Characterizing the phenomenon of radiation recall dermatitis

Camidge, Ross; Price, Allan

doi:10.1016/s0167-8140(01)00328-0

Cited by 254 publications

(384 citation statements)

References 37 publications

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“…9 The reaction often manifests as a dermatitis and can include maculopapular eruptions, vesicle formation, and skin desquamation. Internal organs and muscle are less commonly affected.…”

Section: Literature Review and Discussionmentioning

confidence: 99%

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Gemcitabine‐related radiation recall preferentially involves internal tissue and organs

Friedlander

Bansal

Schwartz

et al. 2004

Cancer

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Radiation recall refers to inflammatory reactions triggered by cytotoxic agents and develops in previously irradiated areas. Most reactions develop cutaneously. The most common chemotherapeutic agents implicated are anthracyclines and taxanes. Gemcitabine, a nucleotide analog, recently was implicated in several cases.The authors performed a literature search using PubMed and the search terms "gemcitabine" and "radiation recall" to find prior cases of radiation recall attributed to gemcitabine. These cases were compared with those attributed to anthracyclines and taxanes. The literature search found 12 cases of radiation recall caused by gemcitabine. The authors also determined that their case of myositis developing in the rectus abdominus muscle of a patient with pancreatic adenocarcinoma was the manifestation of radiation recall, thereby bringing the number of patients who developed radiation recall to gemcitabine and were discussed in the current study to 13. Approximately 70% of the cases manifested as inflammation of internal organs or tissues and 30% manifested as a dermatitis or mucositis. This finding differs from other common agents, in which 63% of the radiation recall events are reported to manifest as a dermatitis. Compared with anthracyclines and taxanes, the interval from the completion of radiation therapy to the initiation of chemotherapy is less for gemcitabine (median time of 56 days for gemcitabine, compared with 218 days for the taxanes and 646 days for doxorubicin). The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs. In contrast, other common agents for the most part trigger cutaneous inflammation. The development of internal tissue inflammation is reportedly correlated with a shorter interval from the time of completion of radiation therapy to the initiation of chemotherapy.

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“…9 The reaction often manifests as a dermatitis and can include maculopapular eruptions, vesicle formation, and skin desquamation. Internal organs and muscle are less commonly affected.…”

Section: Literature Review and Discussionmentioning

confidence: 99%

“…9 The reaction typically develops hours to days after the administration of the instigating agent but could occur after weeks of treatment.…”

Section: Manifestations Of Radiation Recall Reactions Attributed To Gmentioning

confidence: 99%

Gemcitabine‐related radiation recall preferentially involves internal tissue and organs

Friedlander

Bansal

Schwartz

et al. 2004

Cancer

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“…It can occur weeks to years after radiation therapy. 1 Dermatitis is the most frequently described inflammatory reaction. Although generally mild, in a review of 37 cases by Camidge and Price, 1 25% of patients had severe skin reactions develop.…”

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confidence: 99%

A case of radiation recall mucositis associated with docetaxel

et al. 2004

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Background. Radiation recall reactions, in particular dermatitis, are well documented in the literature. However, radiation recall mucositis is a rare clinical phenomenon.Methods. We report a case of a 45-year-old man diagnosed with squamous cell carcinoma of the base of tongue. He was treated with surgery followed by chemotherapy and radiation therapy. Several months after completing treatment, he had a recurrence develop outside of the previously irradiated field. He was offered radiation therapy concurrent with docetaxel as salvage therapy.Results. During salvage therapy, acute recall mucositis developed corresponding to his previously irradiated fields. His chemotherapy with docetaxel was withheld, and his symptoms rapidly improved.Conclusions. This case describes radiation recall mucositis associated with docetaxel, a rare but potentially serious clinical situation. Given the potential severity of the reaction and increasing use of docetaxel as second-line treatment of recurrent head and neck cancers, it is important to be aware of this phenomenon. B

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“…Although the exact pathogenesis of radiation recall reactions is not known, the condition is believed to be best explained by the mechanism of idiosyncratic drug hypersensitivity reaction 13,14 . Such reactions are likely not linked to the immune system; the suggestion is that certain drugs trigger non-immune inflammatory pathways in patients whose inflammatory response threshold has been lowered by radiation.…”

Section: Discussionmentioning

confidence: 99%

“…The first case described involved the antitumour antibiotic actinomycin D. However, recall reaction also occurs with other classes of chemotherapy agents, including anthracyclines (doxorubicin), alkylating agents (cyclophosphamide), antimetabolites (methotrexate), nucleoside analogs (gemcitabine), and taxanes 13,14 . It has also occurred with other classes of drugs including tamoxifen, simvastatin, and the anti-tuberculosis drugs (isoniazid, rifampicin, pyrazinamide) [7][8][9]22,23 .…”

Section: Discussionmentioning

confidence: 99%

Radiation Recall Dermatitis with Azithromycin

Vujovic

2010

Current Oncology

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Radiation recall is a well-known phenomenon that involves the "recall" of an acute inflammatory reaction in a previously irradiated region after administration of certain drugs. The most common type of radiation recall is radiation recall dermatitis, which involves the reoccurrence of an acute inflammatory skin reaction in previously irradiated skin. Most radiation recall reactions are attributable to chemotherapeutic agents. One previously reported case of radiation recall dermatitis occurred after administration of an antibiotic. The present case report is the second of radiation recall dermatitis involving an antibiotic: azithromycin.

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Characterizing the phenomenon of radiation recall dermatitis

Cited by 254 publications

References 37 publications

Gemcitabine‐related radiation recall preferentially involves internal tissue and organs

Gemcitabine‐related radiation recall preferentially involves internal tissue and organs

A case of radiation recall mucositis associated with docetaxel

Radiation Recall Dermatitis with Azithromycin

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