Characterizing the Effects of Solvent and Analyte Properties on Ionization Efficiency by Novel Field-free and Field-enabled Ionization Techniques

Jayasundara, Kinkini

doi:10.33915/etd.11620

Cited by 1 publication

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“…While there are many unique forward looking contributions by groups such as Li, 112 Kostiainen, 204 Allen, 205 Kim, 206 Rybkin, 207 Clench, 155 Chow, 208 Wilkins, 209 Chakrabarty, 210 Pan, 211 Wang, 212 Valentine, [213][214][215] Yu, 216 and Bouza, 217 we will emphasize the utility of the new ionization processes for direct ionization MS as in: (a) a "pen"…”

Section: Unprecedented Applications Of Evaporation/sublimation-driven...mentioning

confidence: 99%

Direct sub‐atmospheric pressure ionization mass spectrometry: Evaporation/sublimation‐driven ionization is amazing, fundamentally, and practically

Trimpin,

Inutan,

Pagnotti

et al. 2024

J Mass Spectrom

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This paper covers direct sub‐atmospheric pressure ionization mass spectrometry (MS). The discovery, applications, and mechanistic aspects of novel ionization processes for use in MS that are not based on the high‐energy input from voltage, laser, and/or high temperature but on sublimation/evaporation within a region linking a higher to lower pressure and modulated by heat and collisions, are discussed, including how this new reality has guided a series of discoveries, instrument developments, and commercialization. A research focus, inter alia, is on how best to understand, improve, and use these novel ionization processes, which convert volatile and nonvolatile compounds from solids (sublimation) or liquids (evaporation) into gas‐phase ions for analysis by MS providing reproducible, accurate, sensitive, and prompt results. Our perception on how these unprecedented versus traditional ionization processes/methods relate to each other, how they can be made to coexist on the same mass spectrometer, and an outlook on new and expanded applications (e.g., clinical, portable, fast, safe, and autonomous) is presented, and is based on ST's Opening lecture presentation at the Nordic Mass spectrometry Conference, Geilo, Norway, January 2023. Focus will be on matrix‐assisted ionization (MAI) and solvent‐assisted ionization (SAI) MS covering the period from 2010 to 2023; a potential paradigm shift in the making.

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Section: Unprecedented Applications Of Evaporation/sublimation-driven...mentioning

confidence: 99%

Direct sub‐atmospheric pressure ionization mass spectrometry: Evaporation/sublimation‐driven ionization is amazing, fundamentally, and practically

Trimpin,

Inutan,

Pagnotti

et al. 2024

J Mass Spectrom

View full text Add to dashboard Cite

show abstract

Characterizing the Effects of Solvent and Analyte Properties on Ionization Efficiency by Novel Field-free and Field-enabled Ionization Techniques

Cited by 1 publication

References 0 publications

Direct sub‐atmospheric pressure ionization mass spectrometry: Evaporation/sublimation‐driven ionization is amazing, fundamentally, and practically

Direct sub‐atmospheric pressure ionization mass spectrometry: Evaporation/sublimation‐driven ionization is amazing, fundamentally, and practically

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