Characterizing longitudinal changes in rabbit brains infected with Angiostrongylus Cantonensis based on diffusion anisotropy

Tsai, Hao-Hung; Shyu, Ling-Yuh; Lim, Seong Yong; Tyan, Yeu–Sheng; Weng, Jun‐Cheng

doi:10.1016/j.actatropica.2016.01.020

Cited by 1 publication

(2 citation statements)

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“…This study not only analyzed the clinical manifestations, but also analyzed and summarized the imaging characteristics and differential diagnosis of the disease, corresponding to its pathological basis. When the larvae of A. cantonensis reach the CNS, they reside in areas such as the pia mater, cerebrum, and cerebellum, where they release metabolites that lead to inflammation of the surrounding tissues; infiltration by large numbers of lymphocytes, eosinophils, and macrophages; local vasodilation; and gradual formation of eosinophilic granulomas around the parasites (Tsai, Shyu, Lim, Tyan, & Weng, ; Wang, Jung, Chen, Wang, & Li, ). Tsai et al () infected rabbit brains with A. cantonensis and reported widened intercellular spaces and infiltration of erythrocytes and inflammatory cells, indicating the occurrence of vasculitis after infection.…”

Section: Discussionmentioning

confidence: 99%

“…. cantonensis reach the CNS, they reside in areas such as the pia mater, cerebrum, and cerebellum, where they release metabolites that lead to inflammation of the surrounding tissues; infiltration by large numbers of lymphocytes, eosinophils, and macrophages; local vasodilation; and gradual formation of eosinophilic granulomas around the parasites(Tsai, Shyu, Lim, Tyan, & Weng, 2016; Wang, Jung, Chen, Wang, & Li, 2015). Tsai et al (2016) infected rabbit brains F I G U R E 3 (a-d) Male, 46 years old.…”

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Magnetic resonance imaging findings and clinical manifestations in cerebral angiostrongyliasis from Dali, China

Yang

Yang²,

Chen³

et al. 2019

Brain and Behavior

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Purpose To analyze magnetic resonance imaging (MRI) findings and clinical diagnosis and treatment data relating to Angiostrongylus cantonensis infection to gain insight into the disease. Materials and Methods We retrospectively analyzed the epidemiology, clinical manifestations, diagnosis and treatment data, imaging manifestations, and outcomes of 27 patients who were clinically diagnosed with angiostrongyliasis and who underwent contrast‐enhanced brain MRI. Results Patients with A. cantonensis infection had a history of eating raw mollusks in the endemic area, and they mainly presented with dizziness and headache of varying degrees and vomiting ( n = 7). Laboratory examinations revealed increased peripheral blood and cerebrospinal fluid (CSF) eosinophils, as well as increased CSF protein levels. Brain MRI findings mainly included eosinophilic meningitis, whereas linear or nodular enhancement of the pia mater was observed in enhanced T1‐weighted and fluid‐attenuated inversion recovery images, accompanied by encephalitis or vasculitis. Meningitis manifested as multiple, thickened flow voids around the meninges, and contrast‐enhanced scans showed substantial enhancement in intracranial dilated and hyperplastic blood vessels. Conclusion The possibility of A. cantonensis infection should be considered in the effective use of albendazole or mebendazole as a treatment. Combining clinical history with laboratory examination is helpful in diagnosing A. cantonensis infection. A final definite diagnosis can be confirmed by detecting larvae in the CSF. The administration of corticosteroids during pathogen therapy can substantially reduce the therapeutic response.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%