Characterizing the gut microbiome changes with aging in a novel Alzheimer’s disease rat model

Nagarajan, Akash; Srivastava, Hemant; Morrow, Casey D.; Sun, Liou Y.

doi:10.18632/aging.204484

Cited by 11 publications

(13 citation statements)

References 45 publications

(60 reference statements)

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“…We detected several bacterial taxa changes due to Diet at 1 week and 18 weeks but surprisingly not at 57 weeks. In our current study, we found alpha diversity metrics decreased with age, similar to our earlier published report where we saw alpha diversity decrease with age in Fischer344 rats (Nagarajan et al., 2023 ). However, others investigating the mouse microbiome did not report any changes in diversity with age (Binyamin et al., 2020 ).…”

Section: Discussionsupporting

confidence: 92%

“…This is further evidence that the gut microbiota changes significantly with age. The F/B ratio did not differ with age in our current study or our previous study with F344 rats (Nagarajan et al, 2023). The work of Binyamin and colleagues conflicts with ours, however, as they have reported an increased F/B ratio with advanced age (Binyamin et al, 2020).…”

Section: Discussioncontrasting

confidence: 78%

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Long term methionine restriction: Influence on gut microbiome and metabolic characteristics

Nagarajan,

Lasher,

Morrow

et al. 2024

Aging Cell

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The Methionine restriction (MR) diet has been shown to delay aging and extend lifespan in various model organisms. However, the long‐term effects of MR diet on the gut microbiome composition remain unclear. To study this, male mice were started on MR and control diet regimens at 6 months and continued until 22 months of age. MR mice have reduced body weight, fat mass percentage, and bone mineral density while having increased lean mass percentage. MR mice also have increased insulin sensitivity along with increasing indirect calorimetry markers such as energy expenditure, oxygen consumption, carbon dioxide production, and glucose oxidation. Fecal samples were collected at 1 week, 18 weeks, and 57 weeks after the diet onset for 16S rRNA amplicon sequencing to study the gut microbiome composition. Alpha and beta diversity metrics detected changes occurring due to the timepoint variable, but no changes were detected due to the diet variable. The results from LEfSe analysis surprisingly showed that more bacterial taxa changes were linked to age rather than diet. Interestingly, we found that the long‐term MR diet feeding induced smaller changes compared to short‐term feeding. Specific taxa changes due to the diet were observed at the 1 or 18‐week time points, including Ileibacterium, Odoribacter, Lachnoclostridium, Marinifilaceae, and Lactobacillaceae. Furthermore, there were consistent aging‐associated changes across both groups, with an increase in Ileibacterium and Erysipelotrichaceae with age, while Eubacterium_coprostanoligenes_group, Ruminococcaceae, Peptococcaceae, and Peptococcus decreased with age.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 78%

Long term methionine restriction: Influence on gut microbiome and metabolic characteristics

Nagarajan,

Lasher,

Morrow

et al. 2024

Aging Cell

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“…Studies in recent years have shown that bacteria produce a number of compounds that cause the development of systemic inflammatory responses that impair the blood–brain barrier (BBB), exacerbating neuroinflammation and ultimately neurodegeneration [ 79 , 80 , 81 ]. The microbiota produces a number of neuromediators such as serotonin, kynurenine, melatonin, GABA (gamma-aminobutyric acid), tryptophan, catecholamines, histamine and acetylcholine [ 82 , 83 ].…”

Section: Oral Microbiome In Systemic Diseasesmentioning

confidence: 99%

The Role of the Oral Microbiome in the Development of Diseases

Kozak

Pawlik

2023

IJMS

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Periodontal disease (PD) is a complex and infectious illness that begins with a disruption of bacterial homeostasis. This disease induces a host inflammatory response, leading to damage of the soft and connective tooth-supporting tissues. Moreover, in advanced cases, it can contribute to tooth loss. The aetiological factors of PDs have been widely researched, but the pathogenesis of PD has still not been totally clarified. There are a number of factors that have an effect on the aetiology and pathogenesis of PD. It is purported that microbiological, genetic susceptibility and lifestyle can determine the development and severity of the disease. The human body’s defence response to the accumulation of plaque and its enzymes is known to be a major factor for PD. The oral cavity is colonised by a characteristic and complex microbiota that grows as diverse biofilms on all mucosal and dental surfaces. The aim of this review was to provide the latest updates in the literature regarding still-existing problems with PD and to highlight the role of the oral microbiome in periodontal health and disease. Better awareness and knowledge of the causes of dysbiosis, environmental risk factors and periodontal therapy can reduce the growing worldwide prevalence of PDs. The promotion of good oral hygiene, limiting smoking, alcohol consumption and exposure to stress and comprehensive treatment to decrease the pathogenicity of oral biofilm can help reduce PD as well as other diseases. Evidence linking disorders of the oral microbiome to various systemic diseases has increased the understanding of the importance of the oral microbiome in regulating many processes in the human body and, thus, its impact on the development of many diseases.

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“…The development of Alzheimer’s disease [ 69 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 ] and the mechanisms through which the microbiome can contribute to the progression of Alzheimer’s disease have been investigated [ 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 ]. Numerous studies are also available regarding treatments with probiotics […”

Section: Discussionmentioning

confidence: 99%

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

Fekete,

Lehoczki,

Major

et al. 2024

Nutrients

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Recent research exploring the relationship between the gut and the brain suggests that the condition of the gut microbiota can influence cognitive health. A well-balanced gut microbiota may help reduce inflammation, which is linked to neurodegenerative conditions. Prebiotics, probiotics, and symbiotics are nutritional supplements and functional food components associated with gastrointestinal well-being. The bidirectional communication of the gut–brain axis is essential for maintaining homeostasis, with pre-, pro-, and symbiotics potentially affecting various cognitive functions such as attention, perception, and memory. Numerous studies have consistently shown that incorporating pre-, pro-, and symbiotics into a healthy diet can lead to improvements in cognitive functions and mood. Maintaining a healthy gut microbiota can support optimal cognitive function, which is crucial for disease prevention in our fast-paced, Westernized society. Our results indicate cognitive benefits in healthy older individuals with probiotic supplementation but not in healthy older individuals who have good and adequate levels of physical activity. Additionally, it appears that there are cognitive benefits in patients with mild cognitive impairment and Alzheimer’s disease, while mixed results seem to arise in younger and healthier individuals. However, it is important to acknowledge that individual responses may vary, and the use of these dietary supplements should be tailored to each individual’s unique health circumstances and needs.

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Characterizing the gut microbiome changes with aging in a novel Alzheimer’s disease rat model

Cited by 11 publications

References 45 publications

Long term methionine restriction: Influence on gut microbiome and metabolic characteristics

Long term methionine restriction: Influence on gut microbiome and metabolic characteristics

The Role of the Oral Microbiome in the Development of Diseases

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

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