Characterizing lung resident mesenchymal stem cells in idiopathic pulmonary fibrosis

Martin, A; Jahn, Andreas; Río, Carlos; Iglesias, Amanda; Mercader, Josep M.; Montes, Ana; Crespı́, Catalina; Pons, Jaume Mascaró; Velasco, Julio; Villena, Cristina; Carvajal, Angel F.; Gigirey, Orlando; Elowson, Linda; Westergren‐Thorsson, Gunilla; Molina-Molina, María; Llinàs, Ernest Sala

doi:10.1183/13993003.congress-2020.457

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“…They found that in patients with IPF or ILD ABCG2 pos cell numbers were decreased relative to control, possibly because most of them differentiated into myofibroblasts contributing to the lung remodeling during IPF ( Marriott et al, 2014 ). In another functional study, Martin et al compared LR-MSCs from donor and IPF patients and found that IPF derived LR-MSCs presented a decreased genetic profile in the oxidative phosphorylation pathway and had reduced potential to induce the repair of a lung epithelial wound in an in vitro indirect co-culture system ( Martin et al, 2020 ). Thus, abnormalities in endogenous LR-MSCs may contribute to aberrant alveolar repair responses in IPF.…”

Section: The Role Of Lung Resident Mesenchymal Stromal/stem Cells In Lung Homeostasis Injury and Repairmentioning

confidence: 99%

Dissecting the Role of Mesenchymal Stem Cells in Idiopathic Pulmonary Fibrosis: Cause or Solution

et al. 2021

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Idiopathic pulmonary fibrosis (IPF) is one of the most aggressive forms of idiopathic interstitial pneumonias, characterized by chronic and progressive fibrosis subverting the lung’s architecture, pulmonary functional decline, progressive respiratory failure, and high mortality (median survival 3 years after diagnosis). Among the mechanisms associated with disease onset and progression, it has been hypothesized that IPF lungs might be affected either by a regenerative deficit of the alveolar epithelium or by a dysregulation of repair mechanisms in response to alveolar and vascular damage. This latter might be related to the progressive dysfunction and exhaustion of the resident stem cells together with a process of cellular and tissue senescence. The role of endogenous mesenchymal stromal/stem cells (MSCs) resident in the lung in the homeostasis of these mechanisms is still a matter of debate. Although endogenous MSCs may play a critical role in lung repair, they are also involved in cellular senescence and tissue ageing processes with loss of lung regenerative potential. In addition, MSCs have immunomodulatory properties and can secrete anti-fibrotic factors. Thus, MSCs obtained from other sources administered systemically or directly into the lung have been investigated for lung epithelial repair and have been explored as a potential therapy for the treatment of lung diseases including IPF. Given these multiple potential roles of MSCs, this review aims both at elucidating the role of resident lung MSCs in IPF pathogenesis and the role of administered MSCs from other sources for potential IPF therapies.

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Section: The Role Of Lung Resident Mesenchymal Stromal/stem Cells In Lung Homeostasis Injury and Repairmentioning

confidence: 99%

Dissecting the Role of Mesenchymal Stem Cells in Idiopathic Pulmonary Fibrosis: Cause or Solution

et al. 2021

View full text Add to dashboard Cite

show abstract

Characterizing lung resident mesenchymal stem cells in idiopathic pulmonary fibrosis

Cited by 1 publication

References 0 publications

Dissecting the Role of Mesenchymal Stem Cells in Idiopathic Pulmonary Fibrosis: Cause or Solution

Dissecting the Role of Mesenchymal Stem Cells in Idiopathic Pulmonary Fibrosis: Cause or Solution

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