Characterizing poroelasticity of biological tissues by spherical indentation: An improved theory for large relaxation

Wang, Ming; Liu, Shaobao; Xu, Zhengyi; Qu, Kai; Li, Moxiao; Chen, Xin; Xue, Qi‐Kun; Genin, Guy M.; Lu, Tian Jian; Xu, Feng

doi:10.1016/j.jmps.2020.103920

Cited by 28 publications

(14 citation statements)

References 76 publications

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“…The assumption of incompressibility for hydrated materials is only justified if the interstitial fluid (IF) is bound to the tissue matrix or the specimen is entirely confined during loading. Brown et al [41] demonstrated that under unconfined loading, the sclera tissue behaves like poroelastic material; a similar result was also observed by Wang et al [42] for the skin tissue. Some other studies have reported the value of Poisson's ratio for skin [11,43,44], ligament and tendon [45][46][47] beyond the limit of incompressible material (−1 to 0.5).…”

supporting

confidence: 61%

Effect of collagen fibre orientation on the Poisson's ratio and stress relaxation of skin: an ex vivo and in vivo study

et al. 2022

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During surgical treatment skin undergoes extensive deformation, hence it must be able to withstand large mechanical stresses without damage. Therefore, understanding the mechanical properties of skin becomes important. A detailed investigation on the relationship between the three-dimensional deformation response of skin and its microstructure is conducted in the current study. This study also discloses the underlying science of skin viscoelasticity. Deformation response of skin is captured using digital image correlation, whereas micro-CT, scanning electron microscopy and atomic force microscopy are used for microstructure analysis. Skin shows a large lateral contraction and expansion (auxeticity) when stretched parallel and perpendicular to the skin tension lines, respectively. Large lateral contraction is a result of fluid exudation from the tissue, while large rotation of the stiff collagen fibres in the loading direction explains the skin auxeticity. During stress relaxation, lateral contraction and fluid effluxion from skin reveal that tissue volume loss is the intrinsic science of skin viscoelasticity. Furthermore, the results obtained from in vivo study on human skin show the relevance of the ex vivo study to physiological conditions and stretching of the skin during its treatments.

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supporting

confidence: 61%

Effect of collagen fibre orientation on the Poisson's ratio and stress relaxation of skin: an ex vivo and in vivo study

et al. 2022

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“…However, dynamic testing poses additional challenges of measurements (MacManus et al 2017a). Compared with the indirect measurement of slice thickness (Wang et al 2020), a direct measurement using an independent laser sensor could be more accurate. However, one of the limitations is dehydration of the sample for viscoelastic measurement.…”

Section: Discussionmentioning

confidence: 99%

Measurement of viscoelastic properties of injured mouse brain after controlled cortical impact

et al. 2020

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Mechanical properties of brain tissue can provide vital information for understanding the mechanism of traumatic brain injury (TBI). As mouse models were commonly adopted for TBI studies, a method to produce injury to the brain and characterize the injured tissue is desired. In this paper, a complete workflow of TBI induction, sample preparation, and biomechanical characterization is presented for measurement of the injured brain tissue. A controlled cortical impact device was used to induce injury to the brain. By setting the angle, speed, and position of the impact, the level of brain injuries could be controlled. Viscoelastic properties of both injured and non-injured brain tissues were measured using a ramp-hold indentation test. Regions of interests (ROIs) were tested and compared to contralateral corresponding counterparts. Methods introduced in this paper could be easily extended to produce and test a variety of other injured soft biological tissues.

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“…Since the contact mechanics of soft materials is less well understood (Butt, Pham, & Kappl, 2017), current studies seek to provide further insights into force mechanisms and contact behavior (Ciavarella, Joe, Papangelo, & Barber, 2019; Lai & Hu, 2021; Shoaib & Espinosa‐Marzal, 2018; Wang et al., 2020). To the best of our knowledge, contact mechanics models have not yet been applied to indentation studies of brain tissue.…”

Section: Methodsmentioning

confidence: 99%

Tissue‐Scale Biomechanical Testing of Brain Tissue for the Calibration of Nonlinear Material Models

et al. 2022

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Brain tissue is one of the most complex and softest tissues in the human body. Due to its ultrasoft and biphasic nature, it is difficult to control the deformation state during biomechanical testing and to quantify the highly nonlinear, time‐dependent tissue response. In numerous experimental studies that have investigated the mechanical properties of brain tissue over the last decades, stiffness values have varied significantly. One reason for the observed discrepancies is the lack of standardized testing protocols and corresponding data analyses. The tissue properties have been tested on different length and time scales depending on the testing technique, and the corresponding data have been analyzed based on simplifying assumptions. In this review, we highlight the advantage of using nonlinear continuum mechanics based modeling and finite element simulations to carefully design experimental setups and protocols as well as to comprehensively analyze the corresponding experimental data. We review testing techniques and protocols that have been used to calibrate material model parameters and discuss artifacts that might falsify the measured properties. The aim of this work is to provide standardized procedures to reliably quantify the mechanical properties of brain tissue and to more accurately calibrate appropriate constitutive models for computational simulations of brain development, injury and disease. Computational models can not only be used to predictively understand brain tissue behavior, but can also serve as valuable tools to assist diagnosis and treatment of diseases or to plan neurosurgical procedures. © 2022 The Authors. Current Protocols published by Wiley Periodicals LLC. This article was corrected on 16 April 2022. See the end of the full text for details.

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Characterizing poroelasticity of biological tissues by spherical indentation: An improved theory for large relaxation

Cited by 28 publications

References 76 publications

Effect of collagen fibre orientation on the Poisson's ratio and stress relaxation of skin: an ex vivo and in vivo study

Effect of collagen fibre orientation on the Poisson's ratio and stress relaxation of skin: an ex vivo and in vivo study

Measurement of viscoelastic properties of injured mouse brain after controlled cortical impact

Tissue‐Scale Biomechanical Testing of Brain Tissue for the Calibration of Nonlinear Material Models

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