Characterizing Strategy Use During the Performance of Hippocampal-Dependent Tasks

Clark, Ian A.; Monk, Anna M.; Maguire, Eleanor A.

doi:10.3389/fpsyg.2020.02119

Cited by 17 publications

(16 citation statements)

References 61 publications

(106 reference statements)

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“…(2019) recently reported that the ability to construct scene imagery explained the relationships between episodic memory, imagining the future and spatial navigation task performance. The prominence of scenes was further emphasised in another study involving the same sample, where the explicit strategies people used to perform episodic memory recall, future thinking and spatial navigation tasks was assessed ( Clark, Monk, & Maguire, 2020 ). In each case, the use of scene visual imagery strategies was significantly higher than for all other types of strategies (see also Andrews-Hanna, Reidler, Sepulcre, Poulin, & Buckner, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

Characterising the hippocampal response to perception, construction and complexity

McCormick

Dalton

Zeidman

et al. 2021

Cortex

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The precise role played by the hippocampus in supporting cognitive functions such as episodic memory and future thinking is debated, but there is general agreement that it involves constructing representations comprised of numerous elements. Visual scenes have been deployed extensively in cognitive neuroscience because they are paradigmatic multi-element stimuli. However, questions remain about the specificity and nature of the hippocampal response to scenes. Here, we devised a paradigm in which we had participants search pairs of images for either colour or layout differences, thought to be associated with perceptual or spatial constructive processes respectively. Importantly, images depicted either naturalistic scenes or phase-scrambled versions of the same scenes, and were either simple or complex. Using this paradigm during functional MRI scanning, we addressed three questions: 1. Is the hippocampus recruited specifically during scene processing? 2. If the hippocampus is more active in response to scenes, does searching for colour or layout differences influence its activation? 3. Does the complexity of the scenes affect its response? We found that, compared to phase-scrambled versions of the scenes, the hippocampus was more responsive to scene stimuli. Moreover, a clear anatomical distinction was evident, with colour detection in scenes engaging the posterior hippocampus whereas layout detection in scenes recruited the anterior hippocampus. The complexity of the scenes did not influence hippocampal activity. These findings seem to align with perspectives that propose the hippocampus is especially attuned to scenes, and its involvement occurs irrespective of the cognitive process or the complexity of the scenes.

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Section: Discussionmentioning

confidence: 99%

Characterising the hippocampal response to perception, construction and complexity

McCormick

Dalton

Zeidman

et al. 2021

Cortex

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“…In support of this idea, a recent individual differences study involving a large sample of participants ( n = 217), found that the ability to construct scene imagery fully mediated the relationships between autobiographical memory recall and other hippocampal‐dependent functions such as future thinking and spatial navigation (Clark et al, 2019). Moreover, in the same sample, strategies involving scene imagery predominated when recollecting autobiographical memories (Clark, Monk, & Maguire, 2020). It is also notable that the volume of the pre/parasubiculum is of particular clinical importance as a diagnostic marker.…”

Section: Discussionmentioning

confidence: 99%

The relationship between hippocampal subfield volumes and autobiographical memory persistence

2020

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“…Scene imagery features prominently when we recall autobiographical memories, imagine the future and navigate around in the world ( Clark et al, 2020 ). Consequently, in this study we sought to better understand how scene representations are supported by the brain.…”

Section: Discussionmentioning

confidence: 99%

“…The vmPFC has strong anatomical and functional connections with the hippocampus and lateral temporal cortex ( Andrews-Hanna et al, 2010 ; Catani et al, 2012 ). Together, these structures are often co-activated during fMRI studies involving scene processing ( Zeidman et al, 2015 ; McCormick et al, 2021 ), and tasks that are known to involve scene imagery ( Clark et al, 2020 ) such as autobiographical memory recall, future thinking and spatial navigation ( Svoboda et al, 2006 ; Spreng et al, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

The distinct and overlapping brain networks supporting semantic and spatial constructive scene processing

McCormick

Maguire

2021

Neuropsychologia

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Scene imagery features prominently when we recall autobiographical memories, imagine the future and navigate around in the world. Consequently, in this study we sought to better understand how scene representations are supported by the brain. Processing scenes involves a variety of cognitive processes that in the real world are highly interactive. Here, however, our goal was to separate semantic and spatial constructive scene processes in order to identify the brain areas that were distinct to each process, those they had in common, and the connectivity between regions. To this end, participants searched for either semantic or spatial constructive impossibilities in scenes during functional MRI. We focussed our analyses on only those scenes that were possible, thus removing any error detection that would evoke reactions such as surprise or novelty. Importantly, we also counterbalanced possible scenes across participants, enabling us to examine brain activity and connectivity for the same possible scene images under two different conditions. We found that participants adopted different cognitive strategies, which were reflected in distinct oculomotor behaviour, for each condition. These were in turn associated with increased engagement of lateral temporal and parietal cortices for semantic scene processing, the hippocampus for spatial constructive scene processing, and increased activation of the ventromedial prefrontal cortex (vmPFC) that was common to both. Connectivity analyses showed that the vmPFC switched between semantic and spatial constructive brain networks depending on the task at hand. These findings further highlight the well-known semantic functions of lateral temporal areas, while providing additional support for the previously-asserted contribution of the hippocampus to scene construction, and recent suggestions that the vmPFC may play a key role in orchestrating scene processing.

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Characterizing Strategy Use During the Performance of Hippocampal-Dependent Tasks

Cited by 17 publications

References 61 publications

Characterising the hippocampal response to perception, construction and complexity

Characterising the hippocampal response to perception, construction and complexity

The relationship between hippocampal subfield volumes and autobiographical memory persistence

The distinct and overlapping brain networks supporting semantic and spatial constructive scene processing

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