Characterizing Myocardial Deformation in Patients With Left Ventricular Hypertrophy of Different Etiologies Using the Strain Distribution Obtained by Magnetic Resonance Imaging

Abstract

This work was partially funded by the Industrial and Technological Development Centre (CDTI) under the CENIT Programme (CDTEAM project) and the European Community's Seventh Framework Programme (FP7/2007-2013) [grant number 224495] (euHeart project). G. Piella was supported by the Ramón y Cajal Programme from the Spanish Ministry of Science and Innovation. larger strain heterogeneity (compared to controls, athletes and HT-LVH), and they presented non-deforming regions.

Characterization of normal regional myocardial function by MRI cardiac tagging

“…The circumferential strain increases from the base towards the apex (E CC base < E CC mid and E CC base < E CC apex ), and this result is in agreement with several previous studies . Regarding variations between regions, E CC was higher at the anterior and lateral wall than inferiorly or the septal wall.…”

“…However, the midwall strain parameter derived from radial displacements (E RR ) had the greatest variability among hearts due to the lowest spatial density of tag data in the radial direction on MR‐tagged images . The range of E RR was 7.6%–22.3% (mean 11.6%), similar to the radial strains reported by Young et al (range of E RR : 2.0%–22.0%; mean 15.0%), Lawton et al (range of E RR : 9.0%–16.0%; mean 11.8%) and Piella et al (range of E RR : 14.0%–28.0%), while Kuijer et al , Moore et al , and Bogaert and Rademakers reported a higher range: 26.0%–42.0% (mean 31.0%), 30.0%–52.0% (mean 38.0%), and 32.8%–46.6% (mean 38.5%), respectively. Radial strain was lowest medially, which agrees with previous studies , and was highest at the inferior and the lateral wall than anteriorly or the septal wall.…”

“…Principal and normal strains are used to describe myocardial regional function . Nevertheless, the second one is more widely used.…”

Unravelling the grey zone: cardiac MRI volume to wall mass ratio to differentiate hypertrophic cardiomyopathy and the athlete's heart

“…These include late gadolinium enhancement (LGE), strain on tagged MRI30 and the morphology of papillary muscles and mitral valve 4. In our study, the use of a gadolinium-contrast medium in healthy athletes was considered unethical.…”

An Automated Tensorial Classification Procedure for Left Ventricular Hypertrophic Cardiomyopathy

“…In order to provide greater understanding about these factors, comparative regional studies have been carried out in [10] for athletes, controls and HCM patients; the authors reveal a significant reduction in the diagonal components of the strain in HCM patients and athletes, but this reduction was not associated to any particular segment and it was even present in non-fibrotic regions. In [11] a local analysis is performed fusing the information of MR-Cine and Late Enhancement MR to provide more insight into the mechanical properties of the fibrotic tissue in HCM.…”