Characterizing Microscopical Invasion Patterns in Canine Mast Cell Tumours and Soft Tissue Sarcomas

Russell, Duncan S.; Townsend, Katy L.; Gorman, Elena; Bracha, Shay; Curran, Kaitlin M.; Milovancev, Milan

doi:10.1016/j.jcpa.2017.08.002

Cited by 11 publications

(11 citation statements)

References 37 publications

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“…Histologic margins are commonly described as being incomplete or complete, with incomplete histologic margins being defined as neoplastic cells extending to the edge of the surgical resection margins or 'tumour on ink'. [1][2][3][4][5][6] However, in some studies, an incomplete histologic excision has been arbitrarily defined as a HTFM ≤1 mm, [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] ≤2 mm 23 or ≤5 mm. 24 The assessment of histologic margins is further complicated by the common use of 'close' or 'narrow' histologic margins in veterinary oncology.…”

Section: Histologic Margins: Complete Incomplete and Closementioning

confidence: 99%

“…The completeness of histologic excision is used to determine the risk of local tumour recurrence and the requirement for further local treatment, such as re‐excision or radiation therapy. However, incomplete histologic excision does not necessarily result in local tumour recurrence (see below for specific examples), and other factors can have an impact on local tumour recurrence, such as tumour size, tumour type, tumour subtype, mitotic rate, histologic grade, degree of invasiveness, proliferation markers and molecular factors (eg, mutations in KIT exon 11 in canine cutaneous MCTs) …”

Section: Clinical Relevance Of Histologic Margins: Assessing the Riskmentioning

confidence: 99%

“…As described above, the completeness of histologic excision is not the only determinant of the risk of local tumour recurrence. Other histologic criteria could be investigated to determine their effect on local tumour control, such as lymphatic invasion, vascular invasion, perineural invasion, tissue invasion, histologic grade, proliferation indices and molecular markers . Based on the findings of these studies, the R classification scheme could be modified to develop a more refined treatment algorithm for specific tumour types.…”

Section: Future Considerations For the Proposed Residual Tumour Classmentioning

confidence: 99%

See 2 more Smart Citations

Histologic margins and the residual tumour classification scheme: Is it time to use a validated scheme in human oncology to standardise margin assessment in veterinary oncology?

Liptak¹

2019

Vet Comparative Oncology

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There is no consensus on the definition of a complete histologic excision in veterinary oncology; many definitions have been used in various studies, but these have been arbitrarily selected with no apparent justification. The residual tumour classification scheme, where a complete histologic excision is defined as a histologic tumour‐free margin >0 mm, has been used for >40 years in human oncology by all of the major clinical staging organizations and is considered highly prognostic for the vast majority of malignant tumours in people. Because of the widespread use of the residual tumour classification scheme both clinically and in research studies, this standardized approach permits better communication between clinicians, an evidence‐based decision‐making process for adjuvant treatment options following surgical resection, minimizes exposing patients to unnecessary adjuvant treatments and a better ability to compare local tumour control for specific tumours between different studies. The adoption of the residual tumour classification scheme in veterinary oncology would likely achieve similar outcomes and minimize the prevalent confusion within the veterinary community, amongst both general practitioners and specialists, regarding the definition of what constitutes a complete histologic excision.

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Section: Histologic Margins: Complete Incomplete and Closementioning

confidence: 99%

Section: Clinical Relevance Of Histologic Margins: Assessing the Riskmentioning

confidence: 99%

Section: Future Considerations For the Proposed Residual Tumour Classmentioning

confidence: 99%

See 1 more Smart Citation

Histologic margins and the residual tumour classification scheme: Is it time to use a validated scheme in human oncology to standardise margin assessment in veterinary oncology?

Liptak¹

2019

Vet Comparative Oncology

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“…The higher frequency of neoplastic infiltration of the skin overlying sSTSs graded higher than I may be correlated to their more aggressive behavior and their possible tendency to more extensively infiltrate the surrounding tissues 5,9 . It has recently been reported that, as compared to mast cell tumors, both grade I and grade II STSs were characterized by more compact growth, with less extensive circumferential and deep invasion, potentially allowing for less aggressive surgery 10 …”

Section: Discussionmentioning

confidence: 99%

“…The skin overlying the tumor is included in the en bloc excision; however, no information regarding its neoplastic infiltration is available in the veterinary literature. Moreover, only a few studies have investigated the histologic pattern of growth of sSTS in the surrounding tissues in dogs 5,9,10 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of the neoplastic infiltration of the skin overlying canine subcutaneous soft tissue sarcomas: An explorative study

Magno

Morello

Iussich

et al. 2021

Vet Comparative Oncology

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Studies regarding the neoplastic infiltration of the skin overlying canine subcutaneous soft tissue sarcoma (sSTS) are lacking. In case of the absence of tumor infiltration, there would be the possibility of leaving this unaffected skin in place, thus simplifying surgery. The aim of the study was to investigate whether the skin overlying sSTSs is infiltrated by neoplastic cells. Dogs with sSTSs treated surgically were prospectively enrolled. After excision, the skin was dissected from the tumor along the natural surgical plane of cleavage and histologically evaluated. Twenty‐nine dogs with an sSTS were included (22 grade I, 6 grade II, and 1 grade III). The sSTS‐overlying skin was not tumor‐infiltrated in 14/29 cases (48.3%). A higher frequency of infiltration was observed in higher grade sSTSs (grades II and III, 100%; P = .006); nevertheless, 8/22 grade I sSTSs (36%) also showed cutaneous infiltration. This infiltration involved the dermis of the skin directly in contact with the tumor (multifocal in 11 and diffuse in four cases). Although the cutaneous tumor infiltration is less frequent in grade I sSTSs and a wide excision may still be the safest treatment for any sSTS for a greater possibility of local control, this study opens the possibility to a less aggressive cutaneous excision, but still with a local curative intent, as only the skin directly in contact with the sSTS has been proven to be tumor‐infiltrated. Additional studies are warranted to confirm that excision of only this skin may guarantee a complete local control, especially in lower‐grade sSTSs.

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The Pathology of Neoplasia

Kamstock¹,

Russell²,

Powers³

2020

Withrow and MacEwen's Small Animal Clinical Oncology

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Characterizing Microscopical Invasion Patterns in Canine Mast Cell Tumours and Soft Tissue Sarcomas

Cited by 11 publications

References 37 publications

Histologic margins and the residual tumour classification scheme: Is it time to use a validated scheme in human oncology to standardise margin assessment in veterinary oncology?

Histologic margins and the residual tumour classification scheme: Is it time to use a validated scheme in human oncology to standardise margin assessment in veterinary oncology?

Evaluation of the neoplastic infiltration of the skin overlying canine subcutaneous soft tissue sarcomas: An explorative study

The Pathology of Neoplasia

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