping of Ancillary Language Centers Prior to Brain Tumor Surgery

2023

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Functional MRI is a well-established tool used for pre-surgical planning to help the neurosurgeon have a roadmap of critical functional areas that should be avoided, if possible, during surgery to minimize morbidity for patients with brain tumors (though this also has applications for surgical resection of epileptogenic tissue and vascular lesions). This article reviews the locations of secondary language centers within the brain along with imaging findings to help improve our confidence in our knowledge on language lateralization. Brief overviews of these language centers and their contributions to the language networks will be discussed. These language centers include primary language centers of “Broca’s Area” and “Wernicke’s Area”. However, there are multiple secondary language centers such as the dorsal lateral prefrontal cortex (DLPFC), frontal eye fields, pre- supplemental motor area (pre-SMA), Basal Temporal Language Area (BTLA), along with other areas of activation. Knowing these foci helps to increase self-assurance when discussing the nature of laterality with the neurosurgeon. By knowing secondary language centers for language lateralization, via fMRI, one can feel confident on providing neurosurgeon colleagues with appropriate information on the laterality of language in preparation for surgery.

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Section: Lesion To Activation Distancementioning

confidence: 99%