Characterizing the contrast of white matter and grey matter in high-resolution phase difference enhanced imaging of human brain at 3.0 T

Yang, Li; Wang, Shanshan; Yao, Bin; Li, Lili; Xu, Xiaofei; Guo, Lingfei; Zhao, Lianxin; Zhang, Sheng; Chen, Weibo; Chan, Queenie; Wang, Guangbin

doi:10.1007/s00330-014-3480-7

Cited by 4 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PADRE is a new phase-related imaging technique that can utilize any phase derived from both paramagnetic and diamagnetic substances. Previous studies of PADRE reported clear demonstration of normal structures, such as small fiber tracts of the brain stem ( 13 ), layers of the optic radiation, the stria of Gennari ( 16 , 17 ), gray-to-white matter interface or SWM ( 17 – 19 ) and the internal structures of the thalamus ( 14 ) with TEI. In addition, the relevance of PADRE findings to aging ( 49 ) and various pathological conditions including multiple system atrophy of the cerebellar type ( 13 ), Parkinson's disease ( 50 , 51 ), amyotrophic lateral sclerosis ( 15 ), multiple sclerosis ( 52 ) and Alzheimer's disease ( 53 ) has also been reported.…”

Section: Discussionmentioning

confidence: 99%

Differentiation of Brain Metastases and Gliomas Based on Color Map of Phase Difference Enhanced Imaging

et al. 2018

View full text Add to dashboard Cite

Background and objective: Phase difference enhanced imaging (PADRE), a new phase-related MRI technique, can enhance both paramagnetic and diamagnetic substances, and select which phases to be enhanced. Utilizing these characteristics, we developed color map of PADRE (Color PADRE), which enables simultaneous visualization of myelin-rich structures and veins. Our aim was to determine whether Color PADRE is sufficient to delineate the characteristics of non-gadolinium-enhancing T2-hyperintense regions related with metastatic tumors (MTs), diffuse astrocytomas (DAs) and glioblastomas (GBs), and whether it can contribute to the differentiation of MTs from GBs.Methods: Color PADRE images of 11 patients with MTs, nine with DAs and 17 with GBs were created by combining tissue-enhanced, vessel-enhanced and magnitude images of PADRE, and then retrospectively reviewed. First, predominant visibility of superficial white matter and deep medullary veins within non-gadolinium-enhancing T2-hyperintense regions were compared among the three groups. Then, the discriminatory power to differentiate MTs from GBs was assessed using receiver operating characteristic analysis.Results: The degree of visibility of superficial white matter was significantly better in MTs than in GBs (p = 0.017), better in GBs than in DAs (p = 0.014), and better in MTs than in DAs (p = 0.0021). On the contrary, the difference in the visibility of deep medullary veins was not significant (p = 0.065). The area under the receiver operating characteristic curve to discriminate MTs from GBs was 0.76 with a sensitivity of 80% and specificity of 64%.Conclusion: Visibility of superficial white matter on Color PADRE reflects inferred differences in the proportion of vasogenic edema and tumoral infiltration within non-gadolinium-enhancing T2-hyperintense regions of MTs, DAs and GBs. Evaluation of peritumoral areas on Color PADRE can help to distinguish MTs from GBs.

show abstract

Section: Discussionmentioning

confidence: 99%

Differentiation of Brain Metastases and Gliomas Based on Color Map of Phase Difference Enhanced Imaging

et al. 2018

View full text Add to dashboard Cite

show abstract

“…A new phase-weighted MRI technique, phase difference-enhanced imaging (PADRE), uses the phase difference between the target and surrounding tissue to enhance the contrast of the target tissue. 10 , 11 Choosing the appropriate phase differences allows the variation in tissue contrast using single imaged magnetic resonance (MR) data. Some PADRE images yield a level of contrast that could not be realized with earlier phase techniques.…”

Section: Introductionmentioning

confidence: 99%

Juxtacortical Lesions in Multiple Sclerosis: Assessment of Gray Matter Involvement Using Phase Difference-enhanced Imaging (PADRE)

et al. 2016

View full text Add to dashboard Cite

Purpose:In multiple sclerosis (MS), a juxtacortical lesion at the border between the gray matter (GM) and subcortical white matter (WM) may often involve the GM. A recently developed, phase-weighted magnetic resonance imaging (MRI) technique “phase difference enhanced imaging (PADRE)” can delineate the GM and WM clearly due to the difference in myelin concentration. We evaluated whether PADRE is useful for the detection of GM involvement in the juxtacortical MS lesions.Methods:One neuroradiologist reviewed the conventional MRI in 13 MS patients and selected 48 juxtacortical lesions. At the first reading session with the conventional MRI alone (T2-weighted imaging, and two-dimensional and three-dimensional fluid-attenuated inversion recovery), two other neuroradiologists classified the lesions into three patterns according to their anatomical locations: (a) subcortical WM lesions involving the subcortical WM alone; (b) intracortical (IC) lesions involving the GM alone; (c) mixed GM/subcortical WM (mixed) lesions involving the both subcortical WM and GM. We defined the subcortical WM as a WM within a distance of 10 mm from inner edge of the GM. For the analyses, we excluded the white matter lesions further than 10 mm from inner edge of the GM. At the second reading session MRI and PADRE were available and the radiologists re-evaluated their prior classification.Results:At the first reading session, 27 lesions were classified as (a), 1 as (b), and 20 as (c). Therefore, a total of 21 lesions (44%) were judged to involve the GM. At the second reading session, the classification of 15 (31%) lesions changed; all 15 lesions were judged to involve the GM on the PADRE. Interobserver agreement (kappa value) was 0.84 for the first- and 0.95 for the second reading session.Conclusion:PADRE is useful for detecting GM involvement of the juxtacortical MS lesions.

show abstract

Delineation of the nerve fiber bundles of the infant brain associated with aging using phase difference-enhanced imaging: a preliminary study

et al. 2020

View full text Add to dashboard Cite

Characterizing the contrast of white matter and grey matter in high-resolution phase difference enhanced imaging of human brain at 3.0 T

Cited by 4 publications

References 37 publications

Differentiation of Brain Metastases and Gliomas Based on Color Map of Phase Difference Enhanced Imaging

Differentiation of Brain Metastases and Gliomas Based on Color Map of Phase Difference Enhanced Imaging

Juxtacortical Lesions in Multiple Sclerosis: Assessment of Gray Matter Involvement Using Phase Difference-enhanced Imaging (PADRE)

Delineation of the nerve fiber bundles of the infant brain associated with aging using phase difference-enhanced imaging: a preliminary study

Contact Info

Product

Resources

About